this is wild - i was aware of Mary-Claire King's absurdly important discoveries on BRCA / inherited breast cancer but I had no idea that her first PhD paper (King & Wilson 1975, Science, not bad lol) is the "99% of protein coding shared btwn chimps and humans" result www.science.org/doi/abs/10.1...

Science Friday@scifri.bsky.social · 12mo ago

Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.

RosettaFold 3 is here! 🧬🚀 AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release! Congratulations @simonmathis.bsky.social and team!!! ❤️ bioRxiv preprint: www.biorxiv.org/content/10.1...

Boltz-1 update Boltz-1x introduces inference-time steering for much higher physical quality, CUDA kernels for faster, more memory-efficient inference and training. www.biorxiv.org/content/10.1...

Boltz-1: Democratizing Biomolecular Interaction Modeling

Understanding biomolecular interactions is fundamental to advancing fields like drug discovery and protein design. In this paper, we introduce Boltz-1, an open-source deep learning model incorporating...

biorxiv.org

BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design https://www.biorxiv.org/content/10.1101/2025.04.06.647261v1

...where a powerful toy slingshot can be used to mount the LoRa node in a tree for better line-of-sight communications with other devices. www.instructables.com/Meshtastic-S...

🚀 Thrilled to share our latest work from Zhang Lab, now published in Science (www.science.org/doi/10.1126/...) We introduce TIGR-Tas, a PAM-free, compact, modular RNA-guided DNA-targeting system in prokaryotes & their viruses. More details coming soon 👀 #TIGR #RNA #GeneEditing #CRISPR

Sequencing by Expansion (SBX) -- a novel, high-throughput single-molecule sequencing technology https://www.biorxiv.org/content/10.1101/2025.02.19.639056v1

Wait-a-minute 3 in 1 COVID, Flu A, and B tests are already available from Amazon. Is the RSV one coming? I missed the memo. a.co/d/4s5izkO

This is pretty cool: Scientists have isolated the gene that may be responsible for the reason grapefruit interferes with some meds. It's not the solution, but it's a start. I love grapefruit but it messes with one of my meds, so this makes me happy. www.scientificamerican.com/article/why-...

Why Grapefruit Interferes with Medication, and What to Do about It

Could gene editing produce a tasty citrus fruit that doesn’t interfere with prescription drugs?

scientificamerican.com

Arzeda has been awarded DARPA funding to advance AI-driven protein design—even with limited data! We're pushing the boundaries to create next-gen proteins for national security, sustainability, and beyond. #AI #ProteinDesign www.prnewswire.com/news-release...

Arzeda Awarded DARPA Funding to Advance AI-Driven Protein Design for National Security

/PRNewswire/ -- Arzeda, the industry-leading Protein Design Company™, today announced it has been selected for an award from the Defense Advanced Research...

prnewswire.com

Speculative writeup and the webinar Feb 20 web.cvent.com/event/e77566...

Catharine.Aquino@catharineaquino.bsky.social · 2y ago

There is so much speculation about this. According to Aseq, it is expected to be a big box generating 15B reads in 4hrs, most likely at Q20 with 500 bp reads. What is worth noting is that Roche is not a startup, they have the resources to see this through. aseq.substack.com/p/roche-nano...

From the dependably insightful @aukehoekstra.bsky.social .

Auke Hoekstra@aukehoekstra.bsky.social · 2y ago

This can't be repeated often enough: batteries are getting cheaper incredibly fast. This not only means that our cars can drive on electricity. But also that solar and wind become "firm" sources of power, and we can use our electricity grid much better. www.iea.org/reports/batt...

Our inability to reliably study algorithmic info ecosystems, and why it matters for #scicomm. Pre-publication version of our forthcoming PNAS piece led by Nicky Krause and Isabelle Freiling : osf.io/preprints/so... (a 🧵)

You guys remember TweetDeck? Bluesky has it, and it's free. Check out 🔗 deck.blue by @gildaswise.com for a multi-column interface. 2/10

NEW paper 🚨! We engineered TNT sensors in soil bacteria for long-term detection of explosive in natural soil, enabling geospatial detection of contaminated soil. This work (led by Erin Essington) included new sensors, circuits, modeling, & a 28-day testing workflow. 1/ www.nature.com/articles/s41...

An autonomous microbial sensor enables long-term detection of TNT explosive in natural soil - Nature Communications

Engineered microbes can detect harmful chemicals, but may not work well in complex environments. Here, the authors built microbial sensors for detection of TNT explosive and tested their response over...

nature.com

This is a really cool paper. They developed a reasonably robust circuit to generate patterns.

Tom Ellis@proftomellis.bsky.social · 2y ago

SynBio Turing patterns in E.coli. I've seen this amazing project progress over the last few years at Imperial and excited that it's now published. Well done to all involved! www.cell.com/cell-systems...

🧬🖥🧪 Here are some healthy reminders on just how much Illumina still dominates the #genomics space... 😐

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

The infographic & some extra info here if anyone is interested www.compoundchem.com/2014/08/21/c...

Compound Interest: Why Doesn’t Honey Spoil? – The Chemistry of Honey

Honey is something of an oddity, in that, unlike most foods, it doesn’t spoil over time. In fact, the oldest known sample of honey, found in an Ancient Egyptian tomb and dated to approximatel…

compoundchem.com

Rumors are that they will release model and weights next week.

Arzeda has now produced and sold 10 tons of ProSweet RebM™ stevia, a natural, zero-calorie sweetener, marking a major step forward in sustainable production for the food industry. #biosky www.businesswire.com/news/home/20...

Arzeda, Co-founded by Nobel Laureate David Baker, Drives Industry Innovation with Intelligent Protein Design Technology™ and Delivers Performance Products to Fortune 500 Companies

Arzeda, the leading industrial protein design company co-founded in 2009 by Nobel laureate and University of Washington School of Medicine biochemistr

businesswire.com

Washington's Dream, plants! youtube.com/shorts/Mz-Er...

Greenhouse Nursery Trade Gallons Part 2

YouTube video by Smith's Gardentown

youtube.com

Bluesky has grown to 13M users in a year and a half — thank you all for choosing us! We’ve raised a $15M Series A to support our growth and continue to build an open social network that is designed around you, the user.

Bluesky@bsky.app · 2y ago

Bluesky now has 13M+ users, the @atproto.com developer ecosystem continues to grow, and we’ve shipped features like DMs and video! We’re excited to announce that we’ve raised a $15M Series A to continue growing the community, investing in Trust and Safety, and supporting the dev ecosystem.

New preprint by @jgi.doe.gov's Leo Baumgart, Ronan O'Malley and many others Mapping binding sites of 360 TFs across 10 🌿Brassicaceae genomes. 1.1 million TF-target gene assignments in Arabidopsis thaliana alone!

Marc Somssich@somssich.bsky.social · 2y ago

📜 An atlas of conserved transcription factor binding sites reveals the cell type- resolved gene regulatory landscape of flowering plants 🧑‍🔬 Leo A. Baumgart, Abraham Morales-Cruz, Sharon I. Greenblum, Ronan C O'Malley,et al. 📔 bioRxiv 🔗 www.biorxiv.org/content/10.1... #️⃣ #PlantScience #PlantEvoDevo

Design of a biomolecular adaptive controller to restore sustained periodic behavior https://www.biorxiv.org/content/10.1101/2024.10.11.617962v1

Design of a biomolecular adaptive controller to restore sustained periodic behavior https://www.biorxiv.org/content/10.1101/2024.10.11.617962v1

Periodic behavior is a widespread biological phenomenon occurring across various spatiotemporal scal

biorxiv.org

Part 1 had me in stitches youtu.be/JYqfVE-fykk?... Part 2 great work youtu.be/VJ62EfUKI3w?...

Washington's Dream 2 - SNL

YouTube video by Saturday Night Live

youtu.be

Marburg in Rwanda, 20 cases reported taarifa.rw/rwandas-heal...

Rwanda’s Health Ministry Provides Update on Marburg Virus Outbreak: Six Dead, 20 Infected - Taarifa Rwanda

On Sunday afternoon, the Ministry of Health in Rwanda held a press conference to update the public on the country’s first-ever outbreak of the Marburg virus. Health Minister Dr. Sabin Nsanzimana confi...

taarifa.rw

Here are some useful links to my work. Please bookmark for easy access! 💚 Open Laboratory Notebook: tinyurl.com/ATGCFFE Open Data Repository: tinyurl.com/ATGCSWEET Web Store for Plasmids and Goodies: atinygreencell.com Binomica Labs GitHub: github.com/Binomica-Labs

Bluesky now has over 10 million users, and I was #1,292,419!