We have a new paper outlining the latest challenges and future directions for Mendelian randomization. We used AI to review 10,126 abstracts from studies using Mendelian randomization. www.nature.com/articles/s41...

Challenges and future directions for Mendelian randomization - Nature Genetics

Mendelian randomization is widely used but relies on specific assumptions that are rarely systematically assessed. This Perspective argues that researchers should rigorously test these assumptions thr...

nature.com

JAMA Cardiology marks its 10th anniversary with gratitude to founding Editor in Chief Robert O. Bonow, MD, MS. In his farewell Editorial, Bonow reflects on building a top-cited cardiovascular journal: “It’s a very rare, once‑in‑a‑lifetime opportunity.” ja.ma/3NM60Ow

New event at #AHA2025! GPM Symposium Model Systems: Preclinical to Phase I Bridge Nov 7 12:30-5:15 Learn state-of-the-art systems to bridge therapies from the Preclinical to Phase I trials Speakers: Kricket Seidman, Joe Wu, Kiran Musunuru, Vicki Parikh, Eric Adler, and more!

Amid the hype of using polygenic scores for embryo selection, some thoughts on their implementation potential in real-world settings (and problems) 👇

Massive multi-ancestry GWAS resource for 1,167 clinical traits & diseases in 6 global biobanks (n=1,789,365) 👉29,139 locus-trait pairs 👉2,624 non-overlapping loci across the genome 👉associated with 6 traits each (median) 👉colocalization across traits for 72% of loci [1/3]

Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations! www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social

Thanks to @mglevin.bsky.social for sharing this new heart failure PRS from @naturegenet.bsky.social, 🔗: www.pgscatalog.org/score/PGS005.... This and more in the latest release, submit your scores at www.pgscatalog.org/submit!

Michael Levin@mglevin.bsky.social · last yr.

Excited to see this published: rdcu.be/egHer Common- and rare-variant genetic analyses of heart failure in >2 million individuals 🔘 Dozens of new common variant loci 🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes 🔘 A PRS modifies penetrance of TTNtv

105 new loci at #genome-wide significance linked to 5 distinct traits/diseases with shared #GeneticSusceptibility to #HeartFailure doi.org/10.1038/s415... @DavidSMLee @bvoight28.bsky.social @MarylynRitchie @damrauer #TranslationalScience

Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum - Nature Genetics

Common-variant and rare-variant association analyses combining datasets from multiple populations yield insights into the genetic architecture of all-cause heart failure across the allele-frequency sp...

doi.org

Angiographic Burden of Coronary Atherosclerosis Contributes To Adverse ASCVD Outcomes Independent Of Traditional Risk Factors https://www.medrxiv.org/content/10.1101/2025.04.06.25325252v1

Excited to see this published: rdcu.be/egHer Common- and rare-variant genetic analyses of heart failure in >2 million individuals 🔘 Dozens of new common variant loci 🔘 Confirmation of rare damaging variation in "definitive" cardiomyopathy genes 🔘 A PRS modifies penetrance of TTNtv

Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum

Nature Genetics - Common-variant and rare-variant association analyses combining datasets from multiple populations yield insights into the genetic architecture of all-cause heart failure across...

rdcu.be

Interested in calculating polygenic scores in the All Of Us workbench? Like those from @pgscatalog.bsky.social? Take a look at our new documentation for how to run pgsc_calc in the cloud environment: pgsc-calc.readthedocs.io/en/latest/ho.... Very much work-in-progress, optimisations incoming!

Effect of Disclosing a Polygenic Risk Score for Coronary Heart Disease on Adverse Cardiovascular Events www.ahajournals.org/doi/10.1161/...

CXCL12 drives natural variation in coronary artery anatomy across diverse populations @cellcellpress.bsky.social @tassimes.bsky.social www.cell.com/cell/fulltex...

Q: How many genes should be tested for patients with hypertrophic cardiomyopathy? A: 29 Excited to share our latest: Re-Appraisal of HCM genes by our ClinGen Hereditary CVD Gene Curation Expert Panel out today in @jaccjournals.bsky.social www.sciencedirect.com/science/arti...

Genes Associated With Hypertrophic Cardiomyopathy: A Reappraisal by the ClinGen Hereditary Cardiovascular Disease Gene Curation Expert Panel

Hypertrophic cardiomyopathy (HCM) is an inherited cardiac condition affecting ∼1 in 500 and exhibits marked genetic heterogeneity. Previously publishe…

sciencedirect.com

Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates. https://ja.ma/3W8RykL

🚀 Here are key takeaways from today's JAMA and JAMA Cardiology presentations at #AHA24: Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates. ���️ ja.ma/4fKewpK

🚨 Our work exploring polygenic risk scores for Coronary Heart Disease is now out in @JAMA_current and presented at #AHA24 by all-star #SarnoffCardio fellow Sarah Abramowitz!

JAMA@jama.com · 2y ago

Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates. #AHA24 https://ja.ma/3YTigyp

Excited for these trainee presentations from the lab at @ahascience.bsky.social #AHA24, spanning cardiovascular genomics and precision medicine. Come check out these talks, moderated posters, and posters to learn more about our work!