Fantastic work!

Tobias Warnecke@tobiaswarnecke.bsky.social · 5d ago

Who needs chromatin anyway...? NOT THIS GUY! www.biorxiv.org/content/10.6... 1/n

New preprint from the lab! One reason why I chose work on trypanosomes is to address this question "How do they determine kinetochore position without a centromeric histone H3 variant, CENP-A/CenH3?" After working on this question for 16 years, we finally got a clue

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 2w ago

The centromere localization domain of kinetoplastid kinetochore protein KKT2 recognizes the free N-terminus of histone H3 https://www.biorxiv.org/content/10.64898/2026.08.13.744621v1

Now accepted in Journal of Cell Science @jcellsci.bsky.social doi.org/10.1242/jcs....

Identification of feeding apparatus components in a heterotrophic marine flagellate

Diplonemids are highly abundant heterotrophic single-celled flagellates that are widespread in the world's ocean. They have a highly complex microtubule-based feeding apparatus (cytostome-cytopharynx ...

doi.org

Bungo Akiyoshi@bungoakiyoshi.bsky.social · 5mo ago

New preprint! We identified many components that localize to the structure involved in "eating" in a marine organism. #ProtistOnSky #diplonemid www.biorxiv.org/content/10.6...

Now published in JBac. Absolutely great publishing experience!!! Thank you to editors and reviewers.https://journals.asm.org/doi/10.1128/jb.00286-26 Another great one from @tommclean.bsky.social @johninnescentre.bsky.social @hbio-isp.bsky.social

TrbA binds and locks a sliding clamp KorB to repress transcription on multi-drug resistance plasmids | Journal of Bacteriology

Precise regulation of gene expression ensures gene products are produced at the right time and in the right amounts. Recent works uncovered a new mechanism of bacterial gene regulation based on a clamp sliding and locking in a multi-drug resistance plasmid, RK2. KorB functions as a CTP-dependent DNA-sliding clamp capable of traveling over a long genomic distance. Sliding KorB is captured and locked in place by a partner protein, KorA, forming a stable complex at target promoters to repress transcription. Here, we show that another RK2 regulator, TrbA, also uses this clamp sliding-locking mechanism, and identify an aromatic interface enabling TrbA-KorB-mediated transcriptional repression. Our findings show how a single sliding clamp integrates multiple partners to build a complex transcriptional regulatory network.

journals.asm.org

Tung Le@tunglejic.bsky.social · 3mo ago

Here, @tommclean.bsky.social shows that another RK2 regulator, TrbA, likely also use this “clamp sliding-locking” mechanism to regulate gene expression. Interesting how a single sliding clamp might integrate multiple partners to potentially build a complex regulatory network... shorturl.at/YQJOI

The Sasaki lab at the National Institute of Genetics in Japan are seeking for highly motivated PhD students to work on extrachromosomal circular DNA, gene amplification, genome stability, and cancer genome dynamics, starting in October 2027. Please see below and apply by August 31.

Hot, acidic and an endlessly fascinating archaeal model organism! Check out our review on Sulfolobus acidocaldarius🥳

Marleen van Wolferen @marleenvw.bsky.social · 3w ago

With the 50th anniversary of #Archaea research coming up, read our latest review on one of its defining (and my favorite) model organisms: Sulfolobus acidocaldarius. #ArchaeaSky @archaellum.bsky.social, @sshamphavi.bsky.social, @michaelspaedt.bsky.social journals.asm.org/doi/10.1128/...

Our latest publication is on bioRχiv! — a study of the meiotic double-strand break machinery, focused on C. elegans but using the extensive genomic resources available for the whole genus to learn more about how SPO-11 and its cofactors work together to break DNA www.biorxiv.org/content/10.6...

Multifaceted and evolutionarily dynamic interactions between Caenorhabditis elegans SPO-11 and its cofactors ensure proper formation of meiotic DNA double-strand breaks

DNA double-strand breaks (DSBs) generated during meiotic prophase by the topoisomerase-like protein SPO11 are essential to create crossovers between homologous chromosomes. Since crossovers are requir...

biorxiv.org

Bacteriocins in archaea and archaeocins in bacteria. @romainstrock.bsky.social surveys the the exchange of molecular weaponry between archaea and bacteria. www.biorxiv.org/content/10.6...

Bacteriocins in archaea and archaeocins in bacteria

Archaea and bacteria routinely live side by side in microbial communities and must interact at least on occasion. Whether such cross-Domain interactions are dominated by mutual disregard, co-operation...

biorxiv.org

Archaeaophiles! Last chance to sign up as a virtual attendee for MBoA2026. It’s cheap and you will have access to all the talks include our archaea@50 celebration with a special guest: meetings.embo.org/event/26-arc...

Excited to be part of this fantastic project!

Svetlana Dodonova@dodonova-sveta.bsky.social · 2mo ago

Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...

Archaea are the hornets of the microbial world. Discuss. www.biorxiv.org/content/10.6... TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.

now published!!! @johninnescentre.bsky.social @leahmcphillips.bsky.social academic.oup.com/nar/article/...

Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems

Abstract. Low-copy-number plasmids often rely on dedicated maintenance mechanisms, such as partitioning systems, to ensure stable inheritance across genera

academic.oup.com

New preprint! Cell division has to happen at the right place but how Archaea pick that place is unknown. We now identified a three-protein system, Dip, that positions the divisome at midcell in H. volcanii and is broadly conserved across Archaea. A thread 🧵 www.biorxiv.org/content/10.6...

The Bisson Lab at IU (bissonlab.com) is hiring makers/builders/engineers across all career stages to join our team in one of the most exciting and crazy projects I've set to work on. Candidates can email us: saltylab@iu.edu More info in the thread [1/3]

how does loop extrusion and chromatid cohesion interact in interphase? Find out in our latest collaboration with Gerlich lab | | | vvv

Gerlich Lab@gerlichlab.bsky.social · 4mo ago

New preprint out!🧬 How do cells keep replicated sister chromatids linked for DNA repair while folding 3D loops for gene expression? Extrusion folds DNA but separates sisters, while cohesion connects them, risking mutual interference. How do they coexist?🧵👇 🔗 doi.org/10.64898/2026.05.02.722390 1/6

New preprint alert! Together with Tetsuya Yamamoto at Hokkaido University, we propose a “polymer micelle” model of transcriptional bursting. www.biorxiv.org/content/10.6...

Our new preprint! 🧬✨ www.biorxiv.org/cgi/content/... @ynagata.bsky.social et al. combined single-nucleosome imaging with Fucci probes to follow local chromatin behavior during interphase. Local nucleosome motion stays nearly constant from G1 to G2, except in early G1. Thanks to all coauthors!

🚨Pls repost!🚨 I'm looking for a postdoc who will lead the research investigating the mechanisms of epigenetic reprogramming using mouse embryos. Background in chromatin biology and genomics is desirable. The application deadline is 28 May. Please apply here!! www.dundee.ac.uk/work-for-us/...

Postdoctoral Research Assistant

Closing date: Thursday 28 May 2026, 23:59

dundee.ac.uk

Paper published! PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes -PDS5 facilitate NIPBL dissociation from cohesin, stopping loop extrusion -Extrusion governs chrm compartmentalization by competing w/polymer relaxation authors.elsevier.com/sd/article/S...

PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes

PDS5 proteins regulate genome organization by halting cohesin-mediated loop extrusion. Wutz et al. show that PDS5 promotes NIPBL dissociation from cohesin, enabling CTCF boundary formation and proper ...

cell.com

Ed Banigan@irate-physicist.bsky.social · 12mo ago

Excited to share our preprint w/Gordana Wutz, Iain Davidson, Leonid Mirny, Jan-Michael Peters www.biorxiv.org/content/10.1... Evidence that PDS5A/B limits NIPBL-cohesin life w/effects on CTCF boundaries & chrm compartments, +mechanisms of compartment-extrusion interplay & cohesin regulation by PDS5

【NEWS】EMBO–MBSJ Laboratory Leadership Forum 2026 in Tokyo Institute of Science Tokyo Yushima Campus, M&D Tower Saturday, June 27, 2026 To foster diverse perspectives in the discussions, we also encourage applications from women researchers. sites.google.com/view/embo-mb...

Our latest paper is online. www.nature.com/articles/s41... We expanded the speed-optimized DNA-PAINT sequences from 6 to 12 — enabling faster, higher-resolution multiplexed super-resolution imaging of up to 10 cellular targets. Here's the story. 1/n

High-speed multiplexed DNA-PAINT imaging of nuclear organization using an expanded sequence repertoire - Nature Communications

Banerjee, Anand, and colleagues present an expanded speed-optimized DNA-PAINT sequence repertoire. This repertoire allows for improved multiplexing capability in super-resolution imaging, maintaining ...

nature.com

Now published in @cytoskeljournal.bsky.social !🎉 Diurnal Regulation of Flagellar Length and Swimming Speed in the Red-Tide Raphidophyte Chattonella marina 🔗 doi.org/10.1002/cm.7... © 2026 Wiley #protistsonsky

Diurnal Regulation of Flagellar Length and Swimming Speed in the Red‐Tide Raphidophyte Chattonella marina

The raphidophyte Chattonella marina is a harmful algal bloom (HAB) species known for its distinct diurnal vertical migration (DVM), a behavior important for its survival and bloom formation. However,...

doi.org

🚨Hear, hear, fellow microbial cell biologists!🚨 🦠 Bacterial and Archaeal Cell Biology will be represented again at this year’s CELL BIO (ASCB-EMBO) meeting! The deadline to be considered for a talk in our Minisymposium is June 9. Help us spread the word! www.ascb.org/cellbio2026/

Cell Bio 2023-An ASCB|EMBO Meeting

Network, learn, and collaborate with top cell biologists from around the globe.

ascb.org

Hearts have topological defects. By treating the mouse myocardium as a 3D nematic, we found disclination lines threading through it. In situs inversus hearts, twist must match structural chirality for contraction to work, as found by quantifying the nematic chirality. biorxiv.org/content/10.6...

Finally published. Many thanks to a wonderful collaborative team and scientific platforms!!! And thanks to editors and reviewers for enthusiasm and a great review. www.nature.com/articles/s41...

A bacterial CARD–NLR-like immune system controls the release of gene transfer agents - Nature Microbiology

An immunity-like system functions as a lysis control hub to promote gene transfer agent particle release from host bacterial cells, suggesting that bacterial immune systems may be co-opted to promote ...

nature.com

Tung Le@tunglejic.bsky.social · last yr.

1/ Excited to share our latest work on gene transfer agents (GTAs) in Caulobacter crescentus, led by Emma Banks in collaboration with Pavol Bardy and Mai Nguyen from York!!! See a brief thread below. shorturl.at/o6S1w

Very pleased to say that the paper version of our study examining the role of de novo DNMTs in cancer-associated hypomethylation is now out in @plos.org Genetics 🎉: doi.org/10.1371/jour... You can read more on the previous thread but here is a summary of the main updates! #epigenetics 🧵 1/9

Duncan Sproul@sproullab.bsky.social · 2y ago

New pre-print alert 🚨 Interested in what @ikafetzo.bsky.social learned about DNA hypomethylation in cancer from investigating surprising gains DNA methylation in DNMT1 KO cells? Read all about it here: www.biorxiv.org/content/10.1... For a quick summary see this 🧵 1/8 #epigenetics

Excited to share our structural insights into how microtubules differentially guide phosphorylation of kinetochore-microtubule regulators, Ndc80 and MCAK, for chromosome segregation. Heroic efforts by Yiming Niu with a fun collaboration with Jennifer DeLuca lab! www.science.org/doi/10.1126/...

Microtubules guide Aurora B substrate geometries for accurate chromosome segregation

Cryo-EM reveals how kinetochore-microtubule attachment is regulated by Aurora B substrate accessibility on microtubules.

science.org

The Rockefeller University @rockefeller.edu · 5mo ago

Microtubules have been viewed as passive structural supports, but a study from @hirofunabiki.bsky.social in @science.org Advances redefines microtubules as active regulators, helping to prevent abnormalities in the number of chromosomes, a hallmark of cancer. 🔗: https://bit.ly/4v8miCC

My first, first author paper is now on #ScienceAdvances ! Linker histone H1 is a liquid-like "glue" condensing chromatin, which revises textbooks! 📖✨ science.org/doi/10.1126/sc… Huge thanks to @kazu-maeshima.bsky.social , for supervision. Amazing collab with @rcollepardo.bsky.social ’s group! 1/

🧬 Last call to join us in Cambridge for #EMBOMBoA26 (July 6th-10th)! We are just one week away from the registration and abstract submission deadline for the EMBO Workshop on the Molecular Biology of Archaea!

【拡散希望】私も運営に携わらせてもらっているEMBO–MBSJ Laboratory Leadership Forumが6月27日に東京で開催されます！ラボ運営に必要なスキルについて学べる貴重な機会だと思いますので、みなさん是非ご参加ください！

The Molecular Biology Society of Japan (MBSJ)@mbsj-official.bsky.social · 5mo ago

【NEWS】EMBO–MBSJ Laboratory Leadership Forum 2026 in Tokyo Institute of Science Tokyo Yushima Campus, M&D Tower (formerly Tokyo Medical and Dental University) Saturday, June 27, 2026 sites.google.com/view/embo-mb...