JCI - Myotonic Muscle Activity Drives a Persistent Pain State Responsive to NaV1.8-directed Analgesics www.jci.org/articles/vie...

We wrote a tutorial guide on voltage imaging, now out in Neuron: authors.elsevier.com/a/1nlgh3BtfH... Indicators, microscopes, and software have all advanced to the point that it's not so hard -- you can now directly watch the electrical activity of neurons in live animals or in culture.

Finally made it to NeuroBio, looking forward to meeting more UK molecular and cellular neuroscientists tomorrow! #NeuroBioUK26

Well deserved! When I was searching for an example of how a discovery about the brain unlocked an entirely new class of therapies (while writing Elusive Cures), orexin is what I pointed to. It doesn't always happen this way. When it does **it's epic** and we should celebrate.

Albert and Mary Lasker Foundation@laskerfdn.bsky.social · 11h ago

The 2026 Basic Medical Research #LaskerAward honors Emmanuel Mignot and Masashi Yanagisawa for discovering orexin, a brain peptide that maintains wakefulness, and for showing that its absence causes narcolepsy. Learn more: https://ow.ly/I1V450ZLA1p #Lasker2026 Stanford Medicine 🧪

Here is the details from UKRI (I've not yet read) www.ukri.org/news/ukri-mo...

Kirsty Grainger @kirstygrainger.bsky.social · 14h ago

Chris McDonald at UUK conference just announced UKRI will - increase grant decisions by internal UKRI expert teams (less to peer review) - fewer, larger awards - increase distributed peer review - more face to face decision making for high priority risky grants (to reduce AI peer review)

It was great working with students Kun and Ryan and @hannahlong.bsky.social, combing the literature to try and find examples of bona fide disease-causing variants in non-coding elements - promoters, enhancers and silencers. www.nature.com/articles/s41...

Mechanisms underlying disease-causing variants in promoters and enhancers - Nature Genetics

This Review discusses how rare-disease-causing variants in the noncoding genome impact gene regulation, why these examples are so few and how new approaches could accelerate discovery of noncoding var...

nature.com

Join us on Wed 7 Oct for a packed programme of talks, panels and interactive workshops at #RAREsummit26 - exploring policy, care, health data, partnerships and innovation. 📍 Cambridge or online 🎟️ Programme & tickets: camraredisease.org/raresummit26... #RareDisease #RareConditions

Using iPSC-derived human #neurons gene-edited to express pathogenic #KIF1A variants, @aikenlab.bsky.social, @erikaholzbaur.bsky.social et al. demonstrate that distinct alterations in KIF1A motor function disrupt synaptic development through divergent cellular mechanisms rupress.org/jcb/article/...

New book chapter from @jcornwallscoones.bsky.social & me On GRNs as dynamical systems. Wiring diagrams alone can't predict network behaviour. Understanding developmental patterning needs quantitative, experimentally defined rules for how CREs integrate TF inputs books.google.co.uk/books?hl=en&...

Open Questions in Developmental Biology

This book explores the enduring and emerging questions in developmental biology, offering a comprehensive overview that bridges traditional concepts with the innovative inquiries shaping future resear...

books.google.co.uk

Laminin β4 is required for the development of human peripheral sensory neurons Read this Research Article from our special issue #DevSIextracellular by Kenyi Saito-Diaz @kenyisama.bsky.social, Nadja Zeltner and colleagues. journals.biologists.com/dev/article/...

Researchers in the Gracheva @yaleneuro.bsky.social and Bagriantsev labs found that hibernating squirrel mechanosensory neurons—which convert touch sensation into electrical signals—are adapted to survive in low temperatures and retain their signaling capabilities.

How Hibernating Squirrels Retain Sense of Touch in the Cold

Mechanosensory neurons in ground squirrels retain their signaling abilities despite prolonged exposure to cold temperatures.

medicine.yale.edu

If you haven’t read the dedication of Gloria Steinem’s autobiography My Life on the Road, it is really worth taking a second today.

We remember biochemist and chemistry laureate Ada Yonath who passed away this week at the age of 87. In 2009, Yonath shared the Nobel Prize in Chemistry with Venkatraman Ramakrishnan and Thomas Steitz for studies of the structure and function of the ribosome. Learn more: https://bit.ly/4kJscDU

PRISM: A Plasmid-based Reporter for Intracellular Spectral Microscopy by Jonathon Nixon-Abell and team: www.biorxiv.org/content/10.6...

Should be the biggest story today by some distance. Truly mad that it isn’t. www.businessgreen.com/news/4535094...

UN: World now all but certain to 'overshoot' critical 1.5C global warming threshold

UNEP sets out 'best-case' scenario of 1.8C for global average temperature rise, but maintains world can still limit, adapt to, and eventually reduce warming to or below 1.5C threshold in future

businessgreen.com

Nobel Prize winner Ada Yonath sadly passed away today. She was a legend for her pioneering work on the structure of ribosomes.

There are multiple pain-relation NIH positions are open! Reach out for more info.

Elizabeth Sypek@elizabethis.bsky.social · 2w ago

Honest, i would still recommend this job. I love what i do, and we need good people to keep it going.

Great tribute to the discovery by Barbara Pearce of clathrin, the first protein found to act in membrane traffic, along with her mentoring and support of the pioneers (many of whom were other women) who revealed the workings of this key player in cellular function.

Traffic@traffic-journal.bsky.social · 2w ago

Happy 50th anniversary, Clathrin! onlinelibrary.wiley.com/doi/full/10.... @effc.bsky.social

Happy #FluorescenceFriday! 🔥 Neural crest cells are bringing the heat again! These migrating cells weave through the developing quail embryo, leaving beautiful patterns in their wake. 😍🧪🔬 📷 @siewzhuan.bsky.social 🔬

Special bonus quote of the day The way I see it, if you want the rainbow, you gotta put up with the rain. Dolly Parton

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

And for the sake of balance…

Daniel Craig on SNL: 'The Weekend'

ALT: Daniel Craig on SNL: 'The Weekend'

static.klipy.com

Nivedita Sarveswaran@neuroniv.bsky.social · 3w ago

Measure your days not by the tasks you complete, but by the memes your feed bestow

Hello, human geneticist here. There is no scientific basis for attempts to define people in terms of “good” or “bad” genes - these are discredited views in service of racist ideologies. For consensus & concerns of experts in our field, see e.g. this 2020 statement from @geneticssociety.bsky.social:

Measure your days not by the tasks you complete, but by the memes your feed bestow

What a week, huh? all Wednesdays@whataweekhuh.bsky.social · 3w ago

My quote of the day I think the environment should be put in the category of our national security. Defense of our resources is just as important as defense abroad. Otherwise what is there to defend. Robert Redford

I am proud of this paper. Since it came out in 2022 it has received 0 citations (yes that's a zero). But multiple young scientists have found it useful! (from other labs, so they were not coerced...). Perhaps you will find it useful too? SOME TIPS FOR WRITING SCIENCE doi.org/10.1523/ENEU...

Some Tips for Writing Science

When preparing a scientific paper, we typically write with coauthors who have different backgrounds and styles, and we target readers who have little time and patience. To help both readers and writer...

doi.org

Do you want to be part of our flagship public engagement event, and have the chance to exhibit your research to over 10,000 members of the public? The call for proposals for the #SummerScience Exhibition 2027 is now open. Find out more on our website: royalsociety.org/science-even...

Our work on the role of the proteasome in developmental tempo is out!!!! 🐭⌛️👤⏳ Six years after identifying an association between protein stability and developmental tempo, we now demonstrate a causal link between protein turnover and developmental tempo through proteasomal degradation

Developmental Cell@cp-devcell.bsky.social · 4w ago

Online now: Proteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitors #biology #science

When you’re scrolling around a 96-well plate and spot a resistant colony 🔬

imbecile

Alt: Actor Tom Glyn Carney plays Aegon II Targaryen, with a burnt face and ragged blond hair. He bends down to confront his brother Aemond “I’m aliiive”, who is kneeling and in shock that Aegon isn’t dead.

static.klipy.com

'I understand why the cost and speed of grant making are important but neither are a proxy for quality, and lessons from the 2007 RCUK Shared Service Centre experiment seem long forgotten.' Important read with great grasp of the longer history and thus the wider context. 1/4

Cost and speed are not measures of quality grant making

Kirsty Grainger asks whether UKRI's commitment to faster grant making will improve the quality, fairness and effectiveness of research funding

wonkhe.com