In case you are interested in (re)generation of insulin-producing cells, check out this preprint and our perspective @jiaruimi.bsky.social @zebrafishrock.bsky.social @uu.se

Development@dev-journal.bsky.social · last mo.

In preprints – ‘slow & steady’ versus ‘fast & ready’ (re)generation of insulin-expressing cells in #zebrafish @o-andersson-lab.bsky.social & co discuss a preprint by Gräßlin & co that extends knowledge of cellular conversions in the pancreas, based on single-cell transcriptomics & epigenetics.

🚨We are #hiring! Excited to welcome a talented #postdoc to join the lab. and be part of an interdisciplinary research program #Type1DiabetesGrandChallenge -- harnessing #pancreas #development for #stem cell therapy of #diabetes. 🧫🧪🔬 Join us! Apply before 23 July. ⤵️ my.corehr.com/pls/coreport...

*** GRC Developmental Biology 2027 - Jan 17-22 @ Renaissance Tuscany Il Ciocco Resort *** Join us for a fabulous 2027 Gordon Conference on all things #devbio & the trainee-led GRS! More info on registration, abstract submission, et al., here: www.grc.org/developmenta... #GRCDevBio2027 🧬🐭🐟🪰🌱❤️

The countdown is on for the #EASD2026 abstract submission! Only 3 weeks left to submit your abstract for the 62nd EASD Annual Meeting in Milan. 📅 Deadline: 1 April 2026 | 🕛 18:00 CEST 📢 Submit via MyEASD: www.easd.org/annual-meeti... #diabetes #research #abstractsubmission #annualmeeting

🔬 Advance your diabetes research & save $250! Register for the Keystone Symposium on Islet Biology & Diabetes by Jan. 15 (11:59 PM MST). Hear why it matters from @linnemannlab.bsky.social 🎥 youtu.be/4olDczSNJMo Register: keysym.us/KSDiabetes26 @o-andersson-lab.bsky.social #KSDiabetes26

KSQA: Dr. Amelia K. Linnemann (Islet Biology and Diabetes)

YouTube video by KeystoneSymposia

youtu.be

Two new articles from our lab!! Davis et al identified epithelial transcription factor ELF3 as a key mediator of host-microbiota interaction in zebrafish tinyurl.com/pkavnxdp Morash et al revealed enteroendocrine cell subtypes in zebrafish & catalogued their peptide hormones tinyurl.com/bdzbm2xm

Identification of intestinal enteroendocrine cell subtypes and their associated hormones in zebrafish

Enteroendocrine cells (EECs) in the gut epithelium secrete diverse hormones that regulate digestion, energy use, and behavior. This study identifies EEC subtypes and their hormone profiles in zebrafis...

tinyurl.com

Volumetric near-infrared light-sheet imaging of a calcium indicator (WHaloCaMP) in a zebrafish larval brain. Credit to @helenfarrants.bsky.social, William "Bill" Lemon, & Philipp Keller at @hhmijanelia.bsky.social. #ZebrafishZunday 🧪

Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy link.springer.com/article/10.1... 🔓

Bri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress - Diabetologia

Aims/hypothesis Accumulation of islet amyloid polypeptide (IAPP) and amyloid formation is associated with beta cell dysfunction and cell death in human islets and may also contribute to graft failure ...

link.springer.com

Deadlines are approaching (some next week!) for @keystoneSymposia.bsky.social #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March in Breckenridge! See scholarship, abstract and discount reg dates: keysym.us/KSDiabetes26 #KSDiabetes26

Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery | Keystone Symposia

Join us at the Keystone Symposia on Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery, March 2026, in Breckenridge, with field leaders!

keysym.us

Nov 18 is the deadline for short talk abstracts + scholarship apps for the Keystone Symposium on Islet Biology & Diabetes. Hear more from @linnemannlab.bsky.social: 🎥 youtu.be/4olDczSNJMo. Apply: keysym.us/KSDiabetes26 #KSDiabetes26 #diabetes #drugdiscovery @o-andersson-lab.bsky.social

KSQA: Dr. Amelia K. Linnemann (Islet Biology and Diabetes)

YouTube video by KeystoneSymposia

youtu.be

The deadline for short talks at the Keystone Islet Biology symposium is approaching (Nov 18th) - submit it here: www.keystonesymposia.org/conferences/... For great science and skiing March 16-19th in Breckenridge, Colorado @linnemannlab.bsky.social @keystonesymposia.bsky.social

Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....

Benchmarking porcine pancreatic ductal organoids for drug screening applications | EMBO Molecular Medicine

imageimageState-of-the-art single-cell RNA sequencing and proteomics approaches were employed to benchmark porcine and human pancreatic ductal organoid systems for use as a drug screening and testing ...

embopress.org

Any danish located postdoc who wants to apply to work with us and zebrafish, pls contact me (postdocs from other places can also get in touch, as we have other alternatives) novonordiskfonden.dk/en/grant/pos...

Postdoctoral Fellowships at Uppsala University - 2026 - Novo Nordisk Fonden

novonordiskfonden.dk

Join us for the revival of the Islet Biology and Diabetes Keystone symposia in Breckenridge, Colorado on March 16-19, 2026, for great science and great skiing. You can register now for early bird rates: lnkd.in/dw59T7tc Joint with Gut-Brain Axis. @linnemannlab.bsky.social Erica Nishimura, Barak Blum

Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes - Nature Metabolism

LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β c...

nature.com

Join us as a professor by taking this great opportunity in pharmacology (in any system/area) www.uu.se/en/about-uu/...

Professor of Pharmacology - Uppsala University

Professor of Pharmacology, Department of Medical Cell Biology, Uppsala University

uu.se

🚨 Just out in Nature Communications: Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish We challenge old assumptions on liver regeneration! 🔗 nature.com/articles/s41... 🧵(1/8)

Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish - Nature Communications

During partial liver injury in growing zebrafish, cholangiocytes regenerate hepatocytes through transdifferentiation, revealing a stage-specific regeneration mechanism regulated by mTORC1 signaling.

nature.com

Our paper has been out for a while but was included in today's issue, featuring our cover suggestion made by the brilliant Mattias Karlen www.nature.com/nchembio/vol... @ckarampelias.bsky.social @uu.se

Bring your favourite model system and help advance our understanding of how living organisms interact with and adapt to their environment. Apply here: uu.varbi.com/en/what:job/...

Assistant Professor in Environmental Physiology

Uppsala University’s tenure track system grants assistant professors the possibility to be assessed for promotion to the position as associate professor. The university provides support in various a

uu.varbi.com

We’re excited to share our recently published story “A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing” in @mucosalimmunol.bsky.social Fantastic work led by @ramoralescastro.bsky.social ! www.mucosalimmunology.org/article/S193...

A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing

The intestine is a semipermeable tissue responsible for the absorption of essential nutrients while limiting exposure to harmful environmental factors. To maintain these functions, the intestinal epit...

mucosalimmunology.org

What an elegant study showing that the mode and shape of cell division is defined by interphase morphology! This work suggests how cell fate and morphological asymmetries can be propagated via cell division in tissues. www.science.org/doi/10.1126/... #academiasky

Interphase cell morphology defines the mode, symmetry, and outcome of mitosis

During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

science.org

At the Stainier lab’s 30th year celebration, funtastic colleagues

Great opportunity & startup for someone that wants to start their lab studying inflammation/immune system (perhaps in metabolism, diabetes or the islet...) external/international candidates are wanted: uu.varbi.com/en/what:job/...

Associate Senior Lecturer (SciLifeLab Fellow) in inflammation research

The Science for Life Laboratory (SciLifeLab) is a national center for leading edge technological infrastructures that supports large-scale data and hypothesis-driven research in the field of molecular

uu.varbi.com

Amazing work on a DRiP neoantigen in beta-cells, where a protective SNP creating an IRE1 digestion motif and reducing the level of ER stress, DRiP, and type 1 diabetes... www.cell.com/cell/fulltex...

Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay

Insulin gene variation predisposes individuals to type 1 diabetes (T1D). We report a new mechanism of genetic protection from T1D in which insulin mRNA with a protective SNP is broken down by IRE1α, t...

cell.com

Deadline extended to March 23!!👇

Anna Krook@annakrook.bsky.social · 2y ago

Don’t miss this unique meeting bringing together leading Swedish researchers and practitioners in diabetes to share the latest advancements in diabetes research 👉 lnkd.in/dbbh6vcd Hope to see you in Umeå!

Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1

Benchmarking porcine pancreatic ductal organoids for drug screening applications

Primary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and disease. Yet, donor material availability, and a lack of extensive benchmarking limits the range ...

biorxiv.org

Thank you Bart Roep for visiting, explaining a "not unlikely" beta-cell-centric origin of type 1 diabetes, and giving us a sneak peak of next week's issue of Cell

1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵

Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin

Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…

sciencedirect.com

A new #evolution #EvoDevo #devbio #amphioxus #invertebrate paper this week @ScienceAdvances | Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates www.science.org/doi/full/10....

Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates

Single-cell profiling of the amphioxus digestive tract reveals scattered distribution of three endocrine-like cell clusters.

science.org

Notable inclusions include latests works of the Martik Lab, @sgraingerphd.bsky.social, @singhlab.bsky.social, @ditalialab.bsky.social, @o-andersson-lab.bsky.social, @blmartin.bsky.social, @tillymommersteeg.bsky.social, Megason Lab, Yelon Lab, Maves Lab, @thelovelylab.bsky.social among others!

the Node@the-node.bsky.social · 2y ago

📃January in preprints First preprint list of 2025 is out! Check out the #preprints in #DevBio, #StemCell biology (and related fields) that came out in January. Congrats to everyone involved 🎉 And as usual, let us know if we've missed anything 👀 thenode.biologists.com/january-in-p...