Daniel Lipka
@dblipka.bsky.social
Physician Scientist at DKFZ & NCT Heidelberg studying 🩸🧬 #epigenomics #DNAmethylation #singleCell #precisiononcology #JMML www.translational-cancer-epigenomics.de
Neue Erkenntnisse zu akuten Leukämien: Bestimmte Mutationen liefern Ansatzpunkte für gezieltere Therapien Forschende des NCT Heidelberg und des Deutschen Krebsforschungszentrums (@dkfz.bsky.social) haben erstmals systematisch ermittelt, wie bestimmte Mutationen akute myeloische Leukämien fördern.
‼️ Pre-print alert from the Lipka lab ‼️ Our latest work “Hierarchical classification of hematologic malignancies using epigenetic and genetic information” is now online! www.biorxiv.org/content/10.6... Thanks to all colleagues who contributed to this work! 🙏
Hierarchical classification of hematologic malignancies using epigenetic and genetic information
Molecular testing in hematology requires different assays for disease subgroup identification, risk stratification and selection of appropriate treatment regimens. Yet, molecular tests are not necessa...
biorxiv.org
Hierarchical classification of hematologic malignancies using epigenetic and genetic information https://www.biorxiv.org/content/10.64898/2026.07.02.735835v1
‼️ Pre-print alert from the Lipka lab ‼️ Our latest work “Hierarchical classification of hematologic malignancies using epigenetic and genetic information” is now online! www.biorxiv.org/content/10.6... Thanks to all colleagues who contributed to this work! 🙏
Hierarchical classification of hematologic malignancies using epigenetic and genetic information
Molecular testing in hematology requires different assays for disease subgroup identification, risk stratification and selection of appropriate treatment regimens. Yet, molecular tests are not necessa...
biorxiv.org
😱 Seeing the global temperature change like this is absolutely shocking.... showyourstripes.info/c/globe
Show Your Stripes
Visualising how the climate has changed for every country across the globe
showyourstripes.info
I’m excited to share that my PhD paper is officially out now in @bloodjournals.hematology.org Check out our discovery of how mutant IDH1 but not IDH2 leads to a lineage-specific differentiation block via epigenetic repression of lineage programs! 📄 Paper link below: 👇 doi.org/10.1182/bloo...
Daniel Lipka@dblipka.bsky.social · 2mo ago🧵 NEW PAPER in @bloodjournal.bsky.social! Why do IDH1 mutations almost exclusively drive myeloid #leukemia, while IDH2 mutations occur in both myeloid AND lymphoid cancers? 🤔 #AML #Epigenetics Despite sharing the same biochemical mechanism, they are NOT equivalent. Here's what we found 👇
Data manipulation at a breathtaking scale by commercial providers of crucial research reagents. As if the few remaining lab scientists didn't face enough obstacles already.
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
reeserichardson.blog
🧵 NEW PAPER in @bloodjournal.bsky.social! Why do IDH1 mutations almost exclusively drive myeloid #leukemia, while IDH2 mutations occur in both myeloid AND lymphoid cancers? 🤔 #AML #Epigenetics Despite sharing the same biochemical mechanism, they are NOT equivalent. Here's what we found 👇
Please RT: Opportunity to join us as technician! We are looking for a technician to support us in our projects in MPN and other myeloid malignancies using epigenomics on primary samples and PDX mouse models. Where: @carrerasijc.bsky.social When: Anytime. What: 👉https://sl1nk.com/0ekf3z6
In this Blood Cancer Discovery study, the authors demonstrate that oncogenic PTPN11 mutations enhance cellular plasticity. This leads to partial restoration of fetal molecular programs, creating new therapeutically exploitable vulnerabilities. buff.ly/QiXstYy
Same mutation ≠ same leukemia. Wagenblast et al. show: • fetal HSCs readily transform • postnatal HSCs become resistant • fetal programs create targetable vulnerabilities Ontogeny matters: state-of-origin shapes biology & therapy response. doi.org/10.1158/2159... #pediatric #AML #stemcells
Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia
AbstractAccumulating evidence links pediatric cancers to prenatal transformation events, yet the influence of the developmental stage on oncogenesis remains elusive. We investigated how hematopoietic ...
doi.org
JMML stem cells aren’t epigenetically “stuck” in a fetal state. They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model. doi.org/10.1158/2643... #JMML #epigenetics #hematology #cancer
Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia
AbstractPersistent fetal gene expression in childhood neoplasms is usually explained by a maturation block originating in the prenatal phase. In contrast, reactivation of fetal genes in adult malignan...
doi.org
New Spotlight in @aacrjournals.bsky.social #Oncogene × #Ontogeny × #Plasticity shape leukemia biology & therapy response. Two complementary studies show: mutations alone don’t explain disease behavior—developmental state and cellular plasticity matter. aacrjournals.org/bloodcancerd... 🩸🧬 EpiSci
A Triumvirate of Transformation: Oncogene, Ontogeny, and Plasticity
Summary:. Cancer cells display extensive heterogeneity that influences therapy response and clinical outcome, yet the underlying mechanisms remain incompletely understood. Recent studies reveal that t...
aacrjournals.org
Staying Current in Data Science and Computational Biology: 2026 Edition. Part 3 in a series of posts going back 14 years. doi.org/10.59350/2na...
Staying Current in Data Science and Computational Biology: 2026 Edition
Part 3 in a series of posts going back 14 years
doi.org
You’ll help build interoperable, FAIR tools across @scverse.bsky.social and @bioconductor.bsky.social ecosystems. You will work together with a cross-institute team composed of @lucamarconato.bsky.social, @arturmansl.bsky.social and many contributors from #scverse and #Bioconductor!
Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo
Enhancers control tissue-specific gene expression across metazoans. Although deep learning has enabled enhancer prediction and design in mammalian cell lines and invertebrate systems, it remains uncle...
biorxiv.org
Excited to share new manuscript on histone acylations, exploring how H4K16 acylations regulate inter and intranucleosomal interactions and how they confer resilience to metabolic challenges in vivo. Thanks to all authors +1 author @sandrani.bsky.social Enjoy 👇👇 www.sciencedirect.com/science/arti...
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations
Histone modifications play crucial roles in genome function. However, how chromatin integrates physiological and metabolic responses at the molecular …
sciencedirect.com
Neue Erkenntnisse zu frühkindlicher Leukämie: Leukämiezellen können Programme aus der fetalen Entwicklung erneut aktivieren. Die Ergebnisse eröffnen neue Angriffspunkte für Diagnostik und Therapie. www.nct-heidelberg.de/das-nct/news... @dkfz.bsky.social @mphartmann.bsky.social @dblipka.bsky.social
👉🏼 @milsommick.bsky.social talking about the role of inflammation on HSC aging in the “Game of Clones” Scientific Session at #ASH25. #epigenomics #hematopoiesis #HemeSky @dkfz.bsky.social
Interested in DNA methylation and want to hear what we can learn from it regarding lineage commitment decisions in #hematopoiesis? #ASH25 #epigenomics #HemeSky
Very happy and proud to see this story finally published! 🎉🥳 #epigenetics #hematology #jmml #leukemia
Mark Hartmann@mphartmann.bsky.social · 8mo agoONLINE FIRST ALERT! Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia aacrjournals.org/bloodcancerd... @aacrjournals.bsky.social #childhoodcancer #epigenetics #precisiononcology
The future of hematological genomics is here. The ASH HematOmics Program (ASHOP) developed with St. Jude & the Munich Leukemia Laboratory offers free access to powerful genomic visualization tools for blood disease research. 🔗 https://ow.ly/G7Ol50XukwQ #Genomics #HemeSky #MedSky
The figures from this book are all freely available through @figshare.com, hopefully helpful for presentations and teaching: figshare.com/projects/Epi... Please let me know if you find any inaccuracies and I'll fix them. I've already updated one of the figures. #EpigeneticsBook
figshare.com
John Greally@greally.bsky.social · 10mo agoMy book on Epigenetics: History, Molecules and Diseases www.amazon.com/Epigenetics-... #EpigeneticsBook #Epigenetics
Great to meet friends and colleagues at this year’s EWOG-MDS meeting in Berlin. We had great discussions and developed new project ideas and collaborations with the aim of improving risk stratification and patient care for JMML patients. #jmml #ewogmds #precisionmedicine www.ewogberlin2025.org
On the Verge to Malignancy: Cytopenia and Beyond - Ewog Symposium
On the Verge to Malignancy: Cytopenia and Beyond International Symposium on bone marrow failure, predisposition, MDS and MPD in the Young Dear colleagues and friends, we are pleased to wel...
ewogberlin2025.org
On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...
Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia
Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!
keysym.us
Of interest to the #epigenomics, #dnamethylation, #neurooncology, #oncology and #precisionmedicine communities! 🧬
Michael Scherer@scherermich.bsky.social · 11mo agoDNA-methylation-based deconvolution can be a powerful tool for identifying novel disease subgroups. In our paper in Acta Neuropathologica, we show how this can be leveraged in IDH-mutant gliomas - specifically in oligodendrogliomas. doi.org/10.1007/s004...
DNA-methylation-based deconvolution can be a powerful tool for identifying novel disease subgroups. In our paper in Acta Neuropathologica, we show how this can be leveraged in IDH-mutant gliomas - specifically in oligodendrogliomas. doi.org/10.1007/s004...
DNA methylation analysis reveals an epigenetic signature distinctive of high-grade oligodendroglioma - Acta Neuropathologica
IDH-mutant gliomas represent a subtype of diffuse gliomas that primarily affect patients in early to mid-adolescence. These tumors are classified into three distinct CNS WHO grades of malignancy. Accu...
doi.org
Epigenetics Update - Fluctuating DNA methylation tracks cancer evolution at clinical scale go.nature.com/3Ve4OUy #Epigenetics #Cancer #DNAme #DNAm --- Empower your research with high-res epigenetic insights at epigenometech.com
Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
Still two weeks left to apply to the #postdoc position in my lab via the @dkfz.bsky.social fellowship program. #epigenomics #hematology #leukemia #computationalbiology #precisiononcology
Daniel Lipka@dblipka.bsky.social · 12mo ago+++ Postdoc Opportunity +++ My lab is looking for researchers interested in combining cutting edge #genomics, #epigenetics and #AI for precision oncology in pediatric #leukemia. www.dkfz.de/fileadmin/us... Applications via the #DKFZ postdoc program: www.dkfz.de/en/karriere/...