What if we could design proteins to precisely control cell behavior? I’m thrilled to share our latest work, led by @kinasekid.bsky.social, @sauravk05.bsky.social, Mia Donald-Paladino, and Dongyang Li, developing de novo miniproteins that activate or inhibit kinases. www.biorxiv.org/content/10.6...

De novo design of selective kinase modulators

Protein kinases are critical regulators of cellular signaling, but precise modulation of their activity remains challenging due to their high structural conservation. Here, we present de novo designed...

biorxiv.org

We have two great talks lined up for the final Friday Afternoon Seminars of the season! For everyone @FredHutch.org, join us at 4:00 in Pelton to hear about the latest discoveries from Yulong Su in the Eisenman Lab and Joy Chen in Human Biology’s @behnamnabet.bsky.social Lab.

.@fredhutch.org study dramatically expands therapeutic range of approved kinase drugs #NBTintheNews www.fredhutch.org/en/news/cent...

Fred Hutch study dramatically expands therapeutic range of approved kinase drugs

A recently published study from Fred Hutch Cancer Center dramatically expands the number of FDA-approved cancer drugs targeting kinases from 89 to 235, with relevance across many kinds of cancer.

fredhutch.org

Comprehensive profiling of clinically approved kinase inhibitors reveals mutation-specific inhibitors and opportunities for drug repurposing - @fredhutch.org go.nature.com/4904pMC

Comprehensive profiling of clinically approved kinase inhibitors reveals mutation-specific inhibitors and opportunities for drug repurposing - Nature Biotechnology

A large screen of approved kinase inhibitors expands the druggable kinome.

go.nature.com

📢 Welcome to issue 4 of RSC Chemical Biology! 🦠 This issue features articles on the roles of lipid droplets in metabolic signalling, siRNA chemical modification strategies, TRK fusion-positive cancer targeting PROTACs and more! ➡️ Read it here pubs.rsc.org/en/Jour... #RSCChemBio

Proud to share our latest paper in @rscchembio.rsc.org, where we tackle oncogenic TRK fusions. Together, @sauravk05.bsky.social and Jiewei Jiang develop potent and selective degraders of the TPM3-TRKA fusion, a key cancer driver. pubs.rsc.org/en/content/a...

Development of PROTACs for targeted degradation of oncogenic TRK fusions

Chromosomal translocations leading to the fusion of tropomyosin receptor kinases (TRKs) with diverse partner proteins have been identified as oncogenic drivers in many adult and pediatric cancers. Whi...

pubs.rsc.org

Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?

Nature Metabolism@natmetabolism.nature.com · 4mo ago

When broken strands of DNA get repaired improperly, they can stitch together in new “Frankengene” fusions that can cause cancer. Fred Hutch researchers are working to better understand how a fusion called ZFTA-RELA drives rare brain tumors in children. https://bit.ly/4bc8WgG

Now online! The E3-ome gene-centric compendium reveals the human E3 ligase landscape

The E3-ome gene-centric compendium reveals the human E3 ligase landscape

The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented knowledge, this framework provides a foundation for studying ubiquitin signaling and accelerating discovery.

dlvr.it

Here is our updated database of grants for early careers researchers in all fields. It goes way beyond traditional NIH and NSF funding opportunities. We list 428 types of grants. Download it here: research.jhu.edu/rdt/funding-...

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

Are you an undergrad looking for a summer internship? Application season is underway! Check out these internship opportunities at Fred Hutch. Apply now: linktr.ee/fredhutch #datascience #statistics #labexperience

New findings on kinase phosphorylation of RNA polymerase II from the Ansari Lab! bit.ly/Dabas_Pol2

Kinase atlas uncovers hidden layers of cell signaling regulation

See how St. Jude scientists linked 117 kinases including EGFR tyrosine kinase to RNA polymerase II phosphorylation, revealing new targets for cancer therapy.

bit.ly

So many phenomenal pumpkins at this year’s carving contest! Congratulations to the Berger Lab for most humorous, the Talbot Lab for most horrific, the @melodygcampbell.bsky.social Lab for most artistic and the @harmitmalik.bsky.social Lab for most scientific!

When #science meets #spookyseason! 🧬🎃 We didn’t think it was possible, but our @basicsci.fredhutch.org and Human Biology Divisions raised the bar once again as they turned their creativity loose on some pumpkins during their annual pumpkin carving contest.

Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social! Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process. See here: www.sciencedirect.com/science/arti...

Defined media reveal the essential role of lipid scavenging in supporting cancer cell proliferation

Fetal bovine serum (FBS) is an undefined additive that is ubiquitous to mammalian cell culture media and whose functional contributions to promoting c…

sciencedirect.com

Lucas Sullivan@lucasbsullivan.bsky.social · last yr.

Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside: A broadly applicable serum-free media, Quantitative lipid uptake characterization, Evidence lipid scavenging > synthesis for cancer cell proliferation.

The Weintraub Award is seeking nominations for 2026! The award recognizes the outstanding achievements of grad students in biology and was established to honor the bold, creative, pioneering spirit embodied by Dr. Hal Weintraub. www.fredhutch.org/en/research/...

Harold M. Weintraub Graduate Student Award

Annual award to honor the bold, creative, pioneering spirit embodied by Hal Weintraub. The Harold M. Weintraub Graduate Student Award recognizes outstanding achievements during graduate studies in the...

fredhutch.org

Excited that our study identifying TRIP12 - an essential E3 ligase mutated in a neurodevelopmental disease - as a critical component of the oxidative stress response is now online. Congratulations to Andrew, Devlon and Jenny! @ucberkeleyofficial.bsky.social www.sciencedirect.com/science/arti...

Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12

Centered on the transcription factor NRF2 and its E3 ligase CUL3KEAP1, the oxidative stress response protects cells from damage by reactive oxygen spe…

sciencedirect.com

I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions. Descriptions and links in the following two posts.

Excited to share our latest paper on how macroH2A is targeted by IE1 during HCMV infection- featured as an editors pick in Nature Communications! Fantastic work by Laurel and team!! www.nature.com/articles/s41...

Human cytomegalovirus induces neuronal gene expression through IE1 for viral maturation - Nature Communications

HCMV rearranges the host cell to produce infectious virus but molecular details are still unclear. Here, the authors analyze the transcriptome of infected cells and show that HCMV turns on dormant neu...

nature.com

The first Nabet lab paddle boarding outing was a success! Couldn’t be prouder of this amazing group — grateful to lead such a committed, collaborative, and inspiring team.

We turn complex science into striking visuals, like this cover we illustrated for Dr. @behnamnabet.bsky.social et al. on FAK inhibitors and PROTACs. 🦋 👩‍🔬 Know someone doing great research? Tag them, we’d love to help share their story. #JournalCovers #DrawImpacts #SciArt

🎉 2025 DFCI TPD event registration is open! 📆 Sep 11, 11:30 AM–8 PM ET, Boston 🔑 Keynote: Nathanael Gray 📝 Registration link: forms.gle/NLUSa51Btrtf... #TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI

We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology! careers.dana-farber.org/job/11813/as...

Faculty/Health Educator Job: Assistant/Associate Professor, Chemical Biology at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA

Assistant/Associate Professor, Chemical Biology job

careers.dana-farber.org

Postdoc positions available! Please re-post! Are you interested in how viruses manipulate chromatin? Are you excited to discover unknown facets of molecular biology? If so, we’d love to hear from you! Come check us out at: avgoustilab.org

🚨 New preprint! Excited to share our latest work, led by @sauravk05.bsky.social (Nabet lab) and Jiewei Jiang (Ferguson‬ lab), on targeting oncogenic TRK fusions. We report potent and selective degraders of TPM3-TRKA, a driver of adult and pediatric cancers. www.biorxiv.org/content/10.1...

Development of PROTACs for targeted degradation of oncogenic TRK fusions

Chromosomal translocations leading to the fusion of tropomyosin receptor kinases (TRK) with diverse partner proteins have been identified as oncogenic drivers in many adult and pediatric cancers. Whil...

biorxiv.org

Sharing the next installment of our fun collaboration with @michaelnadbio.bsky.social at the interface of #ubiquitin and #ADP-ribosylation! Building upon our identification of cellular MARUbylation, we now identify reader/writer E3 ligases that extend K11 polyUb! 🧵 www.biorxiv.org/content/10.1...

A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation

Ubiquitin (Ub) cooperation with other post-translational modifications provides a tiered opportunity for protein regulation. Small modifications to Ub such as phosphorylation, acetylation, or ADP-ribo...

biorxiv.org

Two great talks lined up for the final Friday Afternoon Seminars of the season! For everyone @FredHutch.bsky.social, join us at 4pm in Pelton to hear about the latest discoveries from Rina Hirano in the Tsukiyama Lab and @christinakuismi.bsky.social in Human Biology’s @behnamnabet.bsky.social Lab.

Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus! www.nature.com/articles/s41...

Excited to share the work of postdoc Rachael Bakker in collaboration with @lapointelab.bsky.social! We show that RNA base editors can be repurposed for deep mutational scanning of RNA-RBP interactions at scale both in vitro and in vivo. www.biorxiv.org/content/10.1...

Deaminase-based RNA recording enables high throughput mutational profiling of protein-RNA interactions

Protein-RNA interactions govern nearly every aspect of RNA metabolism and are frequently dysregulated in disease. While individual protein residues and RNA nucleotides critical for these interactions ...

biorxiv.org