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Pegah Poursharifi

@pegpoursharifi.bsky.social

Assistant Professor, Dept. of Biochemistry and Molecular Biology ‪@dalhousie.bsky.social‬ Obesity, adipose tissue, immunometabolism, inflammation https://sites.google.com/view/poursharifi-lab/

6 Posts139 Follower225 Folgt
Daniel Drucker@danieljdrucker.bsky.social · last yr.

Here the Prentki lab proposes that inhibition of monoacylglycerol (MAG) hydrolase α/β-hydrolase domain-containing 6 (ABHD6) in WAT is a therapeutic strategy for improving the health of adipose tissue #obesity www.sciencedirect.com/science/arti...

Suppression of adipocyte ABHD6 favors anti-inflammatory and adipogenic programs to preserve adipose tissue fitness in obesity

Some individuals exhibit metabolically healthy obesity, characterized by the expansion of white adipose tissue (WAT) without associated complications.…

sciencedirect.com

Pegah Poursharifi@pegpoursharifi.bsky.social · last yr.

Excited to share our timely and comprehensive review published in Physiological Reviews, bringing together insights from multiple leading labs in metabolism: Marc Prentki and Murthy Madiraju, Shingo Kajimura, @denispblondin.bsky.social, and Christopher Nolan. journals.physiology.org/doi/abs/10.1...

Glycerolipid Cycling in Thermogenesis, Energy Homeostasis and Signaling | Physiological Reviews | American Physiological Society

Mammals maintain body heat by adaptive energy expenditure through different organ specific mechanisms. The glycerolipid/free fatty acid cycle (glycerolipid cycle), encompassing triglyceride lipolysis ...

journals.physiology.org

TanentzapfLab@tanentzapflab.bsky.social · 2y ago

I've been doing this for 30 years & I still can't believe that when people ask me what I do for a living I get to tell them "I'm a scientist". It feels like a kid's fantasy career that they dress up as for Halloween, like "astronaut" or "pirate". I feel very lucky I get to do this day in & day out.

Lawrence Kazak@kazaklab.bsky.social · 2y ago

Today in @naturecomms.bsky.social we show the #FutileCreatineCycle plays a key role in #thermogenesis, independent of UCP1. We also challenge the belief that brown adipocytes lack enough ATP synthase for thermogenesis. Congrats to Jakub Bunk! @mcgillgci.bsky.social Full paper: rdcu.be/egoV7

The Futile Creatine Cycle powers UCP1-independent thermogenesis in classical BAT

Nature Communications - Thermogenesis by brown adipose tissue has long been thought to be solely controlled by uncoupling protein 1 (UCP1). Here, the authors show that energy expenditure in brown...

rdcu.be

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Hooman Hefzi@hefzi-lab.bsky.social · 2y ago

After ~8 years, happy to share work done w/ @natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social! www.nature.com/articles/s42... #science #biotech #cancermetabolism Thread below:

Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells - Nature Metabolism

Hefzi et al. engineer cells to nearly eliminate lactate production and increase mitochondrial use of pyruvate by deleting both lactate dehydrogenases and pyruvate dehydrogenase kinases with the goal o...

nature.com

Nature Cell Biology@natcellbio.nature.com · 2y ago

💫NEW: Li & co report a central role for #AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy stress during #tumor growth. 👉🏿https://rdcu.be/d8apH www.nature.com/articles/s41...

AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress - Nature Cell Biology

Zhai, Yang et al. report a central role for AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy s...

nature.com