Paul Ettel
@pettel.bsky.social
Immunologist - neutrophils, macrophages, immunometabolism PhD student with Thomas Weichhart @ Medical University of Vienna | MD by training
🫀 Researchers at #MedUniVienna have identified the enzyme MMP12 as a new target for combating heart scarring in #CardiacSarcoidosis. The findings could pave the way for new treatments and improve the management of this often-underdiagnosed condition. Find out more! ⬇️ 📰 @atsblueeditor.bsky.social
Cardiac sarcoidosis: MedUni Vienna identifies enzyme as a target for combating scarring of the heart
More about the therapeutic strategy!
meduniwien.ac.at
we are delighted to announce that our study focusing on Macrophage Arginine Metabolism in Neuroinflammation has been published today in #NatureImmunology. www.nature.com/articles/s41... its time to celebrate 🍷🍻🥂
Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation - Nature Immunology
Kerndl and colleagues identify that arginase 1-expressing monocyte-derived cells mediate arginine catabolism and detrimental effects during experimental autoimmune encephalitis-triggered neuroinflamma...
nature.com
New study from @ivanzheng.bsky.social and colleagues in the Dang lab @ragoninstitute.bsky.social reveals a spatial TH2-STAT6 immune checkpoint in pulmonary #granulomas that suppresses extracellular clearance of #Cryptococcus, promoting persistent infection. rupress.org/jem/article/...
Today, we see the fruit of 5+ years of teamwork. We have built a map of the neutrophil compartment (mostly in mice - but also humans). It provides a biological structure that focuses on a single immune cell lineage to discover the many ways in which neutrophils "interpret" physiology.
Daniela Cerezo-Wallis@dcerezowallis.bsky.social · 8mo agoI’m thrilled to introduce you to the NeuMap! our latest work in@nature.com. A global, comprehensive, single-cell transcriptional atlas of neutrophils across 47 biological conditions in human and mice. A real tour de force www.nature.com/articles/s41...
just new at biorxiv... IRF4 and multi-nucleated giant cells www.biorxiv.org/cgi/content/...
IRF4 is a master regulator of multinucleated giant cell formation
Multinucleated giant cells (MGCs) are a hallmark pathological feature of a wide range of diseases, yet the mechanisms underlying their formation and function remain poorly understood. Although it is r...
biorxiv.org
Not turbo cancer but turbo cancer-immunotherapy! Combining mRNA COVID vaccines with standard-of-care immune therapy overwhelms tumor defenses to improved survival in animal models and large cohorts of people with cancer @nature.com www.nature.com/articles/d41... www.nature.com/articles/d41...
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) www.nature.com/articles/s41...
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
nature.com
#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections
Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived oxidi...
dlvr.it
Paul Ettel, MD-PhD student in the lab has been awarded a prestigious Early Career Fellowship Grant from the Foundation for Sarcoidosis Research (FSR). FSR will support Paul’s research on the role of neutrophils and arginine metabolism in granuloma formation in sarcoidosis. Congratulations!
Very happy to finally share the news that I am among this year's Early Career Fellowship Grant recipients by the Foundation of Sarcoidosis Research. www.globenewswire.com/news-release...
The Foundation for Sarcoidosis Research Awards $450,000 to Support Early-Career Investigators Through the 2025 Fellowship Grant
FSR Early Career Fellowship Grant is designed to support early-career investigators in sarcoidosis....
globenewswire.com
Amitava Sinha via the @preprintclub.bsky.social wrote a nice Journal Club article on a preprint by from the Angelo lab @stanfordmedicine.bsky.social that describes spatial immunometabolic zonation in tuberculosis granulomas: www.nature.com/articles/s41...
Spatial immunometabolic zonation in tuberculosis granulomas - Nature Reviews Immunology
A preprint by McCaffrey and Delmastro et al. delineates distinct immunometabolic zones of tuberculosis granulomas and reports that hypoxia is a key driver of immune subversion.
nature.com
CHOP & @pennmedicine.bsky.social have delivered the first-ever personalized gene editing therapy for a patient with CPS1 deficiency, marking a major milestone in the application of CRISPR-based treatments. Learn more about KJ & the future of personalized medicine: www.chop.edu/news/worlds-....
What a great conference in Crete! Very happy to be among the travel award recipients! See you in two years :))
Aegean Conferences, Inc.@aegeanconf.bsky.social · last yr.Congratulations to all the award recipients. Bravo! 6th Int’l Conference on #ImmunoMetabolism: Molecular and Cellular Immunology of Metabolism. Crete, Greece
🚨 Groundbreaking study reveals how hypoxia shapes immune cell organization in #Tuberculosis granulomas, promoting Mtb persistence. Targeting these metabolic niches could revolutionize TB treatment strategies. A technical tour de force and a major scientific advance! 📖 shorturl.at/WkTgq
With my first Bluesky post, I am very happy to share our latest study led by PhD student Federico De Ponti and postdoc Ania Bujko www.cell.com/immunity/ful...
Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair
scRNA-seq has uncovered ontogenically distinct hepatic macrophage populations, but their functions remain unclear. Here, De Ponti et al. identify recruited LAMs and resident LAM-like KCs in multiple l...
cell.com
www.immunometabolism.at/job-openings... great opportunity to discover new aspects of immunometabolism...
CALL for doctoral and postdoctoral researchers to join the special research program “Immunometabolism”
Three Austrian Universities located in Vienna and Graz combine forces to explore the immunometabolic interaction of macrophages with tissues. We are looking for 6 PhD and 6 postdoctoral researchers jo...
immunometabolism.at
SFB Immunometabolism Austria is looking for PhD students and postdocs. Highly recommended to join the team! Happy to answer any questions. #immunometabolism #phd #postdoc www.immunometabolism.at/job-openings/
CALL for doctoral and postdoctoral researchers to join the special research program “Immunometabolism”
Three Austrian Universities located in Vienna and Graz combine forces to explore the immunometabolic interaction of macrophages with tissues. We are looking for 6 PhD and 6 postdoctoral researchers jo...
immunometabolism.at
1/n Some time ago my colleague, excellent cook, and friend Ivan told me: "Cacio e pepe is the recipe that I screw up more often. Let's make a project studying systematically the physics of that sauce". Prepare to get cheesy, I'm glad to share the Cacio e paper preprint: arxiv.org/abs/2501.00536
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Great paper by @ejvillablanca.bsky.social on LXR gut repair and tumorigenesis www.nature.com/articles/s41...
Liver X receptor unlinks intestinal regeneration and tumorigenesis - Nature
Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.
nature.com
My (little) take on how metabolism regulates neutrophil development and functions and why it should be studied more. Happy if it is helpful to anyone interested! academic.oup.com/jleukbio/art...
Not just sugar: metabolic control of neutrophil development and effector functions
We discuss how neutrophilic metabolism adapts during development, which metabolic pathways fuel their functionality, and how these processes are reconfigur
academic.oup.com
