Stryer

K.W. Colyard@kristianwriting.bsky.social · 5mo ago

So what was everyone's book they read way too young?

'The DHSC is launching a chickenpox vaccination programme which will protect around half a million children each year. And, from January 2026, eligible children will get an MMRV vaccine to protect against measles, mumps, rubella and chickenpox.' Report @mirror.co.uk www.mirror.co.uk/news/health/...

Chris Whitty issues 'severe or life threatening' illness warning

England's Chief Medical Officer is urging people to protect themselves and their children

mirror.co.uk

Me three months ago:

Elizabeth Spiers@espiers.bsky.social · last yr.

My prediction is that in that scenario, he blames the Bureau of Labor Statistics, which puts out employment data. Calls them corrupt, run by Democrats, out to get him. Fires people there, insists their numbers cannot be trusted, White House puts out its own fictitious data to make Trump look good

NEW: The bipartisan Senate Appropriations Committee has rejected Trump’s proposed $18 billion, 40% cut to the National Institutes of Health budget and endorsed a $400 million increase. DO NOT GIVE UP! Our advocacy is working. Keep speaking up and calling your elected officials.

Add a new drug, CETP inhibitor, to the ways beyond lifestyle that we can reduce p-tau 217, the key biomarker for risk of Alzheimer’s disease ir.newamsterdampharma.com/news-release...

#Japan Meteorological Agency has issued a #tsunami warning and advisory for the Pacific coast from #Hokkaido to #Okinawa. The estimate of maximum wave height is now expected to be 3 meter. japannews.yomiuri.co.jp/society/gene...

JMA Issued a Tsunami Warning for the Pacific Coast, with Estimated Maximum Wave Height 3 Meters (UPDATE2 )

<p>The Japan Meteorological Agency issued a tsunami warning and advisory for the Pacific coast from Hokkaido to Okinawa in Wednesday morning. The estimate of maximum wave height is now expected to be ...

japannews.yomiuri.co.jp

Tom Lehrer died today. He was one of the great comedians our culture ever produced. Without Tom, there's no Weird Al, probably no that entire branch of comedy. He went alone and beat the odds. youtu.be/frAEmhqdLFs?...

Tom Lehrer - We Will All Go Together When We Go

YouTube video by The Tom Lehrer Wisdom Channel

youtu.be

Spot-on from @nixonsimon.bsky.social

Simon Nixon@nixonsimon.bsky.social · last yr.

My latest with thoughts on whether Trump is winning his trade wars, what British history can teach America, Europe’s real problem with China, the unstoppable rise of renewables, and the prize for Britain’s worst chancellor...

Yes - I think the one exception is the first time you study a phenotype as black swans may be found. When that not found (unfortunately they are rare). So suggests standard nested - from initial small core multi-modal, then larger and lighter clinical, then online remote sampling population level.

Ewan Birney@ewanbirney.bsky.social · last yr.

<big sigh>. As a rule of thumb, if you gather more multi-modal data, you are going to need more samples (patients) rather than less to be confident of results. Importantly you need some sort of credible belief that for the measurements you propose to do you have some hope of the analysis working

<big sigh>. As a rule of thumb, if you gather more multi-modal data, you are going to need more samples (patients) rather than less to be confident of results. Importantly you need some sort of credible belief that for the measurements you propose to do you have some hope of the analysis working

1. The pediatric death toll from #flu for 2024-25 continues to climb, with #CDC informed of 5 more deaths last week. That brings the season's total so far to 266, which is only 22 fewer than during the 2009 H1N1 pandemic! Of kids eligible for vax & for whom vax status is known, 90% weren't vaxed.

Answer would appear to be yes! "An overwhelming 82% of those who had taken the GCSE CS confirmed that the additional study of Citizenship topics had increased their democratic literacy and confidence about political issues"

Is Citizenship Education the key to unlocking young people’s political engagement? | The Political Studies Association (PSA)

psa.ac.uk

Structural variants are significant contributor to autism. But many SVs & TRs are hard to detect with short reads. Long read sequencing with @pacbio.bsky.social and @nanoporetech.com captures and maps out alot of what short reads miss. So what can LR-WGS tell us about autism? 🧵

medRxivpreprint@medrxivpreprint.bsky.social · last yr.

Long Read Genome Sequencing Elucidates Diverse Functional Consequences of Structural and Repeat Variation in Autism https://www.medrxiv.org/content/10.1101/2025.07.20.25331880v1

Can rightwing press now please agree on the fact that trying to publicise the locations of current Afghan asylum seekers is a stupid idea. www.thetimes.com/article/7a64...

This is quite a big deal and references the Asset Recovery Incentivisation Scheme (ARIS) that POCA-enabled law enforcement orgs receive to boost their funding - after HMT has taken its cut and victims of crime receive compensation. www.telegraph.co.uk/business/202...

Rachel Reeves eyes £5bn Bitcoin sale to help plug black hole

Hoard of seized cryptocurrency could be offloaded to ease pressure on public finances

telegraph.co.uk

We should be having a debate about how British incompetence put the lives of thousands of Afghans at risk. Instead we're having a debate about 'how many criminals they let in'. Tells you everything you need to know about where we're at as a country inews.co.uk/opinion/tori...

Shockingly, the Tories did the right thing on secret Afghan asylum plan

The initial error was egregious, but the response was, at least, morally clear-sighted and practical

inews.co.uk

Comparison of different ways of measuring trait polygenicity, and what properties a "measure of polygenicity" should have. Authors have a really useful section on how to interpret deviations between the measures for a specific trait www.biorxiv.org/content/10.1...

Principled measures and estimates of trait polygenicity

The 'polygenicity' of traits is often invoked and sometimes quantified in quantitative, statistical, and human genetics. What do we mean by the polygenicity of a trait? We propose a principled definit...

biorxiv.org

Bad news for dev bio research ... it needs animal models. A total ban would utterly devastate science. Mathematical modeling is NOT a replication of biology, it's an abstraction. It cannot replace experiments! But, luckily looks like animal research rn can continue as long as modeling is included

boehninglab@boehninglab.com · last yr.

This is extraordinarily dangerous and will slow academic biomedical research and drug development. A total ban is on the horizon. www.drugdiscoverytrends.com/nih-announce...

This will devastate all of my colleagues that do neuroscience in mice. Drugs don't always translate from mouse to human, But 90% of our genes are shared. They allow recordings and manipulations that cannot be done in humans. We will cede discovery to Europe and China with this unnecessary handicap.

NIH announces end to funding for animal-only studies - Drug Discovery and Development

Drug Discovery and Development covers strategies and technologies related to pharmaceutical research and development and drug formulation.

drugdiscoverytrends.com

Someone's been up to some quality work here.

Exciting, but wish the hype was dialled back. "This will enable identification & intervention for individuals at high risk of developing common diseases" probably better as "cheap once in lifetime test will nudge many people over & under certain thresholds for interventions.

Mike Inouye@mikeinouye.bsky.social · last yr.

The UK Govt just released its 10 year plan for the NHS and it is legitimately ambitious and exciting. Genomic population health features heavily... on the cover even! assets.publishing.service.gov.uk/media/686638...

Quite enjoyed the book and the film, but bloody hell....

@chloehadj.bsky.social · last yr.

I spent months on this investigation and gathered docs from the UK courts, Land Registry and a French local authority, to show that Raynor and Moth Winn's story is not as they claim. @tortoisemedia.bsky.social @observeruk.bsky.social observer.co.uk/news/nationa...

An important thing to bear in mind re: midterm elections is that the Medicaid cuts don’t kick in until after the elections. That’s not an accident, and it’s crucial that folks understand what they’re going to lose. Keeping this front of mind for folks will be difficult.

Uh oh

Mark James Adams@markjamesadams.bsky.social · last yr.

This about sums up what it feels like analysing biobank genomic datasets on a cloud platform. youtu.be/pfbzrrcQZjs

Nanopore duplex sequencing reveals patterns of asymmetric states of 5hmC and 5mC in the medaka brain genome. #AsymetricMethylation #5hmC #5mC #MedakaGenome #Nanopore #LongRead #Sequencing @biorxiv-genomic.bsky.social‬ 🧬 🖥️ www.biorxiv.org/content/10.1...

Grant reviewers, before writing "the proposal is not hypothesis driven" (a tired old trope) , ask yourself whether the funding of Copernicus or Newton or Doll was not appropriate because their fundamental science was not hypothesis driven. Observational science is valid and important.

BIG NEWS! We’ve found that ash trees are fighting back against ash dieback disease! 🌳💪 Scientists at Kew & QMUL ‪@qmul.bsky.social have discovered that young ash trees are evolving resistance to this devastating fungus - & fast 🌍 Read the story👉 www.kew.org/read-and-wat... #PlantScience #SciNews

AlphaGenome deepmind.google/discover/blo... 🧬🖥️🧪 API: github.com/google-deepm... Docs: www.alphagenomedocs.com Community: www.alphagenomecommunity.com

Long-acting antivirals for flu seem like the future to me. I hope this pans out in phase three trials! www.biopharmadive.com/news/cidara-...