PLEASE SHARE! New job openings in my lab @zmbp-tuebingen.bsky.social. We have a broad interest into the mechanistic basis of how molecular complexes are rewired during cellular development in plants and during invasion by pathogens. 🌱🍄🔬 See details below 👇 #PlantSciJobs

Riboseek is a fast RNA/DNA search. More sensitive than nhmmer at 250x speed. Structure-aware realignment produces MSAs approaching rMSA quality. Plus 1.7M precomputed RNA MSAs, and an API to search your own 📄 www.biorxiv.org/content/10.6... 💾 github.com/steineggerla... 🌐 search.foldseek.com/riboseek

Super cool initiative by @getgenome.bsky.social ! 🧬 Lots of useful resources, including free plasmid sequencing for researchers in over 100 countries.

Sophien Kamoun@kamounlab.bsky.social · 12mo ago

We just published: Why you should sequence your plasmids (and how to do it for free) Through @GetGenome scientists in 100 countries can access free whole-plasmid sequencing —giving researchers the confidence to move their experiments forward. medium.com/p/why-you-sh...

An unforgettable day in Madrid 🇪🇸 with Roger @rcastellsg.bsky.social who now leads a vibrant lab on protein design @cniostopcancer.bsky.social A shared passion and curiosity for everything science… #Symmetry #CelebratingAlumni

Great catching up in Madrid! 😊 Lots of new ideas and mentoring wisdom. Such a cool time to be in biology! 🔬 #CelebratingMentors

Sophien Kamoun@kamounlab.bsky.social · last wk.

An unforgettable day in Madrid 🇪🇸 with Roger @rcastellsg.bsky.social who now leads a vibrant lab on protein design @cniostopcancer.bsky.social A shared passion and curiosity for everything science… #Symmetry #CelebratingAlumni

We have just launched our newest self-paced tutorial! Protein domains: structure, classification and evolution: www.ebi.ac.uk/training/onl... Learning time: 3 hours Free via EMBL-EBI Training on-demand. @pdbeurope.bsky.social @ebi.embl.org 🧬🖥️

Protein domains: structure, classification, and evolution - An introductory tutorial for protein domains

Protein domains: structure, classification, and evolution - An introductory tutorial for protein domains

ebi.ac.uk

This single author paper has to be seen to be believed.... My 'GIF' does it no justice Chen, M. (2023) ‘Rendering protein structures inside cells at the atomic level with Unreal Engine’, bioRxiv. doi.org/10.1101/2023...

Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam. Try the demo here: store.steampowered.com/app/4045010/... Give Muyuan feedback: steamcommunity.com/app/4045010 #ScienceGaming #StructuralBiology #CryoEM #STEMOutreach

Meowtabolism - Examining Feline Behavior within Unicellular Algae on Steam

Explore the interior of an algal cell on your four paws. Built with experimental data and populated with actual protein structures, Meowtabolism offers a glimpse of the vast world inside the basic fun...

store.steampowered.com

Matthew Collins@matthewcollins.bsky.social · 2y ago

This single author paper has to be seen to be believed.... My 'GIF' does it no justice Chen, M. (2023) ‘Rendering protein structures inside cells at the atomic level with Unreal Engine’, bioRxiv. doi.org/10.1101/2023...

New paper! 🚀 A high-affinity anti- #mNeonGreen #nanobody turns #mNG into a #multifunctional Tag. @nanotag.bsky.social decided to openly share the #nanobody for research use. Not common, but we strongly believe well-defined reagents are key for reproducible science. We hope you find it useful! 💚

Incredibly proud of Messi Haile @mehsehret.bsky.social, a founding member of the Ho Lab, for her beautiful work uncovering the inner workings of a central piece of the malaria parasite invasion machinery: the malarial moving junction, out today in @cellpress.bsky.social! tinyurl.com/4p3md2eb 🦠❄️🔬

“The laser phase plate has the highest continuous light intensity in the solar system, outside of the inner regions of the Sun,” says physicist Holger Müller. Learn more about this landmark achievement in microscopy in @cenmag.bsky.social: cen.acs.org/analytical-c...

15 years, flawless mirrors, and the brightest laser in the world: How physicists brought phase contrast to cryo-EM

Phase contrast enables structures of smaller proteins, could drive in-cell proteomics

cen.acs.org

Cryo-ET gives unparalleled views of cellular structures, but targeted sample preparation by cryo-FIB milling has been a constraint. No longer! A new workflow yields close to 100% targeting success for centrioles & other small structures. Read the preprint ⤵️ www.biorxiv.org/content/10.6...

Looking forward to the exciting science that will come from this collaboration! 😊 So many cool experiments on the way! 🔬 Many thanks to @fundacionoccident.bsky.social for the support through their Visiting Researcher Programme at @cniostopcancer.bsky.social

@cniostopcancer.bsky.social · 2mo ago

➡️Todd Yeates, inventor of protein cages, and Roger Castell-Graells, leader of CNIO's Biomolecular Design and Structural Nanomedicine Group, explain their collaboration thanks to the Fundación Occident Visiting Researcher Programme l1nq.com/t8s5h1i

➡️Todd Yeates, inventor of protein cages, and Roger Castell-Graells, leader of CNIO's Biomolecular Design and Structural Nanomedicine Group, explain their collaboration thanks to the Fundación Occident Visiting Researcher Programme l1nq.com/t8s5h1i

➡️Todd Yeates, creador de las nanopartículas de proteínas, y Roger Castell-Graells, líder del Grupo de Diseño Biomolecular y Nanomedicina Estructural del CNIO, explican su colaboración en Programa de Investigadores Visitantes de Fundación Occident. ➡️ acortar.link/KJIwxU

Las nanopartículas de proteínas se usan para visualizar proteínas muy pequeñas, dianas de fármacos contra el cáncer. Yeates avanzará en su diseño con IA, en colaboración con el grupo de @rcastellsg.bsky.social y el Programa de Biología Estructural del CNIO, dirigido por @oscarllorca.bsky.social

Todd Yeates, de la Universidad de California en Los Angeles #ucla, realizará varias estancias en el CNIO gracias al Programa de Investigadores Visitantes de Fundación Occident. Yeates es el creador de nanopartículas de proteínas que se ensamblan a medida, como en un ‘lego’. 👇🏻 ➡️ acortar.link/KJIwxU

What a great day and place to have a conference! Thank >227 attendees for participating in #SynBYSS Barcelona conference! A snap shot taken when people are still discussing research, not looking at the camera, showing complexity and diversity of engineering biology. @jcvi.org @marcguellc.bsky.social

Happy to share our latest paper on CHIKV assembly combining MD simulations and experiments... amazing collaboration between virologists, physical virologists, and physicists pubs.acs.org/doi/full/10....

Multiple Protein–Protein Interactions Drive the Assembly and Budding of the Chikungunya Virion

The assembly of enveloped viruses is a highly orchestrated process that depends on the coupling of multiple protein–protein interactions within a membrane environment. To gain mechanistic insight into...

pubs.acs.org

Honored to be invited to speak at the MELIS-UPF Biomedical Research Symposium in Barcelona, what a stimulating meeting! It’s been great to share our latest results on the design and structural characterization of new protein cages! @cniostopcancer.bsky.social @upf.edu

11 years since the start of the PhD days. Time flies but friends stay. So good to have JC’s visit in Madrid :) #vlphd #xtalclear @delaconcepcionjc.bsky.social

We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇

@mgflast.bsky.social showing us how to do cellular structural biology on easymode thanks to his collection of pretrained nets 😎 Particularly cool: he demonstrates custom tomo picking workflows e.g. yTuRC at the minus end of MTs, restricting picks to specific cellular compartments Check it out!

Allegretti Lab@matteoall.bsky.social · 2mo ago

We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇

Design and structure of protein cages based on helical fusion and machine learning www.biorxiv.org/content/10.64898/2026.05.27.727936v1 #cryoEM

Excited to share our latest research on leveraging machine learning with helical fusions for the design of novel protein cages! Preprint: “Design and structure of protein cages based on helical fusion and machine learning” Link: www.biorxiv.org/content/10.6...

Diseño Biomolecular y Nanomedicina Estructural Roger Castells @rcastellsg.bsky.social Microscopía Electrónica Jasmina Boskovic Espectroscopía y RMN Ramón Campos-Olivas Producción de Proteínas Jorge M. Torrecuadrada Cristalografía de Proteínas Inés Muñoz ➡️ bit.ly/4tlNsnb

Programa de Biología Estructural

Al integrar los avances en crio-microscopía electrónica (crio-ME) con la inteligencia artificial (IA), estamos visualizando procesos biológicos a escala atómica, descubriendo detalles moleculares nunc...

bit.ly

🧵Una célula es una gran máquina con un montón de piezas. Conocer su estructura en 3D para entender cómo funcionan es la misión del Programa de Biología Estructural del #CNIOStopCancer. Y "la base para futuras terapias y aplicaciones", según su director, Óscar Llorca, @oscarllorca.bsky.social 👇🏻

Thrilled to share the updated video of my paper in Nature with Maciej (under supervision of @simonemattei.bsky.social & @jomaalab.bsky.social) Proud to use Cryo-ET to uncover how hibernation factors are key to translation restart! To model PTMs in situ and render animations fulfilled my PhD dream!🥹🎉

EMBL@embl.org · 3mo ago

Despite its name, SNOR, a newly discovered protein, is hardly asleep on the job. EMBL researchers’ newest technologies allowed their scientific collaboration to discover a tiny protein with a big role in awakening cells from dormancy to restart protein synthesis. www.embl.org/news/science...

With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar...

Added a little script to chimerax-trimmings to automate the creation of panels for model-map fit figures. It zones the map around (by default) 40aa parts of each chain (but doesn't cut in the middle of helices). Saves each as a png, metadata to csv. Saves each view as a scene for tweaking views.