Dr. @roisinmcmanus.bsky.social vom @dzne.science untersucht, wie Entzündungen im Gehirn gezielt reduziert werden können, um die Entwicklung von #Demenz zu verlangsamen. Im Mittelpunkt stehen sogenannte Mikrogliazellen, die bei Alzheimer eine wichtige Rolle spielen. ▶️ Infos zum AFI-Projekt im Video

Entzündungen im Gehirn und Alzheimer stoppen

YouTube video by Alzheimer Forschung Initiative

youtu.be

🥼 We’re looking for a #MSc student to work in our lab as part of their MSc thesis or internship on an interdisciplinary project @dzne.science, in Germany! 🧠 If you’re interested in #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad👇 jobs.dzne.de/en/jobs/1014...

Master student (f/m/x) in the field of Neuroimmunology 1447/2025/6

jobs.dzne.de

Can AI-designed binders degrade, aggregate, stain and enrich endogenous proteins in human cells? Check out our new preprint! www.biorxiv.org/content/10.1...

Transposon-Display of AI-designed binders enables manipulation of the proteome in human cells

Transposon-Display is a highly scalable screening method that links proteins to their encoding DNA during expression in E. coli via a mutant transposase. Leveraging this system, we identified AI-desig...

biorxiv.org

📢 We are #hiring a #PhD student to work on an interdisciplinary, collaborative project @dzne.science in Bonn, Germany! 🧠 If you’re interested in western diet-induced #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad below 👇 jobs.dzne.de/en/jobs/1014...

PhD student (f/m/x) in the field of Neuroimmunology 1439/2025/5]

jobs.dzne.de

Had a great time visiting @tcddublin.bsky.social last week where I got to share some of our new work from the lab! 🧠 Really enjoyed the discussions and meeting many amazing researchers, including some old friends 😊 Thanks to @David Loane and the TCD Biochemical society for the lovely invitation

Thrilled to be at #ADPD2025 in Vienna ☀️ Thanks to everyone who came to our session on innate immunity yesterday! Really enjoyed the discussions after on our findings on #metabolism & #microglia function in #alzheimer’s disease I’ve learned a lot at this meeting - looking forward to Copenhagen 2026 🧠

Intermittent Fasting Increases Sex Drive in Male Mice: An Approach for Low Libido in Humans? Current findings could point the way for new therapy option / Serotonin plays key role. Hot off the press from our Bonn based group of Dan Ehninger. 👉 www.cell.com/cell-metabol...

Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin

Xie et al. show that intermittent fasting (IF) enhances sexual behavior in male mice by reducing serotonergic inhibition through lower brain tryptophan. While IF does not improve endocrine function or...

cell.com

This month the McManus lab turns 1! 🎉 It’s been an amazing year, from starting out with an empty lab space to having our first co-authorships, grant awards and successful student projects 📄 Delighted to work with such a wonderful team of scientists on #alzheimersdisease and #dementia research 🧠

Visit the #exhibition "What the Health - One World. Your Health!" at the Museum Koenig in #Bonn. Check out the #events surrounding the exhibition and discover how your health and the health of the planet are connected 🌍 Learn more about the program here: bonn.leibniz-lib.de/de/ausstellu...

🚨 Apply now! We invite you to apply for this year's International School of Advanced Immunology taking place September 14 - 19 at Maria Laach, Germany. Visit our website for more information: www.advanced-immunology.net #international #school #immunology

Happy St Patrick’s Day! And what a lovely surprise from the lab, who all wore green this morning ☺️☘️

I am overjoyed to present our latest paper on Autophagy in CD8 Tcells! www.nature.com/articles/s41... It was, as all ‘sciencing’ is, a huge team effort. I will try to do it some justice in the following thread 😊 1/n @cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology

Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...

nature.com

Check out the latest episode from @immunosens.bsky.social where I chat about our research on #microglia, #NLRP3 and immunometabolism in #Alzheimer’s disease that was published this month in @cp-immunity.bsky.social

Cluster of Excellence ImmunoSensation@immunosens.bsky.social · last yr.

🎬 Episode 13 of #SpotOnScience is out! In this episode, Dr. Róisín McManus introduces her work on the new role of NLRP3 in Alzheimer's disease. Check out Spot on Science Episode 13: www.youtube.com/watch?v=5Hw2... #science #research #immunology #Alzheimer

Five days of indulging in chocolate bars, crisps and other junk foods can lead to lingering changes in brain activity, a study shows1. The resulting brain patterns are similar to those seen in people who have obesity. https://go.nature.com/3F61B4o

How a junk-food splurge can change your brain activity

A short bout of indulgence in fatty, sugary snacks leads to lingering brain-activity changes ― even if it does not cause weight gain.

go.nature.com

Happy to share our first review from the McManus lab! 🥳 Special thanks to my PhD student & 1st author @nehalonkar.bsky.social & our co-author & collaborator Eicke Latz 📄 We summarise the key role of #metabolism on microglial function in health & #neurodegeneration 🧠 pubmed.ncbi.nlm.nih.gov/39936491/

Neuroinflammation and immunometabolism in neurodegenerative diseases - PubMed

This review highlights the recent studies that have significantly contributed to our understanding of the metabolic dysregulation observed in activated microglia in conditions such as AD, unveiling no...

pubmed.ncbi.nlm.nih.gov

2nd Brazilian-German Immunology Workshop Vienna, Austria August 15-16, 2025 DEADLINE for application: March 1 Pls apply to Tim Sparwasser (sparwasser.office’at’uni-mainz.de) or Bernardo Franklin (franklin’at’uni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.

*Job Opportunity* Prof. Dominic Lemken is seeking a PhD candidate to research Consumer Behavior and Food Choices as part of our SFB! If you are passionate about #ConsumerBehavior and #FoodEconomics find out more here: www.uni-bonn.de/de/universit...

Another fantastic shot from @roisinmcmanus.bsky.social at the mechanisms of activation and modulation of the #NLRP3 inflammasome! Congratulations to the McManus team at the @dzne.science and my dear friends at the iii @unibonn.bsky.social! Fantastic work! www.cell.com/immunity/ful...

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression

How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

cell.com

Temple University @temple.edu in Philadelphia is recruiting for a Assistant or Associate Professor - Tenure Track Faculty to work on seeking Therapeutic targets for Alzheimer's Disease. Closing date: 9th March www.dementiaresearcher.nihr.ac.uk/job/assistan...

Assistant or Associate Professor: Therapeutic targets for Alzheimer’s

Temple University in Philadelphia is recruiting for a Assistant or Associate Professor - Tenure Track Faculty to work on seeking Therapeutic targets for Alzheimer's Disease.

dementiaresearcher.nihr.ac.uk

🎉 Huge congratulations to @roisinmcmanus.bsky.social and Michael Heneka on this exciting study uncovering a novel role for NLRP3 in regulating microglial metabolism and phagocytosis to promote Alzheimer’s disease progression www.cell.com/immunity/abs...

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression

How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

cell.com

Join us along with The Rainwater Charitable Foundation and CurePSP for #Tau2025, Apr. 24-25 in London or online! Be a part of the conversation as leading experts work to address the future of tau research. Register now: alz.org/Tau

Tau Global Conference | Alzheimer’s Association

Leading experts from academia, industry, philanthropy and government will meet to address the future of tau research. Learn more and register.

alz.org

Congratulations to @roisinmcmanus.bsky.social from DZNE in Bonn on her newly published paper in Immunity: "NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression" 👉 doi.org/10.1016/j.im... 👉 www.dzne.de/en/news/pres...

Lab Findings Support the Concept that Reducing Neuroinflammation Could Help Fight Alzheimer’s

New insights into immune cells in the context of neurodegeneration.

dzne.de

The UK Dementia Research Institute @UKDRI is seeking an outstanding established academic to take the position of Centre Director, at the level of Clinical or non-Clinical Professor at Cardiff University. Closing date: 20th March www.dementiaresearcher.nihr.ac.uk/job/centre-d...

Centre Director: UK Dementia Research Institute at Cardiff

The UK Dementia Research Institute are seeking an outstanding established academic to take the position of Centre Director, at the level of Clinical or non-Clinical Professor.

dementiaresearcher.nihr.ac.uk

Whether you feel a sudden urge to discuss your recent research findings OR have completely missed the abstract submission OR have just discovered this fabulous congress: Submit your Late Poster and/or register here: www.nwg-goettingen.de/2025/default... between 👉 03 – 20 February 2025 👈

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression: Immunity www.cell.com/immunity/ful...

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression www.cell.com/immunity/ful... @cp-immunity.bsky.social @roisinmcmanus.bsky.social

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression

How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

cell.com

I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1) www.cell.com/immunity/ful...

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression

How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

cell.com

Einladung zum Webinar zu #OpenAccess-Publikationskosten an alle, die 2025 in diesem Programm einen Antrag stellen wollen (bis 4. Mai): Antragsberechtigung, Förderbedingungen und Vorbereitung in der 2. Phase. ➡️ 21.02.25, 9:30 Uhr (Registrierung nicht nötig) Zugangslink: www.dfg.de/de/foerderun...

Förderprogramm: "Open-Access-Publikationskosten"

dfg.de

Then join the 7th Pint of Science in Bonn from May 19-21! Pint of Science gives you the opportunity to present your research in a simple and understandable way in front of an interested audience in a pub. It will be a fun night with quizzes, Q&As and beer. #science #pub #presentation #Bonn

Thanks a lot to #FEBS and the Norwegian bioscience society for hosting me and special thanks to @nathaliejuya.bsky.social and @emreyaksi.bsky.social for your hospitality!

Nathalie Jurisch-Yaksi@nathaliejuya.bsky.social · 2y ago

Decoding cilia signaling and function by the one and only @wachtenlab.bsky.social Thanks for delivering a fantastic #FEBS national lecture at the Norwegian bioscience society winter meeting.