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Sami Chaaban

@sami-c.bsky.social

Group Leader at the Francis Crick Institute starting January 2027. Currently postdoc in the Carter Lab (MRC-LMB), previously PhD in the Brouhard Lab (McGill University) https://sami-chaaban.github.io/

2 Posts204 Follower183 Folgt
Alister Burt@alisterburt.bsky.social · 5mo ago

tl;dr: MissAlignment learns to score misalignment then wiggles your alignments around to reduce that misalignment -> no more misalignment = high res STA 🌟 Watching @martenchaillet.bsky.social chip away at this was a real privilege! I’m excited to see this out and what you all will do with it 🙃

Dimitry Tegunov@dtegunov.bsky.social · 5mo ago

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

Alan Brown@alanbrownhms.bsky.social · 11mo ago

Our lab is seeking a Postdoctoral Fellow. The position is intentionally broad, as we are looking for outstanding researchers from diverse scientific backgrounds to advance our understanding of cilia and ciliopathies: academicpositions.harvard.edu/postings/15526

HMS - Postdoctoral Fellow in BCMP, Brown Lab

We invite applicants for a postdoctoral fellow position in the Brown lab at Harvard Medical School in Boston, Massachusetts. The Brown lab uses structural, biophysical, and biochemical approaches to d...

academicpositions.harvard.edu

Oli Clarke@olibclarke.bsky.social · last yr.

This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x

bioRxiv Biophysics@biorxiv-biophys.bsky.social · last yr.

High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles https://www.biorxiv.org/content/10.1101/2025.09.08.674935v1

Wieczorek Lab@mike-wieczorek.bsky.social · 2y ago

Happy to have contributed a small part to this exciting story about the ancestors of eukaryotic tubulin in Asgard archaea. Congratulations to all the co-authors!

Pilhofer Lab 🦠❄️🔬@pilhoferlab.bsky.social · 2y ago

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

Credit: Margot Riggi (@margotriggi.bsky.social), Max-Planck Institute of Biochemistry (@mpibiochem.bsky.social)
Javier Espadas@javierespadas.bsky.social · 2y ago

Extremely happy to see our work finally out!🎉 Great collaboration between @rouxlab.bsky.social @buzzbaum.bsky.social labs and a real pleasure to work and share co-first authorship with incredible scientists and friends @diorgeps.bsky.social @sami-c.bsky.social. Big thanks to the rest of the authors!

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 2y ago

New research on ancient Asgard archaeal ESCRT-III proteins reveals evolutionary secrets of membrane remodelling. Diorge Souza, Javier Espadas and Sami Chaaban, investigated the ESCRT-III proteins with Buzz Baum and Aurelien Roux. Read more: www2.mrc-lmb.cam.ac.uk/asgard-archa... #LMBResearch (1/2)

Evolution, structure and membrane remodelling function of the ESCRT-III superfamily in eukaryotes and their closest relatives Asgard archaea. The two subfamilies, B-type and A-type, have distinct structural properties to perform sequential steps of the membrane remodelling pathway.
Tim Stearns@stearnslab.bsky.social · 2y ago

How do great discoveries sometimes come from unexpected findings? It’s right there in the first paragraph of Fleming’s paper: a contaminated plate led to the discovery of penicillin. Much work was required to turn the discovery into practice, but this simple observation started it all.

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Ferdos Abid Ali@abidalilab.bsky.social · 2y ago

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪

This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.
samlacey.bsky.social@samlacey.bsky.social · 2y ago

Our review of Intraflagellar transport is out now! We cover lots of the recent advances in our understanding of IFT, and where we think there are still some gaps. www.nature.com/articles/s41...

The intraflagellar transport cycle - Nature Reviews Molecular Cell Biology

Intraflagellar transport (IFT) ensures delivery of selected proteins into cilia. The IFT protein complexes IFT-A and IFT-B polymerize at the base of the cilium to form an anterograde train that facili...

nature.com