@juruehle.bsky.social's PhD work is now out in Genome Biology 📚🧬 : Lentiviral single-cell MPRA of synthetic enhancers reveals motif affinity-based encoding of cell state specificity link.springer.com/article/10.1186/s13059-026-04186-9 Julia achieved three cool things with this work...🧵

Lentiviral single-cell MPRA of synthetic enhancers reveals motif affinity-based encoding of cell state specificity - Genome Biology

Background Cell state-specific gene expression programs emerge from the interplay between cis-regulatory elements (CREs), such as enhancers, and transcription factors (TFs). Massively parallel reporte...

link.springer.com

Ein Team von Forschenden aus dem DKFZ und HI-STEM hat einen vielversprechenden neuen Ansatz zur Behandlung von fortgeschrittenem Darmkrebs entdeckt. Sie identifizierten einen Marker für metastasierten Darmkrebs, der die Achillesferse besonders aggressiver Tumorzellen ist. t1p.de/wzspb

Neu entdeckter Marker für metastasierten Darmkrebs ist die Achillesferse besonders aggressiver Tumorzellen

Ein Team unter Leitung von Forschenden aus dem Deutschen Krebsforschungszentrum (DKFZ) und dem Stammzell-Institut HI-STEM* hat einen vielversprechenden neuen Ansatz zur Behandlung von fortgeschrittene...

t1p.de

Loss of the Y chromosome is linked with poor clinical outcomes in various cancers, including lung cancer. We set out to understand the molecular mechanisms behind this and found severe epigenetic deregulation at LOY's core. Read more about it here⬇️ #biorxiv #preprint www.biorxiv.org/content/10.6...

Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma #SingleCell 🧪🧬🖥️ https://www.biorxiv.org/content/10.64898/2026.06.02.729627v1

Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma https://www.biorxiv.org/content/10.64898/2026.06.02.729627v1

How do lineage-biased HSC states relate to each other? check out: rdcu.be/fkASJ in @natcellbio.nature.com Collaboration with @simonhaas.bsky.social @bihatcharite.bsky.social & MDC; Thomas Höfer & Daniel Hübschmann @dkfz.bsky.social @nct-heidelberg.bsky.social

In our new study, we identify stem cell kinetics and cellular competition as key principles underlying hematopoietic stem cell diversity. Fun collab@milsommick.bsky.social Florian Grünschläger@estherrodriguezc.bsky.social, Tamar Nizharadze, T. Höfer, D. Hübschmann(1/6) www.nature.com/articles/s41...

🧬🖥️ 🎬 Final take: Call for Talks - German Conference on Bioinformatics (#GCB2026) 📍 Saarbrücken, Germany | 🗓 22–25 September 2026 🔗 Details & submission: gcb2026.de/Programme/Ca... Lecture abstracts deadline: 3 May 2026 Poster abstracts deadline: 6 August 2026 (max. 150 – first come, first served!)

The next #ScienceatDKFZ event will take place on Monday, 20 April 2026, at 4 pm. In addition to the keynote lecture by Franziska Blaeschke, there will be four 5-minute short talks by DKFZ junior scientists on recent highlight publications. @blaeschkelab.bsky.social www.dkfz.de/en/news/even...

Dreaming of a career in cancer research? Join the International PhD Program at DKFZ - Germany’s largest biomedical research center. Explore #cancerresearch including #cancerbiology, #bioinformatics, #epidemiology & #medicalphysics. The Summer Selection is open now 👉 apply here: t1p.de/hl56b

Join us this summer in Frankfurt for outstanding science and a great community…….so easy to travel to, and Heidelberg is only a short train ride away if you want to visit our historic old town located on the Neckar river.

ISEH - International Society for Experimental Hematology@isehsociety.bsky.social · 5mo ago

Registration is open for #ISEH2026! Register now to secure the lowest rate. We look forward to welcoming you to Germany - willkommen! 👉️ iseh.org/Annual-Meeti...

Epigenetic dysregulation of IRF9 drives excessive #interferon signaling in #COPD By M. Llamazares-Prada, R. Jurkowska & colleagues @biomedx.bsky.social & Cardiff University 🗞️ doi.org/10.1038/s44321-026-00386-9

Ein Politiker sexualisiert Schulmädchen und die Republik greift die Frau an, die das öffentlich gemacht hat. Und ihr tut so, als würde euch Epstein schockieren. Das ist genau das Klima, das sowas überhaupt über Jahre hinweg ermöglicht hat.

The main project of my PhD 🧬🔬 is out: we developed single-cell lentiMPRA, a lentivirus-based method to measure enhancer activity and transcriptomes at single-cell resolution. We then applied sc-lentiMPRA to fully synthetic enhancers 🧩... 🔗 doi.org/10.64898/202...

Proud of @juruehle.bsky.social for getting her PhD paper on biorxiv! In it, we take synthetic enhancer screens to the single cell level, offering new insight into how transcription factors and enhancers interact 👀

Julia Rühle@juruehle.bsky.social · 5mo ago

The main project of my PhD 🧬🔬 is out: we developed single-cell lentiMPRA, a lentivirus-based method to measure enhancer activity and transcriptomes at single-cell resolution. We then applied sc-lentiMPRA to fully synthetic enhancers 🧩... 🔗 doi.org/10.64898/202...

Early bird registration is closing Feb 28! We will have an AMAZING party!

Lars Velten@larsplus.bsky.social · 8mo ago

ISCO (Innovations in Single-Cell OMICS) will be back in beautiful Barcelona! 🗓️ 28th/29th of May 2026 📍Barcelona Biomedical Research Park @prbb.org (beachfront!) Keynotes: @bartdeplancke.bsky.social and @bocklab.bsky.social Submit your abstract and present your research! www.isco-conference.eu

Una buena noticia para empezar el año 😊 El trabajo liderado por @larsplus.bsky.social, investigador del CRG, ha sido reconocido por la Asociación Española contra el Cáncer como uno de los avances de investigación más destacados de 2025.

La investigación del cáncer en 2025 | Contra el Cáncer

Descubre los proyectos y avances clave en investigación contra el cáncer que cuentan con el apoyo de la Asociación Española Contra el Cáncer en 2025

blog.contraelcancer.es

ONLINE FIRST ALERT! Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia aacrjournals.org/bloodcancerd... @aacrjournals.bsky.social #childhoodcancer #epigenetics #precisiononcology

Do not miss this conference!

Lars Velten@larsplus.bsky.social · 8mo ago

ISCO (Innovations in Single-Cell OMICS) will be back in beautiful Barcelona! 🗓️ 28th/29th of May 2026 📍Barcelona Biomedical Research Park @prbb.org (beachfront!) Keynotes: @bartdeplancke.bsky.social and @bocklab.bsky.social Submit your abstract and present your research! www.isco-conference.eu

If you are thinking where to do your Postdoc, I can only give my highest recommendations to join Lars and his team!

Lars Velten@larsplus.bsky.social · 9mo ago

We are looking for a postdoc to join our team! If you're interested in translating a cutting edge genomics technology (www.nature.com/articles/s41...) to real-life applications in hematology, this is for you. We offer a unique working environment ON THE BEACH: recruitment.crg.eu/content/jobs...

Do you teach #rstats? Do your students complain about how lame and old-fashioned dplyr is? Don't worry: I have the solution for you: github.com/hadley/genzp.... genzplyr is dplyr, but bussin fr fr no cap.

GitHub - hadley/genzplyr: dplyr but make it bussin fr fr no cap

dplyr but make it bussin fr fr no cap. Contribute to hadley/genzplyr development by creating an account on GitHub.

github.com

🚀 Thinking about your next big career step in science? The Int'l PhD Program at DKFZ could be a perfect fit for you. 🌍 Work in an international environment, with 500+ doctoral researchers 🔬 Do cutting-edge cancer research Curious? Join our online info session on 20 Nov. Register here: t1p.de/ws7q3

This was a lot of fun! Thanks Daylon and @arunsharmaphd.bsky.social for being great hosts!

Stem Cell Podcast@stemcellpodcast.com · 11mo ago

We have a new episode out! Dr. Lars Velten from the Centre for Genomic Regulation talks about his research on #LineageTracing and #hematopoiesis: https://bit.ly/4gsvo5X

DNA-methylation-based deconvolution can be a powerful tool for identifying novel disease subgroups. In our paper in Acta Neuropathologica, we show how this can be leveraged in IDH-mutant gliomas - specifically in oligodendrogliomas. doi.org/10.1007/s004...

DNA methylation analysis reveals an epigenetic signature distinctive of high-grade oligodendroglioma - Acta Neuropathologica

IDH-mutant gliomas represent a subtype of diffuse gliomas that primarily affect patients in early to mid-adolescence. These tumors are classified into three distinct CNS WHO grades of malignancy. Accu...

doi.org

#IRBBarcelona⁩ & ⁨@crg.eu scientists identify DNA “barcodes” that mark blood cell #aging—accelerating after 50. Published in @nature.com, the work could pave the way for preventive, personalized #antiaging therapies. https://youtu.be/ST5YmqqMcuQ @alejofraticelli.bsky.social  #AgingResearch 🧪

Enjoy the videos and music that you love, upload original content and share it all with friends, family and the world on YouTube.

youtu.be

Ein Team aus Forschenden vom BIH, @mdc-berlin.bsky.social, DKFZ, HI-STEM und @qmul.bsky.social hat eine Technologie zur Entschlüsselung der Immunzell-Kommunikation entwickelt. Damit lässt sich unter anderem ablesen, warum Immuntherapien bei manchen Menschen wirken bei anderen nicht. t1p.de/w3v16

Wie Immunzellen kommunizieren, um Krankheiten und Krebs zu bekämpfen

Ein interdisziplinäres Team aus Wissenschaftlerinnen und Wissenschaftlern vom Berlin Institute of Health in der Charité (BIH), vom Max Delbrück Center, dem Deutschen Krebsforschungszentrum (DKFZ), dem...

t1p.de

Excited to share our latest paper @natmethods.nature.com We present a high-throughput framework to map cellular interactions at ultra-high scale – broadly applicable from whole-organism immune response mapping to personalized therapy response prediction (1/4). www.nature.com/articles/s41...

Integrative spatial and multi-omic profiling in bladder cancer links L1 retrotransposition to extrachromosomal DNA, genomic instability, and viral mimicry response https://www.biorxiv.org/content/10.1101/2025.07.30.667694v1

Do you want to improve our understanding of therapy resistance induced by epigenetic heterogeneity? Do you have a PhD in Molecular Biology or related fields? Join us as a (fully-funded) Postdoc in the Division of Cancer Epigenomics at DKFZ. More information here: www.dkfz.de/en/cancer-ep...

Out in Leukemia (@natureportfolio.nature.com). Hypomethylating agents (HMAs) such as decitabine are used in clinical practice for the treatment of Acute Myeloid Leukemia and expected to re-activate tumor suppressor genes de-activated by aberrant DNA methylation.