Rationalizing Heterogeneity in Staphylococcus aureus Bacteremia: Current Progress and Future Goals ✅ Just Accepted 🔗 https://bit.ly/4vTJLHo

Bringing #AMR into the outcome assessment of duration trials with the new DOOR-FRAME is very welcome! Larger samples and systematic AMR assessment among participants will be likely required to prove benefit academic.oup.com/ofid/article... #IDSky #AMSsky Awesome work by @seanong.bsky.social et al

Excited to share an article that I've long awaited to share seeking to answer: What is the right dose of cephalexin/cefadroxil for SSTIs? We reviewed clinical studies & conducted PTA sims to elucidate this #IDSky @absteward.bsky.social accpjournals.onlinelibrary.wiley.com/doi/10.1002/...

Getting It Right the Second Time: How Can we Optimize First‐Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?

Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies ...

accpjournals.onlinelibrary.wiley.com

ESCMID 2026 highlights COBRA Trial – One day is enough Dutch RCT: 1 day of antibiotics after ERCP drainage for cholangitis was non‑inferior to 4–7 days. Bottom line: Antibiotic durations can safely be much shorter once source control is achieved. #IDSky clarityinitiative.org/escmid-2026-...

Clarity Initiative

Clinical Literature Appraisal and Research education in InfecTious diseases

clarityinitiative.org

📣 New publication: Andes hantavirus outbreak on a cruise ship - an ESCMID Emerging Infections Subcommittee (EIS) rapid assessment www.clinicalmicrobiologyandinfection.org/article/S119...

Andes hantavirus outbreak on a cruise ship - an ESCMID Emerging Infections Subcommittee (EIS) rapid assessment

The ongoing cluster of hantavirus infections associated with the cruise ship MV Hondius represents an unusual but instructive event at the intersection of zoonotic spillover, human mobility, confined ...

clinicalmicrobiologyandinfection.org

Highlights from ESCMID Global 2026? @gurujosh.bsky.social asked CLARITY faculty: @angelahuttner.bsky.social @erinmccreary.bsky.social @marcbonten.bsky.social @seanong.bsky.social @ashabowen.bsky.social and others (not on BlueSky). #IDSky clarityinitiative.org/escmid-2026-... Any that we missed?

Clarity Initiative

Clinical Literature Appraisal and Research education in InfecTious diseases

clarityinitiative.org

We looked at empiric B-lactam antibiotics in MRSA bacteraemia and BC persistence and AKI, using CAMERA2 dataset. Groups: none, early (only empiric B-lactam), late (only after trial enrolment), throughout (empiric and after enrolment). #IDSky www.clinicalmicrobiologyandinfection.org/article/S119...

🔥 💥Late-Breakers |COBRA RCT 1-day of antibiotic treatment after adequate endoscopic biliary drainage is non-inferior to 4-7 days in adults with acute cholangitis. 💡 Shorter is better+source control Practice-changing? #ESCMIDGlobal2026 #idsky

Nice presentation from @seanong.bsky.social about DOOR/Radar at #ESCMIDGlobal2026 My main worry is lower ranked components dominating Sarah Walker discussed this issue in her excellent Bradford Hill lecture (recording in link)

The 3rd and 4th commentaries on recent ID trials are up on the CLARITY website (we aim to publish in depth reviews of important ID stuies). This time looking at the GAMECHANGER trial: clarityinitiative.org/commentaries... @erinmccreary.bsky.social with Ahmad Mourad @gurujosh.bsky.social #IDSky

How Do We Win? The GAME CHANGER Trial

Erin K. McCreary, PharmD (1), Ahmad Mourad, MD MHS (2, 3)

clarityinitiative.org

New article about how to manage Staphylococcus aureus bacteremia. Led by Hadar Mudrik-Zohar. Includes @seanong.bsky.social @drtoddlee.bsky.social #IDSky #SNAP_trial www.sciencedirect.com/science/arti...

Navigating the Challenges in Staphylococcus aureus Bloodstream Infection: A Practical Guide to Management

sciencedirect.com

A group of ID clinical researchers passionate about clinical research and evidence appraisal has just launched the CLARITY initiative (clarityinitiative.org), which aims to improve the generation and interpretation of evidence in ID and Microbiology.

Clarity Initiative

Clinical Literature Appraisal and Research education in InfecTious diseases

clarityinitiative.org

Our new paper in @cmijournal.bsky.social: www.clinicalmicrobiologyandinfection.org/article/S119... We use the BALANCE and CAMERA2 trials as case studies to illustrate the use of the different methods available for analysis of hierarchical composite endpoints. #IDSky @steventong.bsky.social

Comparing different methods for analyzing hierarchical composite endpoints: two illustrative case studies with post-hoc analyses of the BALANCE and CAMERA2 randomized clinical trials.

Hierarchical composite endpoints (HCEs) are increasingly being used in infectious disease research. In this paper, we illustrate different methods for analyzing HCEs in post-hoc analyses of the BALANC...

clinicalmicrobiologyandinfection.org

The draft for the 2026 IDSA/ESCMID clinical practice guidelines on 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴 bacteraemia is now available for public consultation. Get your copy of the manuscript and submit your feedback before 15 December 2025. https://ow.ly/HZao50XwVYg #IDSky #clinmicro

@seanong.bsky.social is giving his PhD oration today at 12.30pm AEDT. If you are free, you will learn heaps about clinical trials in infectious diseases. It's been an incredible PhD journey! unimelb.zoom.us/j/8944229688... @thedohertyinst.bsky.social

New Research Accounting for non-adherence to assigned antibiotic treatment duration for bloodstream infection (BALANCE): a post-hoc analysis of a randomised clinical trial www.thelancet.com/journals/lan...

Accounting for non-adherence to assigned antibiotic treatment duration for bloodstream infection (BALANCE): a post-hoc analysis of a randomised clinical trial

Non-adherence in BALANCE was significantly associated with a range of important prognostic factors, which might have introduced bias. Causal inference methods addressing this bias showed a consistent ...

thelancet.com

Hot off the press at @thelancetinfdis.bsky.social: our paper diving into non-adherence in the BALANCE trial. We identify factors associated with protocol non-adherence, and evaluate the impact of potential bias on trial results. authors.elsevier.com/a/1m5He5E-Uo... @steventong.bsky.social #IDSky

We are looking for candidates for a new fully-funded joint PhD position at the Universities of Toronto and Melbourne, working on RCTs in bloodstream infection (BALANCE+, SNAP, STRAP). More info here: forms.gle/H9TXEMkwM1cb... Please spread far and wide! @steventong.bsky.social #IDSky

I owe a lot to the site formerly known as Twitter (it's where I found my amazing joint PhD position thanks to a fortuitous post by @steventong.bsky.social), but it's completely unusable now and full of irrelevant material that I don't want to see. I no longer use it, and am firmly Team BlueSky!

Ilan Schwartz@germhuntermd.bsky.social · 10mo ago

New pro/con perspective piece by @drneilstone.bsky.social & yours truly Joining the X-odus: Contrasting perspectives on whether infection specialists should leave X (formerly Twitter) That I'm sharing it here belies where I stand on the issue www.cmi-comms.org/article/S295... #IDSky

David Paterson and the ADVANCE-ID team are doing a lot of work for us summarizing recent literature on bacterial & fungal infections & therapies. If you aren't already receiving their bimonthly newsletters, you should! ad-id.co/subscribe #IDSky #Clinmicro

Our new paper in @cmijournal.bsky.social led by the brilliant Hadrien Moffroid, a junior colleague in Melbourne. We examined international funding flows in ID RCTs published in selected high-impact journals over a 10-year period. doi.org/10.1016/j.cm... @steventong.bsky.social #IDSky

New post-hoc Camera-2 📷 post-hoc analysis out today regarding adherence to quality metrics in MRSA bacteremia. Compared to similar non-trial population w/ MRSA bacteremia: -No difference in 🪦, BUT -non-trial had less following of quality metrics (see ⬇️) #IDSky jamanetwork.com/journals/jam...

Quality-of-Care Indicator Adherence and Mortality Outcomes in MRSA Bacteremia

This post hoc analysis of a randomized clinical trial investigates whether patient participation in clinical trials is associated with practitioner adherence to methicillin-resistant Staphylococcus au...

jamanetwork.com

Glad to have the opportunity to collaborate with Spanish colleagues on this. We conducted a pooled Bayesian post-hoc analysis of the BACSARM and SAFO trials evaluating combination therapy with fosfomycin for SAB. The door may not be closed on adjunctive fosfomycin! Justifies need for more RCTs.

Clinical Infectious Diseases@cidjournal.bsky.social · last yr.

Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post-hoc Analysis of Individual Participant Data from Two Randomized Trials ✅ Just Accepted #IDSky

Thankful for another opportunity to write this editorial with @steventong.bsky.social in @jama.com: jamanetwork.com/journals/jam... We discuss this trial, which evaluated the impact of different recruitment letter formats on RCT enrolment: jamanetwork.com/journals/jam...

Trials Within Trials—Optimizing the Delivery of RCTs

In the latest issue of JAMA, Johansen and colleagues1 report the results of a trial that investigated the impact of digital recruitment letter formats on recruitment to a larger clinical trial, the DA...

jamanetwork.com

Our review on hierarchical composite endpoints (HCEs) has just been published in @cidjournal.bsky.social: doi.org/10.1093/cid/... We provide a conceptual overview of HCEs, explain the different associated target parameters and analytic methods. @steventong.bsky.social @gurujosh.bsky.social

Making sense of hierarchical composite endpoints in randomized clinical trials – a primer for infectious disease clinicians and researchers

Hierarchical composite endpoints (HCEs) are increasingly being used in infectious diseases research. In this review aimed at educating the clinical reader,

doi.org

Making sense of hierarchical composite endpoints in randomized clinical trials – a primer for infectious disease clinicians and researchers @seanong.bsky.social @gurujosh.bsky.social @steventong.bsky.social and colleagues Open Access #IDSky #MedSky academic.oup.com/cid/advance-...

Honoured to be invited to write this commentary with @steventong.bsky.social, on an excellent target trial emulation study which showed that antibiotic use was not associated with improved outcomes in non-severe COVID-19. jamanetwork.com/journals/jam... #IDSky

Target Trial Emulation for Antibiotic Use in Acute COVID-19

This study by Pulia and colleagues1 reports results from a large population-based cohort using target trial emulation to examine the associations of antibiotic treatment with clinical outcomes in pati...

jamanetwork.com

🆕 Evaluating BSI in Ontario we found #AMR was associated with a 10% ⬆️ risk of death equivalent to 1.2 deaths/100,000 people/year These estimates are lower than those in previous literature, which may be due to robust adjustment for confounding doi.org/10.1093/cid/... @cidjournal.bsky.social

Evaluating Harms Associated With Prolonged Antibiotic Duration of Therapy in Community-Dwelling Older Adults: A Cohort Study Using Instrumental Variable Analysis #IDSky

Evaluating Harms Associated With Prolonged Antibiotic Duration of Therapy in Community-Dwelling Older Adults: A Cohort Study Using Instrumental Variable Analysis

Shorter courses of antibiotic therapy are increasingly recommended to reduce antibiotic exposure. However, quantifying the real-world impact of duration of therapy is hindered by bias common in observational studies.

academic.oup.com

Cefazolin vs Antistaphylococcal Penicillins for Treatment of Methicillin-Susceptible Staphylococcus aureus Bacteremia: A Systematic Review & Meta-Analysis @connorprosty.bsky.social @seanong.bsky.social &c Cefaz more effective, safer #idsky www.clinicalmicrobiologyandinfection.com/article/S119... 🔓