#ResultatScientifique🔎| Comment la forme des cellules façonne l’intestin ? Une étude révèle le rôle des forces mécaniques dans la protection de cette barrière ▶️ buff.ly/ph86JyC ✍️ @deniskrndija.bsky.social 📕 @natcomms.nature.com 🤝 @cnrs.fr @cbitoulouse.bsky.social

Quand la forme des cellules fragilise la barrière intestinale

L’intest

buff.ly

New Toettchlab paper alert! Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration. www.cell.com/cell-systems...

Heterochronic limb patterning in marsupials reveals flexibility in the processes underlying lateral plate mesoderm morphogenesis | Science Advances www.science.org/doi/10.1126/...

Heterochronic limb patterning in marsupials reveals flexibility in the processes underlying lateral plate mesoderm morphogenesis

Accelerated limb formation in marsupials reveals canonical developmental landmarks aren’t strict prerequisites for initiation.

science.org

Come join us! 🔬🐣 The Piacentino Lab at Johns Hopkins @hopkinsmedicine.bsky.social is recruiting a postdoc to study membrane lipids, cell migration, and invasion in neural crest and embryonic models! @socdevbio.bsky.social @ascbiology.bsky.social #devbiol #cellbio #lipids

If George von Dassow (an alum of our grad program, natch!) is on a paper, you know the microscopy is gonna be stunning.

Journal of Cell Biology@jcb.org · 2w ago

Michaud, @andrewgoryachev.bsky.social, von Dassow, @xenresearchcenter.bsky.social et al. identify a versatile cortical pattern-forming circuit based on #Rho, F-#actin, Ect2, & RGA-3/4 rupress.org/jcb/article/... 📕 In "Collective Behaviors and Self-Organization in Cells" rupress.org/jcb/collecti...

Happy #FluorescenceFriday! 🔥🧪🔬 A blaze of neural crest cells migrates through a developing quail embryo on one of embryonic development's most epic journeys. Beautifully captured by @vanderspuy.bsky.social 👩‍🔬🐣 #Devbio

New paper 🧵 What if the "landscape" that guides cell differentiation isn't fixed, but is sculpted, in real time, by the very cells moving through it? We call this a 'sandscape' : grains of sand that carve dunes as they move, while the dunes' shape simultaneously steers where the grains go next.

New in @dev-journal.bsky.social: how tissue shape tells cells what to become Using human stem-cell neuruloids, we show how that physical boundaries encode positional information that drives cell fate patterning in a model of trunk formation A thread 🧵 journals.biologists.com/dev/article/...

Boundary constraints can determine pattern emergence

Summary: A reaction-diffusion mechanism recapitulates pattern emergence in an in vitro model of neuromesodermal progenitors under a variety of boundary and geometrical perturbations.

journals.biologists.com

Pleased to share our latest! We show that the chick limb can be directed to recapitulate key stages in mammalian evolution, providing a unifying model for digit patterning across amniotes. Preprint: www.biorxiv.org/content/10.6... Video summary: www.youtube.com/watch?v=fvL_...

Transforming avian to mammalian modes of digit patterning

How a conserved embryonic organiser-the Sonic hedgehog (Shh)-expressing Zone of Polarising Activity (ZPA)-generates diverse limb architectures in amniotes remains a central problem in evolutionary and...

biorxiv.org

New in @natmethods.nature.com: a new human stem cell model of EMT lets us watch cells transition in both 2D and 3D and shows human stem cells can undergo the transition differently depending on how they are grown. 🔗 https://doi.org/10.1038/s41592-026-03096-9

(1/15) Thrilled to share new Evo-Devo work where we address the molecular, cellular & morphometric basis of an extreme axis segmentation program in the Japanese eel — an animal that forms 120 vertebrae.

Please check out our new preprint! Together with @sarathomasy.bsky.social and led by DVM/PhD candidate Raneesh Ramarapu, we used 3D imaging + quantitative analysis to show how the corneal endothelium maintains a stable layer and refines hexagonal packing during development.

bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · 3mo ago

Quantitative imaging of corneal endothelial development reveals dynamic but resilient monolayer https://www.biorxiv.org/content/10.64898/2026.05.01.722310v1

An important topic (certainly close to our hearts): how slightly different progenitors may cooperate and synergize to produce robust collective decisions. Thanks, Alfonso, for putting these different pieces of work into perspective!

Alfonso Martinez Arias@amartinezarias.bsky.social · 3mo ago

A clear/significant finding derived from the single cell (sc) analysis of biological systems has been the realization that phenotypically homogeneous populations are heterogeneous at the level of gene expression (GE). www.cell.com/fulltext/S00... 🧵

A clear/significant finding derived from the single cell (sc) analysis of biological systems has been the realization that phenotypically homogeneous populations are heterogeneous at the level of gene expression (GE). www.cell.com/fulltext/S00... 🧵

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

Gene expression is a fundamentally stochastic process, with randomness in transcription and translation leading to cell-to-cell variations in mRNA and protein levels. This variation appears in organis...

cell.com

More insights into junctional neurulation using the bird embryo as a model system! 🐣

Melanie D. White@melaniedwhite.bsky.social · 3mo ago

I'm SO excited to see this new paper from our lab's first PhD graduate @wangjianxiong.bsky.social. An outstanding student with a promising career ahead! A PCP-independent role for Prickle1 in junctional neural tube formation. 🧪🐣 Check it out: www.nature.com/articles/s41...

Excited to share our new publication on the mechanics of cranial neural tube closure. A really enjoyable and fruitful collaboration bridging Developmental Biology and biophysical modelling. Take a look here! www.cell.com/current-biol...

Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis

Pérez-Verdugo et al. show that hindbrain neuropore closure is driven by surface ectoderm actomyosin purse-string tension and active migration. These forces create reproducible patterns of cell elongat...

cell.com

Excited to start a new chapter with my team’s relocation to the Pink City, at @cbitoulouse.bsky.social! Looking forward to new scientific interactions on campus (@laas, LPT, IRIT, ANITI…) at the interface of biology, physics & computational science. @cnrsbiologie.bsky.social @occitanie.bsky.social

I started Awesome Life Science Resources: a curated list of resources on work culture, career, and communication for life scientists. Built for PhD students, postdocs, and PIs. Check it out: github.com/jjfroehlich/...

Please check out our new preprint! Using single cell analysis paired with HCR to visualize transcript localization we have identified cell and tissue-specific expression of various genes encoding tubulins, kifs, and dyneins during neural crest development!

bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · 5mo ago

A spatial and temporal atlas of tubulin isotype expression during neural crest EMT https://www.biorxiv.org/content/10.64898/2026.03.04.709627v1

Happy to share this work from Carlos Camacho de la Maccora that reveals how rates of posterior progenitor addition and anterior vacuolation are balanced across the notochord. With Alberto Ceccarelli and @osvaldo-chara.bsky.social we present a model of long-range communication to provide robustness.

We‘re looking for a motivated Master student to join our team! Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬 Then please apply! #optogenetics #metabolism #devbio #hESCs Please RT. Thank you!🙏

Institute of Molecular Biotechnology@imbavienna.bsky.social · 6mo ago

Apply to the Master’s project position at IMBA: https://www.oeaw.ac.at/imba/career-education/open-positions/pos2607-masters-project #research #jobs #europe #biology

Group Leader Call at the @cbitoulouse.bsky.social in Genome biology, projects at the interface with devbio will be given particular attention. please share :) cbi-toulouse.fr/wp-content/u...

So excited to share that my 1st paper is published!! Read all about how to manipulate the #MechanicalProperties of tissues using our custom built TiFM! journals.biologists.com/dev/article/...

TiFM2.0 – versatile mechanical measurement and actuation in live embryos

Summary: Precisely-controlled, sensitive cantilevers measure and perturb tissue forces and mechanical properties in their native locations in live embryos, providing a useful tool to study tissue mech...

journals.biologists.com

Excited to finally share the final/final.doc version of our paper. It's been a journey, but very proud of the result. Well done to all involved, especially @elsieplace.bsky.social @kchinnaiya.bsky.social , @thomasdwkim.bsky.social, @sethblackshaw.bsky.social 👏👏 www.nature.com/articles/s41...

Resolving forebrain developmental organisation by analysis of differential growth patterns - Nature Communications

Experiments on the embryonic chick brain reveal distinct directional growth patterns and a tripartite hypothalamus, challenging the classic segmented prosomere model and offering an updated view of ho...

nature.com

@devdynamics.bsky.social Welcome to Bluesky Developmental Dynamics, added to the Developmental Biology starter pack II. You can also patch in to more #DevBio folks by checking out the first Developmental Biology start pack here: go.bsky.app/M5AgJhn

As 2025 comes to a close, my university (Dalhousie U in Halifax, Canada) is recruiting faculty, including outstanding early career researchers, and Canada Research Chairs. Applications are due January 19 2026 (was just notified today!). Please repost.

Dalhousie University is recruiting up to 30 tenure and tenure-track faculty positions

Backed by the Government of Canada’s $1.7 billion Global Impact+ Research Talent Initiative, Dalhousie University is undertaking one of the most ambitious research-leader recruitment efforts in its hi...

dal.ca

📣 #Job alert! Looking to establish your own independent research in cell biology, development or evo-devo? The @cnrs.fr is recruiting 7 scientists in that area of research. Here are updated unofficial guidelines. Reach out to members of the committee if you have questions c3n-cn.fr/section-24-w...

CNRS@cnrs.fr · 8mo ago

#JointheCNRS 🫵 Want to push the boundaries of science? The CNRS is recruiting passionate researchers (F/M)! The campaign runs until January 12, 2026. 👉 carrieres.cnrs.fr/en/external-... #Recruitment #CNRS #Innovation #Research #Icicarecrute

Excited to share a fantastic PhD opportunity combining interdisciplinary approaches with me, @alexgfletcher.bsky.social and @rorylcooper.bsky.social sky.social! Please share!

Rory Cooper@rorylcooper.bsky.social · 9mo ago

🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬 This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share! www.findaphd.com/phds/project... 🧪

📣Our project, “Mechanometabolic Control of Vertebrate Limb Elongation,” has been funded by Wellcome! Over the next 8 years, we’ll collaborate with @manningresearch.bsky.social and Nathalie Agar’s group to understand the mechanics of ECM-rich mesenchymal tissues! Funded positions available!🎉

And another great gut epithelium story from our cool neighbors !!!😎 @cbitoulouse.bsky.social

Denis Krndija@deniskrndija.bsky.social · 10mo ago

Ever wondered how adult organs preserve epithelial barrier integrity while continuously exposed to mechanical stress? We tackled this question in our new preprint – led by our brilliant PhD student Vishnu Krishnakumar! (1/11) 🔗 www.biorxiv.org/content/10.1...