Shabaz Lab
@shabazlab.bsky.social
Focus on developing proteomics technologies. https://www.chem.ox.ac.uk/people/shabaz-mohammed https://www.bioch.ox.ac.uk/research/mohammed https://scholar.google.co.uk/citations?hl=en&user=6FdXeiwAAAAJ&view_op=list_works&sortby=pubdate
Join Professor Philipp Kukura FRS for the Clifford Paterson Prize Lecture on 9 February. He will describe the development of mass photometry, a method that measures the mass of molecules and viruses: royalsociety.org/science-even... @kavlioxford.bsky.social
Introducing a phospho-switch for allosterically regulating target proteins in response to ERK kinase activity. @toettch.bsky.social www.nature.com/articles/s41...
Design and optimization of a kinase-controlled allosteric switch - Nature Methods
This Article introduces a phospho-switch for allosterically regulating target proteins in response to ERK kinase activity.
nature.com
My article is published but I have to ask a co-author for the pdf because Wiley decided it was too expensive for them to email an author's copy
🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15). 🔗 www.biorxiv.org/content/10.6...
We have a new preprint!!! Our very talented PhD student Tom McGirr, along with our outstanding collaborators, show that translational attenuation is critical for avoiding proteotoxic stress upon exposure to ionizing radiation. #RNASky, #RNA, www.biorxiv.org/content/10.6...
GIGYF2/4EHP-Mediated Translational Attenuation Maintains Cellular Homeostasis Following Ionizing Radiation
Translational regulation is a critical component of the cellular response to environmental stress. Ionizing radiation (IR) exists naturally at low doses (e.g., cosmic rays and radioactive materials) b...
biorxiv.org
Update: very happy to announce we added @victoryin.bsky.social and Hans Wessels to our lineup of instructors. Our PhD course Advanced Proteomics for Drug Discovery and Biotherapeutics happens in September, still some spots available. Register now: www.eventbrite.nl/e/advanced-p...
I am thrilled to share that our work evaluating - deep breath - UVPD, ECD, AI-ECD, sceHCD (sceCID really), and EID for glycopeptides is out now! pubs.acs.org/doi/10.1021/...
Evaluating the Performance of Photon- and Electron-Based Fragmentation Methods in Omnitrap-LCMS Analysis of N-Glycopeptides
To date, collision-induced dissociation and methods based on electron transfer dissociation are considered the ‘best’ approaches for the mass spectrometry analysis of N- and O-glycopeptides, respectiv...
pubs.acs.org
Wordle 1,835 5/6 ⬛⬛⬛⬛⬛ ⬛⬛⬛🟨⬛ 🟨🟨⬛⬛⬛ ⬛⬛⬛⬛⬛ 🟩🟩🟩🟩🟩 Another doozy. Doozy would have been an easier word.
When it comes to reviews, I have a high resistance level to performing experiments that prove obvious points. I have died on this hill many times and I will continue sabotaging myself on this point.
(ACS Anal Chem) [ASAP] Large-Scale Stereolithography Precision Manufactured Solid Cone-Jet Emitters for Electrospray Mass Spectrometry: Analytical ChemistryDOI: 10.1021/acs.analchem.6c02479 #MassSpecRSS #ACSAChem
[ASAP] Large-Scale Stereolithography Precision Manufactured Solid Cone-Jet Emitters for Electrospray Mass Spectrometry
Analytical ChemistryDOI: 10.1021/acs.analchem.6c02479
dlvr.it
Between 1985--2023, MIT's faculty grew 9%. Administrative staff grew 189%. 📈 Why? In new @pnas.org paper, we use dynamical system model to show administrative bloat can emerge without empire-building--just from well-intentioned problem-solving gone awry www.pnas.org/doi/10.1073/...
🔬 New preprint from KPL ApS: Arg-C Zero, recombinant arginyl endopeptidase with >99% cleavage efficiency, R-P bond cleavage, acid-compatible labile PTM workflows, and histone analysis without derivatization. 📄 doi.org/10.64898/202... 🛒 kplbio.com/arg-c-zero/ #Proteomics #MassSpec #PTM #Enzymes
(MS Reviews) Carlito B. Lebrilla: Building Instruments, Fields and Opportunities From the Ground up: Mass Spectrometry Reviews, EarlyView. #MassSpectromRev #MassSpecRSS
Carlito B. Lebrilla: Building Instruments, Fields and Opportunities From the Ground up
Mass Spectrometry Reviews, EarlyView.
dlvr.it
Well, its out. Honored to play a small part in this huge project using multi-omics to profile human biology and variations at unprecedented scale. www.sciencedirect.com/science/arti... Thanks to a great team of co-authors and collaborators! @fbmh-uom.bsky.social @uom-dcs.bsky.social
A comparison of deep multiomics profiles across ethnicity, geography, and age
Despite extensive research, molecular differences in human populations and the influence of ancestry, age, geography, and diet are poorly understood. …
sciencedirect.com
We've just published a preprint describing GlyComboCLI, a command-line tool for glycan composition assignment in MS data. Open-source, FAIR-compliant, and built for integration into automated bioinformatic workflows. #glycotime Link: www.biorxiv.org/content/10.6...
Meet Chris Crittenden, our most recent #FacesOfMassSpec feature. At @Genentech, Chris uses tandem mass spectrometry to support clinical candidates while also championing mentorship and scientific collaboration. https://bit.ly/3RaRCRu
Meet Chris Crittenden, our most recent #FacesOfMassSpec feature. At @Genentech, Chris uses tandem mass spectrometry to support clinical candidates while also championing mentorship and scientific collaboration. https://bit.ly/3RaRCRu
Short write-up of our journey. Searching for T cell transcription factors, Marc v/d Wetering stumbled across Wnt signaling. Vladja Korinek linked Wnt to colon cancer and crypt biology. Nick Barker discovered the gut stem cell. Toshi Sato invented organoids authors.elsevier.com/a/1n3No6tu0C...
Our new study characterises the assembly of two functionally distinct chloroplast protein import complexes (TOC-P and TOC-N) in the outer membrane of plant chloroplasts. Huge thanks to @Ivan Ahel's lab and @sykhalid.bsky.social's lab, for a fantastic collaboration! www.biorxiv.org/content/10.1...
biorxiv.org
Congratulations to Bjarne Feddersen for his work on benchmarking umbrella sampling workflows for PMF calculations of membrane permeation! Systematic work that provides guidance on how to approach these to minimise compute resource. @oxfordbiochemistry.bsky.social. pubs.acs.org/doi/10.1021/...
Umbrella Sampling Workflows for Fast-Converging PMF Calculations without Artificial WHAM Constraints
Umbrella sampling is a powerful tool to investigate the underlying free-energy landscapes that govern the permeation properties of small molecules through complex lipid bilayers. However, obtaining co...
pubs.acs.org
Watching the football in the UK and I just witnessed an Eli Lilly funded advert about 'obesity awareness'....... we did get this with 'labido stuff' read viagra too but not sure if that was internet only... Anyway, not sure what to make of it. No 'Ask your physician' stuff thankfully.
(JASMS) [ASAP] Investigating the Efficiency of Ultraviolet Photodissociation in Peptides Modified with N-Terminal UV-Absorbing Chromophores: Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00389 (RSS) #MassSpecRSS #JASMS
[ASAP] Investigating the Efficiency of Ultraviolet Photodissociation in Peptides Modified with N-Terminal UV-Absorbing Chromophores
Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00389
dlvr.it
Como join us next Monday 11th at @cnicproteomics.bsky.social for a surely inspiring talk by @slavov-n.bsky.social ! #singlecell #proteomics
Nikolai Slavov@slavov-n.bsky.social · 3mo agoNext Monday (May 11), I will be in Madrid to share our research. I will present results from @parallelsq.bsky.social and @slavovlab.bsky.social, including our latest proteomic technologies and the biological questions they are answering.
Super excited that our SEE-CITE photoaffinity labeling method is now out in @natchem.nature.com rdcu.be/ffBSC. Here we introduce a custom silyl ether cleavable linker between a diazirine photocrosslinker handle and molecules of interest to streamline site-of-labeling analysis for PAL chemoproteomics
Congratulations to all the 2026 ASMS Award Recipients! We look forward to celebrating you at #ASMS2026 in San Diego. Learn about the 2026 awardees: https://www.asms.org/about-asms-awards #TeamMassSpec
High‐Throughput Single‐Cell‐Resolved Spatial Proteomics Enabled by an Ordered Colloidal Crystal Column onlinelibrary.wiley.... --- #proteomics #prot-paper
