Excited to share my piece in @nature.com Careers on why scientists are already trained for AI, plus ten places to start. 🧑‍🔬🤖 www.nature.com/articles/d41... Hope it helps! 🙏 Incredibly grateful to editors Jack Leeming and @jperkel.bsky.social for the opportunity and collaboration.

Want to get more from AI? Treat every prompt like an experiment

Taking a scientific approach to artificial-intelligence queries makes every output a result to be checked, says James Dewar. Here are ten tips for doing it right.

nature.com

Delighted to announce #RecombMechanisms is back for its 3rd edition next July! This conference will bring together leaders in the fields of DNA recombination (mitotic & meiotic), repair, replication, transcription, epigenetics, and cancer biology. Sign up for updates now➡️https://bit.ly/4pFcLAq

The Ly Lab is recruiting two #postdocs to study intercellular DNA transfer. Join us to tackle fundamental questions at the intersection of genome instability, cell-cell communication, and cancer evolution. Please share! 🙏 Full posting: cri.utsw.edu/careers/

Excited to share the first preprint from my lab! Transcription has been implicated in regulating SMC complex function, but how this works has been unclear. Here, we use a yeast quiescence model to examine how transcription targets condensin.

bioRxivpreprint@biorxivpreprint.bsky.social · 3w ago

Asymmetric condensin loop extrusion is regulated by RPA-coated single-stranded DNA in quiescent cells https://www.biorxiv.org/content/10.64898/2026.07.10.737861v1

Happy to share our latest paper in NAR showing that the 2B sub-domain is a general dimerization domain for the UvrD-family of SF1A helicases including Rep and PcrA, led by Binh Nguyen in collaboration with Eric Galburt's group. doi.org/10.1093/nar/...

Happy to share the first preprint from our lab, led by @arrosan.bsky.social, in collaboration with @ccb-lab.bsky.social. We identify a conserved cohesin-interacting motif in Red1 required for its recruitment, DSB formation, and Mek1 activation. www.biorxiv.org/content/10.6... #meiosis #recombination

Cohesin–axis interaction via a conserved Red1 motif promotes domain-specific DSB formation and Mek1 activation

Faithful chromosome segregation during meiosis I requires tight control of interhomolog recombination. In budding yeast, the meiotic chromosome axis, built on Rec8-containing cohesin together with Red...

biorxiv.org

🚨 Preprint alert 🚨 Excited to share our latest bioRxiv preprint introducing DeepDiffusion, a tool for analysing facilitated 1D diffusion! 🔗 Preprint: www.biorxiv.org/content/10.6... (1/3)

DeepDiffusion: a Physics-Informed Neural Network for Heterogeneous Facilitated 1D Diffusion

Single-molecule fluorescence microscopy combined with optical tweezers has enabled the direct observation of diffusing proteins on tethered DNA. These and complementary techniques reveal facilitated o...

biorxiv.org

Preprint alert! Using smFRET, we define the only essential ATP hydrolysis step in translation initiation. We show that eIF3 and eIF4B stimulate ATP-hydrolysis-dependent recycling of cap-stalled eIF4F, coupling eIF4F recycling to PIC loading onto an mRNA.🔬 doi.org/10.64898/202...

I feel like Messi should let somebody else score

The first paper from my postdoc, looking at how tension activates DNA cleavage by the endonuclease ANKLE1, is out in @narjournal.bsky.social. ANKLE1 processes ultrafine bridges, persisting linkages between chromosomes that can lead to catastrophic DNA ruptures. (1/3) doi.org/10.1093/nar/...

Happy to share that I will be joining the Biology Department and Holden Comprehensive Cancer Center at University of Iowa as an assistant professor in summer 2027! My lab will study how recombination is regulated to prevent non-allelic repair and genome rearrangements, and their relation to cancer.

Excited to finally share our preprint on mapping the genetic interaction network of the DNA damage response with combinatorial knockout screens led by Sam Hayward, Alina Vaitsiankova, and Tomas Lama-Diaz! www.biorxiv.org/cgi/content/...

Mapping the genetic landscape of the DNA damage response with Cas12a-based combinatorial knockout screens

The DNA damage response (DDR) is a complex network of cellular pathways that ensures the faithful maintenance of our genomes upon a wide array of genomic insults. To elucidate the functional architect...

biorxiv.org

How does a DNA repair enzyme find a needle in a haystack? 🧬 Our latest paper in NAR, led by the one and only C-trap queen Kaitlin Dehart, uses single-molecule imaging to watch APE1 scan DNA and lock onto AP-sites. @lumicks.bsky.social academic.oup.com/nar/article/...

A dynamic search mechanism enables APE1 to identify AP-sites in DNA

Abstract. Apurinic/apyrimidinic (AP) sites are among the most frequent DNA lesions, arising thousands of times per cell each day. These lesions threaten ge

academic.oup.com

Here is a link to my student Mitch's final published paper on the activity of Rad51 and Rad54 during the homology search. genesdev.cshlp.org/content/40/1...

Awesome work! Still so much to learn about ribosome hibernation!

Ahmad Jomaa@jomaalab.bsky.social · 3mo ago

Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...

Excited to share a preprint of my review: "How Topoisomerases Relax and Disentangle the Genome During DNA Replication" 🧬🪢🧵✂️🙏 papers.ssrn.com/sol3/papers....

Happy to share our new review in @annualreviews.bsky.social on abasic sites and their impact on DNA replication written by @angelotaglialatela.bsky.social. www.annualreviews.org/content/jour...

Endogenous Sources of Abasic Sites and Implications for DNA Replication: Mechanisms of Fork Stalling and Recovery

Apurinic/apyrimidinic (AP) sites, also known as abasic sites, are among the most frequent DNA lesions, arising spontaneously or as intermediates in base excision repair. Their structural impediment to...

annualreviews.org

Here is the work of Jingyi Hu and David Moraga graduate students in my lab, published online in Plos Genetics journals.plos.org/plosgenetics...

Potential Rad54 separation of function mutation highlights unique roles during homologous recombination

Author summary Homologous recombination (HR) is a DNA double-strand break repair pathway that functions at DNA breaks and stalled or collapsed replication forks. Rad51 is a critical enzyme that mediat...

journals.plos.org

I’m so honored to be included in this Hypothesis Fund cohort and grateful for this investment in our research! 🥲

Hypothesis Fund@hypothesisfund.bsky.social · 4mo ago

📣 Bold science alert! We're thrilled to announce our latest awardees who are pushing the boundaries of research in aging, regeneration, and bacterial resilience. bit.ly/HFAwardees Hear from the #HFScouts who championed these talented scientists👇 in our 🧵: 1/

5/ Awardee @heatherfeaga.bsky.social is investigating how bacteria decide when to go dormant💤 (ie, form spores). Her project could lead to important new advancements in the management of spore-forming bacteria in the environment, hospitals, & food supply. 🎉 Congrats Dr. Feaga! 🙏 #HFScout Dipti Nayak

Very exciting that our new paper on the forces exerted by the Rad51-Rad54 homology search complex is now online. This was a collaborative effort with the Wang here at Cornell, and this work performed primarily by a graduate student, Mitch Woodhouse genesdev.cshlp.org/content/earl...

Very proud of this tour de force from two former students, Stephanie Tanis and Leah Simon, with help from a huge team, including @charlesdanko.bsky.social highlighting a novel-overlooked intervention point for male contraception www.pnas.org/doi/10.1073/...

Meiotic prophase I disruption as a strategy for nonhormonal male contraception using small-molecule inhibitor JQ1 | PNAS

Developing safe, reversible, and nonhormonal male contraceptives has been hindered by the lack of defined biological windows that can be transientl...

pnas.org

I mean WTAF?

There are so many places that are warm right now, and yet it is snowing in Ithaca...

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.

Sequence and chemical specificity define the functional landscape of intrinsically disordered regions - Nature Cell Biology

Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...

nature.com

Alex Holehouse@alexholehouse.bsky.social · 2y ago

We’re pleased to share our substantially updated (more below on that…) version of our manuscript exploring the relationship between conservation in sequence/function for intrinsically disordered regions (IDRs) www.biorxiv.org/content/10.1...

2026 is turning into a real banger

Living in Ithaca New York you learn there are many different kinds of snow

Happy to share our perspective on the DNA translocation mechanism by the CMG helicase. DNA translocation by the CMG helicase: the helical inchworm model url: portlandpress.com/biochemsoctr...

rince & JB Editor's Choice: Lin, Prince & Feaga identified sporulation genes via analyzing almost 1500 genomes. They show that that an unusual membrane-localized variant of Spo0B is found throughout Paenibacillaceae. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology