Honored to have been awarded the Yamaguchi Medal at the 10th World Congress of Biomechanics in Vancouver. Deeply grateful to APAB, my lab members, mentors, and collaborators! Privileged to present our lab’s recent work and connect with colleagues. #WCB2026 #APAB @mbisg.bsky.social, Physiology, NUS

New preprint We identify a conserved intramolecular interaction in KANK proteins. We show that the KANK KN domain contains separable functional modules: the LD motif mediates talin binding, while residues 60-68 mediate interaction with the KANK ankyrin repeat domain doi.org/10.64898/202...

Force-dep. FHL2 localization to stress fibers induces actomyosin contractility & atherosclerosis-like phenotypes in endothelial cells–new paradigm for mechanochemical feedback Shailaja Seetharaman @sseethar.bsky.social Margaret Gardel @squishycell.bsky.social et al link.springer.com/article/10.1...

Mechanosensitive FHL2 tunes endothelial function via microtubule-actomyosin crosstalk - The EMBO Journal

Endothelial tissues are essential mechanosensors in the vasculature, and defects in their response to mechanical cues such as blood flow can lead to endothelial dysfunction and cardiovascular diseases...

link.springer.com

new role for FAT1 beyond being a protocadherin: a mechanotransduction mediator.

LabSoap@labsoap.bsky.social · 10mo ago

This week #JournalClub @cellpress.bsky.social #membrane #pressure #Hippo #density www.sciencedirect.com/science/arti...

Okay want to talk blebs, migration, life and more!!! I will be at poster session (sunday) at 2 PM at poster board- 247 at @ascbiology.bsky.social #Cellbio2025

Almost 40 years later, has anyone identified what "buttonin", the 75-kD protein that decorates microtubule like buttons, is? dx.doi.org/10.1083/jcb.104.6.1553

1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social : "Self-organization of tumor heterogeneity and plasticity" biorxiv.org/content/10.1... Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated? A thread👇

We hire! The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities. More details here: cytomorpholab.com/index.php/jo...

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

Emerging mechanomedicines informed by mechanotransduction along the integrin–cytoskeleton–nucleus axis pubs.aip.org/aip/apb/arti...

Emerging mechanomedicines informed by mechanotransduction along the integrin–cytoskeleton–nucleus axis

Mechanical forces are fundamental to the formation of normal biological tissues and the maintenance of physiological health. These forces are transmitted from t

pubs.aip.org

We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum. First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social rdcu.be/ezBl7

Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model

Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...

rdcu.be

Congratulations to Thomas Callister, Peter Lu (@petery.lu), Aditya Nandy, Ludwig Schneider, Shailaja Seetharaman (@sseethar.bsky.social), Colm Talbot, Madeleine Torcasso, and Yihang Wang!

Final presentations for Physiology 2025 were last weekend; the students did an awesome job. @sseethar.bsky.social, @andyletzhang.bsky.social, @squishycell.bsky.social, and I were all very proud 🤩.

Excited to be starting my research group as a tenure track Presidential Young Professor at the Mechanobiology Institute @mbisg.bsky.social, and the Dept of Physiology at @nusingapore.bsky.social in the fall! More about our work on vascular mechanobiology in health & disease mechano-medicine-lab.com

The first objective of IMBA is to make its scientists successful. Let us help you turn ideas into discovery! IMBA is hiring a Junior Group Leader in the molecular life sciences. Apply below. #hiring #biology #research #groupleader #europe

🌿✨ Calling all mechanobiologists, bioengineers, and curious minds! ✨🌿 Join us in Vietnam this year for an unforgettable Conference on Mechanobiology, where science meets culture in one of Southeast Asia’s most vibrant destinations. 📅 06-12 July 📍 Quy Nhon, Vietnam 🔗 icisequynhon.com/conferences/...

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

Join us Friday April 11 for talks by David Hathcock @davidhathcock.bsky.social (Mechanisms for dissipation-enhanced adaptation & cooperative sensing in bacterial chemotaxis) & Shailaja Seetharaman @sseethar.bsky.social (Mechanosensitive LIM domain protein FHL2 tunes endothelial function) #biophysics

Awesome work showing a super clean + thoughtful application of using genomic deep learning models for discovery. Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model www.cell.com/cell-genomic...

Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model

Dalal et al. show how AI can be used to systematically uncover the sequence rules that guide how signaling pathways interact with DNA inside cells. This work provides a new lens for discovering the co...

cell.com

IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.

Mike Sheetz (1946-2025) made immense contributions to our understanding of motor proteins, membrane biology, cytoskeleton and mechanobiology. Haguy Wolfenson, Gregory Giannone, and Martin Schwartz recall his life and work: rupress.org/jcb/article/...

How does the #vasculature regulate #immune cell infiltration & function across different brain tumors? 🧠🧪 Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻 🧵 @cp-immunity.bsky.social www.cell.com/immunity/ful...

Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...

Measuring and manipulating mechanical forces during development - Nature Cell Biology

This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...

nature.com

Looking for EGFR shrna plasmid urgently if someone has it🙏 if you could please check your connections it would be great as well! Thank you

As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration www.biorxiv.org/content/10.1...

CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration

Cells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the...

biorxiv.org

Hot from the press: #CellMigration #vesicles #organelles Jeppesen et al @mag2art.bsky.social lab introduce blebbisomes: organelle-rich motile vesicles, have immune checkpoint inhibitors, released by #cancer cells & used for #cellcomm @naturecellbiology.bsky.social www.nature.com/articles/s41... 🧪🔬

New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵 www.biorxiv.org/content/10.1...