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Steffen Grosser

@steffengrosser.bsky.social

Postdoc Junior Leader Fellow @Fundació ”la Caixa”, at Xavier Trepat Lab, IBEC Barcelona

10 Posts99 Follower185 Folgt
Artur@arturruppel.bsky.social · 6mo ago

First paper as first & corresponding author, out in PLOS Computational Biology! 🎉 napariTFM brings traction force & monolayer stress microscopy into napari, accessible via GUI; open-source, validated and no coding required. 😉 Check it out 👇

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Miranda Hunter@mrndhntr.bsky.social · last yr.

My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...

Mechanical confinement governs phenotypic plasticity in melanoma - Nature

Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...

nature.com

Ulrich Schwarz@ulrichschwarz.bsky.social · last yr.

📢Conference alert📢 Only one week left to register for the Engineering Life 2025 Symposium at Dresden September 1-3. This year's edition focuses on the function of mechanical forces in biology. engineering-life-dresden.de

Engineering Life 2025: ORIGIN AND FUNCTION OF MECHANICAL FORCES IN BIOLOGY

Engineering Life 2025, biological forces, force spectroscopy, measuring forces, developmental forces, molecular motors, forces in morphogenesis, cytoskeleton, DNA mechanics, bionanotechnology

engineering-life-dresden.de

Hyman Lab@hymanlab.bsky.social · last yr.

Great success for Dresden and Saxony! Physics of Life is one of the excellence clusters ‪@poldresden.bsky.social‬

TU Dresden@tudresden.bsky.social · last yr.

These Clusters will be funded: 🔹CARE: Climate-Neutral & Resource-Efficient Construction 🔹CeTI: Centre for Tactile Internet with Human-in-the-Loop  🔹ctd.qmat: Complexity, Topology & Dynamics in Quantum Matter 🔹@poldresden.bsky.social 🔹REC2: Responsible Electronics in the Climate-Change Era

Leo Otsuki@leootsuki.bsky.social · last yr.

Positional memory has implications for bioengineering. Transplanting salamander cells in a way that alters their spatial organisation changes signalling topology and results in predictable (but amazing) phenotypes such as too many fingers - or even extra limbs! 🧵3/14

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Microplastics Sommelier@leastactionhero.bsky.social · 2y ago

einstein sent this to curie in 1911 when she was being harassed by tabloids. it contains everything you’d want in such a letter: (1) your haters are trash (2) you’re a baller, a true queen (3) i have determined the statistical law of motion of the diatomic molecule in planck’s radiation field 🧪⚛️

Prague, 23 November 1911 Highly esteemed Mrs. Curie, Do not laugh at me for writing you without having anything sensible to say. But I am so enraged by the base manner in which the public is presently daring to concern itself with you!? that I absolutely must give vent to this feeling. However, I am convinced that you consistently despise this rabble, whether it obsequiously lavishes respect on you or whether it attempts to satiate its lust for sensationalism! I am impelled to tell you how much I have come to admire your intellect, your drive, and your honesty, and that I consider myself lucky to have made your personal acquaintance in Brussels. Anyone who does not number among these reptiles is certainly happy, now as before, that we have such personages among us as you, and Langevin(3) too, real people with whom one feels privileged to be in contact. If the rabble continues to occupy itself with you, then simply don't read that hogwash, but rather leave it to the reptile for whom i
Prasad Jallepalli, MD, PhD@prasad.bsky.social · 2y ago

this is a good time to note that the proposed candidate for NIH director has never run a lab, cared for patients, led a major research and healthcare institution, or been a principal investigator on an NIH grant

Steffen Grosser@steffengrosser.bsky.social · 2y ago

The spheroid fusion analysis I did in this new study is much better than in my old paper! I don't "fit" any dumb-bell 2D shape anymore to the data (unstable). Instead, I use moment analysis/aspect ratios, which can be converted to tissue fluidity (very robust).

Josquin Courte, PhD@josquincourte.bsky.social · 2y ago

@steffengrosser.bsky.social, who performed tissue fluidity analysis. and Calvin Lam, who performed, ages ago, the first simulations of a potential circuit for tissue elongation!

Josquin Courte, PhD@josquincourte.bsky.social · 2y ago

This circuit can be used to propagate a change in cell fate in 2D in a wave-like pattern… And also in 3D! In this animation, a spheroid of “sender” cells (red+green=yellow) is fused with a spheroid of “transceiver” cells. Activated transceivers become green.