The @agencerecherche.bsky.social 2026 results are in (pdf link): anr.fr/fileadmin/aa.... Wowowowow I got funded! @stefvass.bsky.social and I got founded! Drinks are on me!

Excited to share our latest work linking Cdc42 waves to mitotic cell size sensing and spindle length. www.science.org/doi/10.1126/...

🔬🚀 Updated #VLab4Mic preprint. Rebuilt the clathrin models from full-length triskelions, dome+flat lattice toy simulations share a common motif. Wanna see how it looks across microscopy methods? (Thank you for the advice @stefvass.bsky.social) www.biorxiv.org/content/10.64898/2026.06.02.729521v3

link.springer.com/article/10.1...

A coordinated transcriptional program controls de novo Golgi biogenesis - The EMBO Journal

The Golgi apparatus expands during differentiation and increased secretory demand, yet the transcriptional mechanisms governing its biogenesis remain poorly defined. To investigate this process, we de...

link.springer.com

Want to hear about axons, endo-exocytosis, and fancy microscopy? My recent talk to the Helmholtz Information & Data Science School For Health is available on youtube:

HIDSS4Health-Lecture: The Axonal Cytoskeleton Down to the Nanoscale

YouTube video by HIDA

youtube.com

The architecture of carriers formed by AP3:ARF1 for lysosomal membrane protein transport: www.science.org/doi/10.1126/.... Work from @jggkaufman.bsky.social, in collaboration with @dgershlick.bsky.social and David Owen. @mpibiochem.bsky.social @thecimr.bsky.social

Architecture of clathrin-independent AP3:ARF1-coated carriers

AP3 generates clathrin-free carriers on endosomes by organizing via ARF1 dimers into elongated membrane-deforming arrays.

science.org

@mhakala.bsky.social shows that HRS forms bidimensional condensates onto endosomal membranes to flatten clathrin/ESCRT-0, an observation unexplained since the 2000s. Thx to Kukulski lab, @stefvass.bsky.social @colomlab.bsky.social @kaksonen.bsky.social @mishakudryashev.bsky.social rdcu.be/fihKk

Great to see this new review on super-resolution approaches to study the cytoskeleton doi.org/10.1016/j.jare.2026.04.056 And very glad to see our correlative STORM/PREM images of endocytic “clearings” with @christlet.bsky.social highlighted doi.org/10.1126/science.ado2032

New perspective on caveolae www.nature.com/articles/s41...

A lipid-centric view of endocytosis by caveolae - Nature Cell Biology

This Perspective discusses the mechanisms underlying both the formation and scission of caveolae, with a focus on highlighting the role of specific lipids in regulating and coupling these processes.

nature.com

A review on Super-resolution Structured Illumination Microscopy (SIM) to study endocytosis: pubs.acs.org/doi/10.1021/... Featuring our live-cell SIM of proximal axons showing frozen clathrin-coated pits within clearing of the spectrin mesh (doi.org/10.1126/scie...)

Glad to see this out in the open! Preprint from Anna Brachet and colleagues from @iins-bordeaux.bsky.social looking at the relative organization and roles of ßII-/ßIII-spectrin in the dendritic membrane-associated periodic skeleton (MPS), including cool MINFLUX data: doi.org/10.64898/202...

Here's a hint...

Tune in next Thursday and listen to @wiesner-t.bsky.social awesome project on exocytosis along the axon shaft!

Canadian Neuroscience Seminars – Postdoctoral Series (CNS-PDS)@cns-pds.bsky.social · 4mo ago

A reminder: next Thursday, our monthly webinar will be taking place as usual. To join us, kindly register via us06web.zoom.us/webinar/regi... To stay updated on our webinars, events, and more. Subscribe to our mailing list here: t.co/Oa9dLowy1h

Beautiful EM image but check that perfect clathrin-coated pit photobombing the shot...😂

Cytoskeleton Journal@cytoskeljournal.bsky.social · 5mo ago

Happy #fluorescencefriday! Today we have the back cover of our latest issue of #CYTOSKELETON. Have a look at the entire issue here: onlinelibrary.wiley.com/toc/19493592...

#VAMP7-dependent late endosomal #secretion of #ER and #mitochondrial proteins impacts the #tumor #microenvironment and #macrophage engagement www.nature.com/articles/s41...

Our article on how to use micropatterned presynapses-on-glass is out in its final form in the latest issue of the Journal of Neuroscience @sfnjournals.bsky.social: www.jneurosci.org/content/46/8... The cover went to the special section on social neuroscience, so here's our #notthecover attempt

Gotta love Nature's opinion pieces "Science funding needs fixing - but not like that" "Academic publishing is broken - but publishing less is not the solution" "AI will kill science - how can researchers use it to be more efficient?"

FCHo2, not talin, enables inside-out activation of integrin ɑvβ5 in curved adhesions www.nature.com/articles/s41...

A menagerie of COS cells for #MicroscopyMonday 🧪

My personal obituary for Richard Hynes now live on the Manchester Cell-Matrix Centre website. www.manchester-matrix.org/news/profess...

This is finally out in J Neuroscience! A micropatterned presynapse-on-glass approach to resolve the nanoscale architecture and function of presynapses www.jneurosci.org/content/earl...

Deciphering the nanoscale architecture of presynaptic actin using a micropatterned presynapse-on-glass model

Chemical synapses are fundamental units for the transmission of information throughout the nervous system. The cytoskeleton allows to build, maintain and transform both pre- and postsynaptic contacts,...

jneurosci.org

Christophe 🔬 Leterrier@christlet.bsky.social · 2y ago

We have a new preprint out! Check how we developed a new presynapse-on-glass model based on micropatterns to reveal the functional nano-architecture of presynapses: doi.org/10.1101/2024... (1/7)

Excited to share our work engineering caveolin-derived nanoparticles “caveospheres”. We show their use for targeted transfection in cultured cells and effective targeted delivery and tumor killing in vivo. pubs.acs.org/doi/full/10....

A Modular Encapsulation System for Precision Delivery of Proteins, Nucleic Acids, and Small Molecules

Targeted nanoparticles have the potential to revolutionize therapeutics for medical applications. Here, we demonstrate the utility of a flexible precision nanovesicle delivery system for functional de...

pubs.acs.org

🚨The Neurocyto lab is branching out in our latest preprint! We used tubulin microinjection to directly visualize microtubule turnover in developing hippocampal neurons, demonstrating the presence of in-lattice repair and a selective stabilization in the nascent axon. Check below, or read on 🧵 1/9

Direct labeling of microtubule turnover reveals in-lattice repair and stabilization patterns in developing neurons

The microtubule cytoskeleton is the backbone of neuronal morphogenesis, driving the development of the dendrites and axon, and supporting trafficking to distant compartments. How neuronal microtubules...

biorxiv.org

Latest paper is now out and features on the cover of Science Advances 👉 tinyurl.com/vea5862x Very grateful Igor Bonacossa Pereira, Dat Le & Massimo Hilliard @hilliardlab.bsky.social for their creativity & passion. Read more about it 👉 tinyurl.com/56awjda5 & 👉 tinyurl.com/2vp8p8uk

An epidermal membrane-associated periodic skeleton restricts endocytosis to stabilize neuron-epidermal attachment and preserve axons

An epidermal membrane periodic scaffold protects axons from damage.

tinyurl.com

What a great start for 2026 for the EVICAT team!!! Everything you need to know about extracellular vesicles' recipient cells and how to harness these pathways for therapeutic purposes Thanks to all co-authors! bit.ly/3N9InyW

Biology and therapeutic potential of extracellular vesicle targeting and uptake - Nature Reviews Molecular Cell Biology

Extracellular vesicles are released from almost all cell types and mediate intercellular communication by delivering proteins, nucleic acids and lipids. This Review examines extracellular vesicle upta...

bit.ly

A tribute to Stuart Kornfeld, pioneering #glycotime scientist whose work on mannose-6-phosphate receptor lysosomal trafficking (among many other contributions) was highly influential to our work 🫡 www.jci.org/articles/vie...

New paper out! We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution. Huge congrats to Aurélie Favarin, Rayan Said, & all authors! In Science Advances: www.science.org/doi/10.1126/... #actin #myosin #mechanobiology

Optogenetic SH3 nanoclustering of SRC and HCK uncovers the functional specificity of these redundant kinases in macrophages. https://www.biorxiv.org/content/10.64898/2025.12.27.692121v1

A comprehensive article for our unique Live-to-HPF CLEM workflow in Scientific Reports!🔬❄️ Thanks to all who supported our long journey! Images are taken @ImagoSeine @ijmonod.bsky.social @imagerie-gif.bsky.social @i2bcparissaclay.bsky.social @jeoleurope.bsky.social www.nature.com/articles/s41...

Combining the CryoCapsule, HPM live µ and R221 conductive resin to track endosome from live imaging to electron microscopy using high-pressure freezing - Scientific Reports

Scientific Reports - Combining the CryoCapsule, HPM live µ and R221 conductive resin to track endosome from live imaging to electron microscopy using high-pressure freezing

nature.com

@natcellbio.nature.com - Finally out! Skin cells mechanically protect their genome from UV by positioning melanin above nucleus. Keratin filaments & microtubules drive the process. Led by Silvia Benito-Martinez & @laurasalavessa.bsky.social @membramics-lab.bsky.social www.nature.com/articles/s41...

Keratin intermediate filaments mechanically position melanin pigments for genome photoprotection - Nature Cell Biology

Benito-Martínez, Salavessa and colleagues show that keratin intermediate filaments and microtubules control the three-dimensional perinuclear position of melanin-containing organelles, shielding the D...

nature.com