TDvaliLab

@tdvalilab.bsky.social

Excited about centrosomes, centrioles, cell division, germline, and everything related....

🥳 Our new paper on C2CD3 is out in @plosbiology.org With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET. Big congrats to @ebertiaux.bsky.social and all involved.

PLOS Biology@plosbiology.org · 10mo ago

How does C2CD3 contribute to distal appendage formation in centrioles? @centriolelab.bsky.social show that C2CD3 acts as a central architectural organizer of the distal #centriole, bridging the luminal distal ring complex & peripheral appendage sites @plosbiology.org 🧪 plos.io/496XZuH

C2CD3 localizes to a ring structure observed in the lumen of the distal centriole by in situ cryo-electron tomography. Top: Confocal image of an expanded mouse photoreceptor cell immunolabeled for tubulin (magenta) and C2CD3 (green). DC, daughter centriole; BB, basal body; TZ, transition zone; CC, connecting cilium. Scale bar: 500 nm. Middle: In situ cryo-tomogram slices taken along the longitudinal axis of the centriole and connecting cilium. White arrowheads indicate microtubule triplets, black arrowheads indicate microtubule doublets, orange arrowheads mark the luminal ring structure, and yellow highlights the membrane. Scale bar: 50 nm. Bottom:  Model of the architecture of the distal region of the human centriole.

So called microtubule organizing centers (MTOCs) are not "organizing centers". They don't control their position (network center), nor MT orientation, length and shape (network shape). The actual organizers are MTs, molecular motors and regulators of MT +ends. MTOCs nucleate MTs. Let's rename MTOCs.

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We have PhD and Postdoc positions open in our group. Join us in Lausanne to explore how cells pull off extreme shape changes and how cilia drive biological flows. You can find more details on the projects available and how to apply in our website: www.epfl.ch/labs/lpl/joi...

Join us !

We are looking for creative and motivated scientists at to join the group. We are recruiting candidates from various scientific backgrounds including, but not limited to: biophysics, physics, biochemi...

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