A novel personalised mortality risk prediction tool for HIV-associated cryptococcal meningitis could lead to future treatment stratification trials - less intensive regimens for less unwell patients? Our new manuscript. www.thelancet.com/journals/lan... #IDsky #HIV #GlobalHealth #meningitis #fungal

Tom Samuels@thomashasamuels.bsky.social · last yr.

Very excited to share our new piece of work in the Lancet Global Health @lancetgh.bsky.social – Periskope-CM, a set of personalised risk prediction tools for HIV-associated cryptococcal meningitis mortality: www.thelancet.com/journals/lan... #IDsky #HIV #GlobalHealth #meningitis #fungal 1/8

Very excited to share our new piece of work in the Lancet Global Health @lancetgh.bsky.social – Periskope-CM, a set of personalised risk prediction tools for HIV-associated cryptococcal meningitis mortality: www.thelancet.com/journals/lan... #IDsky #HIV #GlobalHealth #meningitis #fungal 1/8

Fantastic piece of work by @richarddriley.bsky.social and others - this is the next step we need to be taking when we report the performance of clinical prediction models.

Richard Riley (R²)@richarddriley.bsky.social · 2y ago

**NEW BMJ PAPER** "Uncertainty of risk estimates from clinical prediction models: rationale, challenges, and approaches" - most models provide just a risk estimate - we argue for presenting associated uncertainty too - includes pros, cons, PPIE & methods Hope helpful! www.bmj.com/content/388/...

New research article in The Lancet Microbe Assessment of MpoxPlex, a high-throughput and multiplexed immunoassay: a diagnostic accuracy study www.thelancet.com/journals/lan... #IDSky #ClinMicro #ViroSky #Mpox #OpenAccess #OA

🆕💫 Analysis of AMBITION RCT Individuals started ART w/in 2 wks before presenting with cryptococcal meningitis, presumably active cryptococcal infection, have higher mortality, whereas those presenting on ART for > =2 wks have a more favorable prognosis #idsky academic.oup.com/cid/advance-...

Interesting to #IDSky & #ClinMicro

Anna Kildemoes@akildemoes.bsky.social · 2y ago

FINALLY! Our discovery of a very specific and sensitive serological target for schistosomiasis diagnostics is UP. Please, enjoy our shout-out for glycans and the importance of anticipating diagnostics needs 🧪🩸🪱 journals.asm.org/doi/10.1128/...

Ever wonder about the basis for fear-mongering & conspiracy theories about mRNA vax? Wish you had a place to go when someone cites "proof"? I've got you covered! In my latest @plos.org I buckle up for the waves of anti-vax muck likely to come in 2025. 1/2 absolutelymaybe.plos.org/2024/12/28/g...

Getting Ready for More mRNA Vaccine Fear-Mongering: A Compendium - Absolutely Maybe

Recently, I wrote about a depressingly successful campaign against the introduction of a next generation Covid vaccine in Japan. It is a…

absolutelymaybe.plos.org

Great piece in the Lancet Microbe from colleagues at HTD and RIPL about the vaccinating for dengue in travellers! 👏🏻 www.thelancet.com/journals/lan... Full details of how to go about it all for Uk travellers in the excellent Green Book travelhealthpro.org.uk/media_lib/ml... #IDSky #ViroSky

New dengue vaccine for UK travellers: recommended only for those with a previous infection

Dengue virus is the most abundant and rapidly spreading arbovirus worldwide. 390 million dengue infections are estimated to occur annually, of which approximately 25% are symptomatic.1 Climate change and urbanisation have contributed to the spread of the vectors (Aedes mosquitoes) and enabled sustained transmission in regions that were previously not affected.2 Although the burden of the disease is largely confined to Asia and central or south America, autochthonous spread has been increasing in central and southern Europe.

thelancet.com

Potential delivery of some antibiotics too? Clearly there may be some significant issues with volume of fluid to be delivered subcutaneously! #OPAT #IDSky #clinmicro #AMR

Science Magazine@science.org · 2y ago

A high-capacity microneedle patch powered by osmotic pressure can steadily release drugs over 24 hours in animals and is well-tolerated in people, offering a more convenient and portable alternative to current #DrugDelivery systems. Learn more in #ScienceTranslationalMedicine: scim.ag/400iaaj

Fatal Case of Crimean-Congo Hemorrhagic Fever, Portugal, 2024 #IDSky #EpiSky

Fatal Case of Crimean-Congo Hemorrhagic Fever, Portugal, 2024

Fatal Crimean-Congo Hemorrhagic Fever, Portugal

wwwnc.cdc.gov

Our letter about HLH in murine typhus has just been published in the Journal of Infection! doi.org/10.1016/j.ji.... Many thanks to my co-authors, with a special mention to Sophie Skarbek, Sana Sharrack, and @jamesmeiring.bsky.social for all your efforts 🙏

Hi @mattfrieman.bsky.social - TL;DR - our key conceptual advance is that different blood transcriptional biomarkers discriminate early and late phases of infection as a result of cell-specific epigenetic regulation and have important translational applications for respiratory virus infections:

Check out our paper on RNA biomarkers in COVID-19 MX1 expression occurred early in infection before PCR detection…potential role to stratify treatment #IDSky

Mahdad Noursadeghi@mnoursad.bsky.social · 2y ago

Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...

Poignant frontline perspective of a #Rwandan physician responding to the recent #marburg outbreak. It is well worth a read. We are are two weeks into the 42 day countdown to declaring the outbreak over🤞🏾. These brave HCPs kept us safe. #medsky #idsky 🧪 www.nejm.org/doi/full/10....

Fight or Flight — Facing the Marburg Outbreak in Rwanda | NEJM

Having diagnosed two ICU patients with the first known cases of Marburg virus disease in Rwanda, a physician must prioritize limiting spread, despite pleas for transfer from the patients’ families.

nejm.org

Fantastic session at #Medplus in the @rcphysicians.bsky.social today chairing cases from the Imported Fever Service with Sarah Logan. Thanks a bunch to all our panelists and speakers, you were all brilliant. If you’re at Med+ or joining online and missed it, do watch it back!