An immunobiliary single-cell atlas resolves crosstalk between type 2 conventional dendritic cells and γδ T cells in cholangitis

Nature Communications - Primary sclerosing cholangitis (PSC) is an autoimmune condition affecting the liver. Here, the authors generate an immunobiliary transcriptomic atlas and show that dendritic...

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Microplastics, nanoplastics and liver disease: an emerging health concern?

Nature Reviews Gastroenterology & Hepatology, Published online: 07 April 2026; doi:10.1038/s41575-026-01188-7Concerns have been raised as to whether microplastics and nanoplastics (MNPs) influence human health. This Perspective examines the emerging evidence on MNP accumulation in the liver and its potential effects on human liver health and disease. Research gaps and priorities are also addressed.

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The London Immunity in Health and Disease Symposium

This two day symposium will highlight cutting edge research in immunity in health and disease.

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Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control - Nature Metabolism

The microbial metabolite trimethylamine (TMA), the precursor of TMAO, which is associated with adverse cardiometabolic outcomes, is shown to have beneficial metabolic and anti-inflammatory effects in the host in the context of obesity.

dlvr.it

PhD Projects 2026: QMUL Centre for Predictive in vitro Models

The Centre for Predictive in vitro Models (CPM) represents multidisciplinary research focusing on the development and use of predictive in vitro models at Queen Mary University of London. This incorpo...

cpm.qmul.ac.uk

Architecture of the neutrophil compartment - Nature

Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

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Towards a reference cell atlas of liver diversity over the human lifespan

Nature Reviews Gastroenterology & Hepatology, Published online: 13 October 2025; doi:10.1038/s41575-025-01114-3This Roadmap presents and outlines the creation of the Human Liver Cell Atlas as a reference map and resource for the liver community, providing an overview of the steps needed to build the atlas, as well as outlining the major challenges and potential of this venture.

nature.com

How to apply

Applications for 2026 entry will open on Tuesday 7 October 2025 at midday (BST) and close at 23:59 (GMT), Tuesday 18 November 2025.

imperial.ac.uk

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

imperial.ac.uk

Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment

Nature Reviews Gastroenterology & Hepatology, Published online: 22 September 2025; doi:10.1038/s41575-025-01118-zThis Review provides a comprehensive overview of the role of tissue-resident memory CD8+ T cells in hepatic immune responses, explores their dual function in liver immunoprotection and immunopathology, and discusses their therapeutic potential.

nature.com

Research Technician:Oxford Road

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Group Leader Career Development Fellowships - Dunn School

Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

path.ox.ac.uk

Myeloid cells in chronic liver inflammation - Cellular & Molecular Immunology

Cellular & Molecular Immunology - Myeloid cells in chronic liver inflammation

nature.com

Humoral determinants of checkpoint immunotherapy - Nature

Rapid extracellular antibody profiling reveals a contribution of autoantibodies to the effectiveness of checkpoint immunotherapy for cancer.

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MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences

Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.

lms.mrc.ac.uk

Programme Leader Track - MRC Laboratory of Medical Sciences

We are recruiting Programme Leader Track positions focusing on 1) Metabolic Physiology using murine and/or human in vivo models and 2) Immunometabolism.

lms.mrc.ac.uk

Research Associate in Mucosal Immunology :Manchester

jobs.manchester.ac.uk

MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences

The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...

lms.mrc.ac.uk

Kupffer cell programming by maternal obesity triggers fatty liver disease - Nature

In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

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Kupffer cell programming by maternal obesity triggers fatty liver disease

Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

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Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease

Nature Reviews Gastroenterology & Hepatology, Published online: 22 May 2025; doi:10.1038/s41575-025-01068-6Hepatic stellate cells (HSCs) are best known as the primary fibrogenic liver cell type. This Review provides a comprehensive overview of protective and pathogenic HSC functions in health and disease and discusses novel therapeutic concepts derived from this dual role.

nature.com