¿Qué hace que una placenta pueda alimentar al feto? Un estudio del grupo de Vicente Pérez-García en el CBM descubre un papel clave de la proteína IRS2 en la formación de la placenta, su vascularización y en el crecimiento fetal. www.cbm.uam.es/index.php/20... @csic.es @uam.es

Un estudio revela el papel clave de una proteína en la formación de la placenta y el crecimiento del feto - Centro de Biología Molecular Severo Ochoa

Un equipo del Centro de Biología Molecular Severo Ochoa (CBM), instituto mixto del Consejo Superior de Investigaciones Científicas (CSIC) y la Universidad Autónoma de Madrid (UAM), ha identificado en ...

cbm.uam.es

Investigadores del grupo de Vicente Pérez en el CBM han creado un modelo que reproduce en laboratorio el entorno real de la fecundación. Un avance clave para entender mejor la fertilidad y el desarrollo temprano. www.cbm.uam.es/index.php/20... @csic.es @uam.es

Un modelo experimental en 3D recrea el entorno de la fecundación que podría mejorar las técnicas de reproducción asistida - Centro de Biología Molecular Severo Ochoa

Un equipo liderado desde el Centro de Biología Molecular Severo Ochoa del Consejo Superior de Investigaciones Científicas (CBM-CSIC-UAM) ha desarrollado organoides de oviducto bovino, pequeñas estruct...

cbm.uam.es

🚨🚀 New study out! 🧫 We developed hormonally responsive bovine oviductal organoids producing bioactive fluid 🧬 that enhances sperm capacitation & acrosome reaction 🐄🐄✨🥌🥌 @cbm-csic-uam.bsky.social @cipfvalencia.bsky.social @um.es @csic.es link.springer.com/article/10.1...

🧬 ¿Y si el origen de una complicación grave del embarazo estuviera en los primeros pasos de la placenta? Un estudio del grupo de Vicente Pérez García en el CBM revela un mecanismo genético temprano que podría explicar la preeclampsia precoz. www.cbm.uam.es/index.php/20...

Un mecanismo genético temprano en la formación de la placenta podría explicar una grave complicación del embarazo - Centro de Biología Molecular Severo Ochoa

Un equipo internacional de investigadores liderados desde el Centro de Biología Molecular Severo Ochoa, centro mixto del CSIC y la UAM, ha identificado un mecanismo molecular implicado en la preeclamp...

cbm.uam.es

🤰Un mecanismo genético temprano en la formación de la placenta explicaría una grave complicación del embarazo 🧬Liderado por el @cbm-csic-uam.bsky.social  el trabajo identifica que el desajuste de un gen regulador origina alteraciones como la preeclampsia ➡️http://tiny.cc/yxg1101

#BAP1 overexpression induces early onset #preeclampsia–like features in #placental #organoids: ❌blocked extravillous #trophoblast differentiation ❌impaired syncytialization 🔥persistent pro-inflammatory signatures @cbm-csic-uam.bsky.social @csic.es 👏🥳team! www.nature.com/articles/s41...

🚨🚀 New bioRxiv preprint! 🧫 We developed hormonally responsive bovine oviductal organoids producing bioactive fluid 🧬 that enhances sperm capacitation & acrosome reaction 🐄🐄✨🥌🥌 @cbm-csic-uam.bsky.social @cipfvalencia.bsky.social @um.es

bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · 6mo ago

Hormonally responsive bovine oviductal organoids recapitulate native oviductal secretions and enhance sperm capacitation https://www.biorxiv.org/content/10.64898/2026.03.10.710777v1

Is the placenta in crisis? See our paper in Biological Reviews: “Placental crises: disruptive selection and maternal under-investment as the foundations of mammalian placental evolution and dysfunction” Open access doi.org/10.1002/brv..... Huge credit to @davislaundon.bsky.social who led this work.

Exciting News! 🚀 Registration Open! | Loke CTR Annual Meeting 2026 🎉 📅 16-17 July 2026 📍 St John’s College, Cambridge | 💻 Hybrid conference (in-person & online) 🔬 Epigenetics of embryogenesis and placentation 📌 To find out more and to register www.trophoblast.cam.ac.uk/ctrconferenc...

A human embryo implantation model from the @Rugg-Gunn Lab *key for understanding the early extraembryonic-maternal interactions Congrats to everyone involved! It’s been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors 🥂🍾 www.cell.com/cell/fulltex...

Modeling human embryo implantation in vitro

Building an in vitro model of receptive endometrium allows investigation of human embryo implantation and early post-implantation development and recapitulates the earliest stages in establishing the ...

cell.com

Babraham Institute@babrahaminst.bsky.social · 9mo ago

Learn more about this research in our interview with Peter Rugg-Gunn 🧪 youtu.be/2NYsWPp1UYk?...

Very excited to finally share this work! 🥳🎊🎉Huge thanks to my former colleagues, the collaborators and @grazianomartello.bsky.social. See the post below for more info:

Graziano Martello@grazianomartello.bsky.social · 9mo ago

🚨 New paper out! A human epiblast model reveals how dynamic TGF‑β signalling controls epithelial identity in early mammalian development Here is the full paper: rdcu.be/eSWEs 🧵 A twittorial: THREAD

En estos días celebramos las 40 Jornadas Científicas del CBM. Renovadas en el año de nuestro cincuentenario, 50 de nuestros IPs presentarán su investigación en charlas y pósters a lo largo de dos días. Estupenda oportunidad de interacción multidisciplinar. www.cbm.uam.es/index.php/ev...

40th CBM Science Meeting - Centro de Biología Molecular Severo Ochoa

Annual Science Meeting

cbm.uam.es

CDKL5 Deficiency Disorder (CDD) leads to seizures & intellectual disability. This study shows that #Chlamydomonas CDKL5 kinase is activated by the LF2/CDK20 kinase; CDKL5 in turn regulates #intraflagellar transport via protein abundance & phosphorylation #cilia @plosbiology.org 🧪 plos.io/45490eP

Earlybird deadline extended 🚨Join us at the Frontiers in Stem Cell Innovation (FISCI) Conference on the 5th –6th February 2026 in Cambridge. Up to 50% off ends 16th January: www.eventbrite.co.uk/e/frontiers-...

Frontiers in Stem Cell Innovation 2026

Join leading academics and industry professionals exploring cutting-edge stem cell technologies and disease modelling for drug discovery

eventbrite.co.uk

🚨Preprint! #Placental #organoids developing #preeclampsia (PE)?🤯Boosting #BAP1 induced key traits of early-onset PE: ❌impaired syncytialization & EVT differentiation 🔥persistent pro-inflammatory signals 🤒broad placental dysfunction 🚀🥦🎉team! @cbm-csic-uam.bsky.social www.biorxiv.org/content/10.1...

BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia

Preeclampsia, a life-threatening hypertensive disorder of pregnancy, is a leading cause of maternal and perinatal morbidity and mortality. Its early-onset form (EO-PE), requiring delivery before 34 we...

biorxiv.org

🚨 New preprint! We built a single-cell atlas of 14 multilayered epithelia and revealed a conserved transcriptomic program guiding tissue architecture and fate composition. Our work brings decades of tissue-specific studies together into a unified evo-devo framework. www.biorxiv.org/content/10.1...

· #AcademicSky · The European Research Council is launching €7m Plus Grants for ambitious, long‑term research — open to researchers at any career stage but limited to about 30 awards; current ERC grantees and applicants are ineligible, reports @clanicholson.bsky.social.

ERC’s new €7m Plus Grants open to researchers at any career stage - Research Professional News

European Research Council president describes scheme as part attempt to lure US talent

researchprofessionalnews.com

🧬 PhD Position: Evolutionary & Comparative Genomics 🕷️ Join us at @uni-goettingen.de for a 3-year PhD (65% TV-L E13). We will investigate the genomic & phenotypic impact of gene duplication across 233 arthropod genomes! More infos 👇 and s.gwdg.de/eDrAAY #Evolution #Genomics #Bioinformatics

Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction | New England Journal of Medicine www.nejm.org/doi/full/10....

Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction | NEJM

The benefit of beta-blockers after myocardial infarction in patients with a preserved left ventricular ejection fraction (LVEF) is unclear. We conducted a meta-analysis at the individual-patient le...

nejm.org

Looking to pursue cutting-edge research in early development, maternal-fetal interaction, or placental biology? See 👇 - Funded PhD www.trophoblast.cam.ac.uk/phd-students... - Next Generation Fellowship www.trophoblast.cam.ac.uk/next-generat... - MPhil www.mphil.bio.cam.ac.uk/mphil-pathwa...

2 weeks left to apply! Fully-funded 4-year PhD studentships for home or overseas students, applications open till 4 November. 🔗 Please like and share to spread the word! www.trophoblast.cam.ac.uk/phd-students... Take a look at projects for 2025/26 www.trophoblast.cam.ac.uk/opportunitie...

Very happy to share I've written a review on placental vascular formation in mice and humans, now published in @dev-journal.bsky.social. journals.biologists.com/dev/article/... @idrm.ox.ac.uk Funded by the @thebhf.bsky.social

Feto-placental blood vessel development

Summary: This Review contains an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field.

journals.biologists.com

✳️ Join us for this week's interesting #CiMUSSeminar with guest speaker @vpglab.bsky.social from @cbm-csic-uam.bsky.social. Dr. Vicente Pérez explores novel therapies for pregnancy disorders & cancer Hosted by PI @mobilegenomes.bsky.social mes.bsky.social #RedeCIGUS #FondosEuropeos @usc.gal

Using #CRISPR/Cas9 to genetically modify cells to produce extracellular matrices with altered compositions. elifesciences.org/reviewed-pre...

Check out these feather buds on the chicken embryo's wing! Our latest study @plosbiology.org reveals that temporary inhibition of sonic hedgehog signalling transforms feathers into simple, protofeather-like structures—similar to those of their dinosaur ancestors🔬🦖🧪 journals.plos.org/plosbiology/...

A study in Nature Communications shows that Zika virus NS1 induces tunneling nanotubes in placental cells, which facilitate viral spread and transport of mitochondria in placental cells. The findings could be used to develop therapeutic strategies targeted against this transmission mode. 🧪

Zika virus NS1 drives tunneling nanotube formation for mitochondrial transfer and stealth transmission in trophoblasts - Nature Communications

Michita et al. show that Zika virus (ZIKV) NS1 induces tunneling nanotubes (TNTs) in placental cells, which facilitate viral spread and transport of mitochondria in placental cells. Infection with a NS1 mutant ZIKV not inducing TNTs results in a higher interferon response than wild-type ZIKV infection.

go.nature.com

Our new paper linking Tregs, uNK cells & uterine vasculature “Treg cells promote decidual vascular remodeling and modulate uterine NK cells in pregnant mice” super effort from Alison Care, Shanna Hosking, Lachlan Moldenhauer and all the team! insight.jci.org/articles/vie...

www.cbm.uam.es/index.php/20...

Descifran un mecanismo clave para el desarrollo de la placenta, basado en la metilación del ADN placentario - Centro de Biología Molecular Severo Ochoa

La expresión de los genes es el proceso mediante el cual la información contenida en el material genético se utiliza para producir proteínas, que a su vez realizan una función […]

cbm.uam.es

Applications are open for our Caregiver Travel Grant 2025! Apply now for a chance to receive flexible funding to cover caregiving expenses while attending an in-person scientific conference! Apply: www.mothersinscience.com/caregiver-tr... 📅 Deadline: March 31, 2025 #WomenInSTEM #STEMM #AcademicMama

Excited to share our most recent work in Cell Stem Cell, led by @georgiaplea.bsky.social, characterising determinants of DNA methylation patterning in human trophoblast stem cells! A great collaboration with @vpglab.bsky.social. tinyurl.com/93mchcd2 @loke-ctr.bsky.social @cam-repro.bsky.social

Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome

The placental DNA methylation landscape is unique, with widespread partially methylated domains (PMDs). The placental “methylome” is conserved across …

tinyurl.com