Woo. The big day is finally here. @jmarlesw.bsky.social kicking off the Northern Eye Opening Symposium

Looking forward to the Grand Opening of the Northern Eye Imaging facility on 5th November at the Frederick Douglass Centre, Newcastle. Register now nusbf.ncl.ac.uk/ccpem-tfs-ne... for the latest #structuralbiology and #cryoem in the region, to see the new Tundra cryo-TEM and lots more!

Please join us in the North East on the 5th of November as we celebrate with a one day symposium for the launch of our BBSRC funded 100 keV Tundra TEM aka the Northern Eye: nusbf.ncl.ac.uk/ccpem-tfs-ne... The symposium has been kindly sponsored by @thermofishersci.bsky.social & @ccpem.bsky.social

The CCP4 Northern Structural Biology Meeting is back again in Newcastle 6-7th November 2025. If you are a structural biologist/biochemist in the North of the UK please register and submit abstracts by this Friday 17th. nusbf.ncl.ac.uk/ccp4-norther...

Dorothy Crowfoot Hodgkin, biochemist & trailblazer in crystallography, she established the biomolecular structures of insulin, vitamin B12, & penicillin winning the Nobel in Chemistry in 1964 #WomensHistoryMonth #WomenInStem #WomenInScience

Nikol Zografou Barredo, PhD Student (Medicinal Chemistry), Newcastle University #facesofscience #chemsky #sciencesky

What better way to join Bluesky than post our first professional team photo. We've been busy onboarding everyone over the last few months, so welcome to Giusy, Debakshi, Kako and Gonzalo who have joined James. We're looking forward to helping our users do great cryo-EM.

Here we unexpectedly find that the ribosomal protein S20/L26—identified at the dawn of ribosome research but later deemed a biochemical artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation is here: www.nature.com/articles/s41...

Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells - Nature Communications

Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...

nature.com

New cryo-EM/ET story - a brilliant collaboration with Sergey Melnikov's lab in Newcastle @sergeymelnikov.bsky.social and Stefan Pfeffer's lab in Heidelberg @pfeffercryolab.bsky.social. Great work in particular by Karla Helena-Bueno and @sophiekopetschke.bsky.social www.nature.com/articles/s41...

Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells - Nature Communications

Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...

nature.com

We are thrilled to announce the 2025 EMBO practical course in cryo-em image processing, Birkbeck College, London, 9-16 Sept 2025. More info & apply: meetings.embo.org/event/25-cry... Organisers Giulia Zanetti & Helen Saibil. Beautiful image from co-organizer @carolynmoores1.bsky.social lab.

Image processing for cryo-electron microscopy

Cryo electron microscopy (cryo EM) is a major structural biology method for studying macromolecular complexes and cellular structures in their native states. Stable high resolution cryo microscopes, …

meetings.embo.org

**deadline Mar 30th** Passionate about #cryoEM? Interested in #PhD project on allosteric mechanism of a dynamic enzyme implicated in metabolic and neurological disorders? Join @allostericstate.bsky.social and me in NCL on a funded @mosmedcdt.bsky.social studentship. www.findaphd.com/phds/project...

🎉 Today we're celebrating as 12 of our subjects have been ranked within the world's top 100 in the latest QS World University Rankings by Subject. Congratulations to all our colleagues and teams involved in this fantastic achievement👏 #WeAreNCL #QS

"CACHE Challenge 2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13" is out now on ChemRxiv: dx.doi.org/10.26434/che... You can find a discussion of our workflow and designed compound in the preprint (WF1438), which was among 13 compounds confirmed to bind to Nsp13.

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13

A critical assessment of computational hit finding experiments (CACHE) challenge was conducted to predict ligands for the SARS-CoV-2 Nsp13 helicase RNA binding site, a highly conserved COVID-19 target...

dx.doi.org

**Please repost**Interested in a #PhD project on #cryoEM & enzymatic mechanism? Join @allostericstate.bsky.social and me in Newcastle on a funded @mosmedcdt.bsky.social studentship. Choose project code mos2_04 in Thomas' link below. Or go to: www.findaphd.com/phds/project...

TJ McCorvie@allostericstate.bsky.social · 2y ago

PhD opportunity at @newcastleuni.bsky.social 🚨 Are you passionate about structural biology & enzymes? We have a fully funded @mosmedcdt.bsky.social PhD project with KinderSpital Zürich on studying the allosteric inhibition of human MTHFR. research.ncl.ac.uk/mosmed/joinu... #CryoEM #structuralbiology

A story of fragment screening to initiate drug discovery

The Institute of Cancer Research@icr.ac.uk · 2y ago

📰 Prof Paul Workman, our former CEO, along with his team in our Centre for Cancer Drug Discovery, have made a breakthrough that could lead to new drugs for #chordoma — a rare #BoneCancer that led to the death of his mother. Read more in @theguardian.com ⤵️ www.theguardian.com/science/2025...

Very interesting to see the 50 new drugs that made it to FDA approval in 2024 in one place. A lot of really exciting small molecule chemistry with interesting functional groups, deuterations and covalent warheads. #chemsky #chembio www.linkedin.com/posts/chrisd...

Chris De Savi on LinkedIn: #medicine #pharmaceuticals #healthcare | 90 comments

FDA Novel Drug Approvals 2024 #medicine That is a wrap for 2024! And another year of relentless drug discovery! There you have it, drug-hunting aficionados,… | 90 comments on LinkedIn

linkedin.com

Registration for the CCP-EM Spring Symposium 23-25th April 2025 open, see www.ccpem.ac.uk/training/spr...

Great discovery of a new gene involvement in vitamin B6 metabolism

Izabella A. Pena, PhD 🇧🇷🇨🇦 @izabellapena.bsky.social · 2y ago

Here is a quick thread to promote my research! After years of dedicated research, I'm thrilled to share our article just published at Nature Communications :) www.nature.com/articles/s41... #metabolism #CRISPRscreens #mitochondria

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X https://go.nature.com/42tH8Ai

Bluesky’s science takeover: 70% of Nature poll respondents use platform

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.

go.nature.com

Anyone ever have any problems with bacmid transpositions continuously not working? I have been struggling to get any positive white colonies using pFastbac plasmids from Twist and even for a plasmid from another lab for a while now.

You want to build an apparatus for time-resolved cryo-EM? Easy: bio-protocol.org/en/bpdetail?...

A blue sky day for my bluesky acct www.reddit.com/r/NewcastleU...

From the NewcastleUponTyne community on Reddit: Blue Sky Day

Explore this post and more from the NewcastleUponTyne community

reddit.com

Time to look up your favourite (human) protein in the subcellular map.

Marco Hein@marco.heinlab.org · 2y ago

Time to share our organelle proteome paper out in @cellcellpress.bsky.social: doi.org/nzwz We created a spatial map of human cells using organelle immunoprecipitation at scale. Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/ 1/3 🧪

Finally updated the lab website: www.medicinesfromthesea.com

Duncan lab

Duncan lab

medicinesfromthesea.com

Diagnose the diagnosable and don't miss the treatable. Did you know that approximately 1 in 5 IMDs (18%) are amenable to some form of treatment? Therefore it's imperative to make the diagnosis and keep abreast of developments in the therapy space. onlinelibrary.wiley.com/doi/full/10....

Every point so true. I go further to memorise the first 2-3 lines of every slide so I feel I'm in control of the storytelling and the flow

Itai Yanai@itaiyanai.bsky.social · 2y ago

Knowing how to give a good talk is a crucial skill to have, but it's mostly not formally taught very well. Here's my strategy for how to prepare for the presentation, actually present it, and then answer the questions.

Let's make 2025 the "Year of the Mitochondria," to stimulate more research for mitochondrial and other diseases, incite curiosity and commitment from funders to invest in mitochondria as the heart of health and a key to solving resistant diseases and conditions. @MitoWorld.org / Image: Rehman Lab

This has been published for a while but thought it a neat workflow to study metabolic enzyme filaments in cells www.cell.com/cell/fulltex...

FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis

Microorganisms facing adverse conditions for growth and reproduction adjust the function of metabolic enzymes by regulating enzyme self-assembly into filaments. The multiscale filament identification workflow determines polymer composition in the cellular context, enabling the exploration of physiological filament function.

cell.com

In case you missed it on the other site, we've written up some of our experiences from the CACHE2 hit finding challenge in this blog: cole-group.github.io/2024/09/10/c... Thanks to the organisers for a well-run challenge! @creechem.bsky.social @bieniekmat.bsky.social @nataliejtatum.bsky.social

Conscience@conscience-network.bsky.social · 2y ago

CACHE Challenge #2 identified seven ‘hits’ for pan-coronavirus treatment: conscience.ca/news/cache-c...

Dear world: this is what a graphical abstract is supposed to look like.

Pauline Franz@paulinefranz.bsky.social · 2y ago

What a great conclusion to my final days at EPFL: our 🔥article is highlighted on the @angewandtechemie.bsky.social Frontispiece!! ▶️ tinyurl.com/mvtecrsz @beatfierz.bsky.social #chemicalbiology #clickchemistry #DNArepair #SciArt🐡 🧪