Extremely happy to see that my latest work on understanding how ARISC-RAP80 recognises and cleaves ubiquitin chains is now published @natcomms.nature.com Check it out if you are interested in #DUBs, #DNA repair, or #cryo-EM: www.nature.com/articles/s41...

Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex - Nature Communications

How the BRCA1-A complex finds and removes ubiquitin signals at DNA breaks remains unknown. Here the authors show that ARISC–RAP80 binds K63-linked ubiquitin chains through multiple subunits and non-ca...

nature.com

🚨 👇 Come and join us in York as a new lecturer (assistant professor) in cryo-ET! This is a research and teaching appointment to the York Structural Biology Laboratory (YSBL). From personal experience it's a fantastic place to start a group. Please share widely! jobs.york.ac.uk/vacancy/lect...

Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...

Great discussion and update on @guruspod.bsky.social with @kgandersen.bsky.social, Eddie Holmes, Mike Worobey on the weaponisation of the origin SARS CoV-2. Frustrating as fuck that they still need to do this in 2026! podcasts.apple.com/gb/podcast/d...

Lab Leak Groundhog Day: COVID Origins in 2026 with Worobey, Andersen, and Holmes

Podcast Episode · Decoding the Gurus · 10 August · 1hr 45min

podcasts.apple.com

Over-the-moon that our structural #cryo-em work on the #drebrin #F-actin interaction has now been published in full at #NatureCommunications. Congratulations to Weilong, Lee-Ya and the rest of the team in London and Hamburg who worked on this :) www.nature.com/articles/s41...

Structural mechanisms of drebrin-mediated F-actin network modulation - Nature Communications

Drebrin regulates crucial cellular processes through its F-actin binding and regulating functions. Here, the authors report cryo-EM structures of drebrin’s actin-binding domains complexed with F-actin...

nature.com

Structural and functional characterisation of the dextran utilisome from Bacteroides thetaiotaomicron pubmed.ncbi.nlm.nih.gov/42569704/ #cryoEM

We've been seeing a lot of "in situ" lately in titles from fancy journals (not pointing any fingers 👀). I’ve delayed posting this, but as more and more come out, I'm afraid "in situ" is becoming an empty buzzword, much like "near-atomic" was for SPA 🔬 1/n #cryo-ET #cryo-EM #cryoET #cryoEM 🧪

One month left to apply!! 🧪 @biozentrum.unibas.ch seeks a group👩‍🔬 exploring molecular questions relevant to climate 🌍, including biogeochemical cycles (e.g., carbon, nitrogen) ♻️, bioenergetic energy conversion (e.g., photosynthesis, chemosynthesis) ☀️⚗️, and the adaptation to environmental change 🌊🌡️🦠🌾

Ben Engel@cellarchlab.com · last mo.

Super excited to launch this search for a new endowed professor at the @biozentrum.unibas.ch! Join us to build a research cluster in Climate Biophysics! 🌍🌊🌾🔬🧪 This is a unique opportunity to create a community in Basel🇨🇭working together on this timely topic! ⏳🌡️ Questions? Please reach out! 👩‍🔬👨‍🔬

Join the 9th Austrian CRYO-EM Symposium at Vienna BioCenter on September 24-25! Register before Sep. 1st (Abstract deadline is Aug. 5th!): www.imp.ac.at/research/cry...

Heading to #IUCr2026 in Calgary, 11-18 Aug? At booth #29 we're sharing how we’re bringing more #cryoEM to more spaces. And don't miss our Lunchtime Symposium with an expert panel answering your questions Thu, 13 August, 13:00, Champions C suite. Register: ter.li/9lf78lq5 #StructuralBiology

According to the parliamentary annual report & accounts for the 2025/26 financial year, the cost of subsidising the bars in the House of Commons alone was around £5.8 million. Meanwhile, to save £3 million less than that, Jodrell Bank is being defunded and shut down. share.google/MRHIvCsCsKoc...

Jodrell Bank's Lovell telescope faces axe in science cuts, BBC understands

Astronomers warn it would tear the heart out of UK science, and leave a generation untrained.

share.google

Research Associate (structure and function of large histone deacetylase containing repression complexes) Prof. John Schwabe, University of Leicester - Molecular and Cell Biology, experience of Cryo-EM, NMR and Crystallography www.jobs.ac.uk/job/DSL479/r... #NMRjobs #NMRchat #NMR 🧲

Research Associate at University of Leicester

Explore an exciting academic career as a Research Associate. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

jobs.ac.uk

Closing this weekend! Join us as a scientific biocurator in the OneDep biocuration team. Work with structural data, software and processes that support data deposition and curation. Apply by 2nd Aug: tinyurl.com/47t93kxp. CAK-CDK1-Cyclin-B1: Timing is everything (#cryoEM EMD-54971).

One month left to apply (deadline August 31st)! 👇 #Virology #AcademicJobs #FacultyJobs #FacultyPosition #TenureTrack #GroupLeader

Daniel Hurdiss@danielhurdiss.bsky.social · last mo.

We are looking for an Assistant or Associate Professor to join us at the @utrechtvirology.bsky.social. Interested in building an independent research programme in a collaborative #virology environment? Please take a look and share with anyone who might be a good fit! www.uu.nl/en/organisat...

Pacha's Just Right Meme

ALT: Pacha's Just Right Meme

static.klipy.com

bioRxiv Biochemistry@biorxiv-biochem.bsky.social · 2w ago

Recovery of a minor cryo-EM particle population reveals conformational equilibria linking cofactor loading, turnover, and reactivation in methionine synthase https://www.biorxiv.org/content/10.64898/2026.07.27.741092v1

BRCA2 and RAD54B FxPP motifs Bind DMC1 Filaments through Persistent and Transient Interfaces www.biorxiv.org/content/10.64898/2026.07.24.740592v1 #cryoEM

An almost unbelieveable predicament. A country in retreat?

Nature@nature.com · 2w ago

Can commercial funding fill a hole of £42 million a year in the finances of some of the United Kingdom’s flagship science laboratories and facilities? go.nature.com/4bcxRjL

Dynamic dimer-of-dimers architecture defines Mg2+ transport in human CNNM4 pubmed.ncbi.nlm.nih.gov/42497866/ #cryoEM

We are hosting candidates to apply for a PhD position with a full salary at University of Helsinki. This will be a co-supervised project with the group of Alexander Mühleip to study function, structures and draggability of ER protein translocation in different parasitic organisms.

RESDOC Project – Training Doctoral Excellence for Resilient and Just Future | University of Helsinki

RESDOC (Resilient and Just Systems Doctoral Project) is an international doctoral training project at the University of Helsinki in Finland. It brings together interdisciplinary and cross-sectoral res...

helsinki.fi

Happy that our most recent paper on nucleotide excision repair mechanisms has now been published in Science Advances. This project was led by @natalia-mg.bsky.social and @callumhaste.bsky.social and focused on visualising early steps of the NER process by #cryoEM. www.science.org/doi/10.1126/...

Visualization of stepwise derepression of TFIIH in global genome nucleotide excision repair

Cryogenic electron microscopy captures nucleotide excision repair complexes assembling on damaged DNA templates.

science.org

🚀 Can automation solve preferred orientation in your #cryoEM datasets? After automating processing across 21 GPCR datasets in #CryoSPARC, we updated the workflow to be even more robust to preferred orientation, achieving improved map quality over manual processing. Read more 👉 bit.ly/3RyOIGG

Job alert: Viruses (#cryoEM EMD-24741), chaperones, molecular assemblies, enzymes, drug targets and more. Structures tell stories. Join the EMDB and OneDep biocuration team at EMBL-EBI and help scientists tell theirs. Apply by 2nd Aug: tinyurl.com/47t93kxp

We currently have an opening for a PhD position in the lab. If you are interested in pursuing some serious structural biology of photosynthetic and chloroplast processes please apply. Prerequisite is previous experience in cryoEM and/or phototrophs. stellenangebote.uni-marburg.de/jobposting/2...

Today I'm posting a blog about another ridiculous antibody blunder. Dozens of papers in the senescence and ageing field have mistakenly used an antibody for E. coli β-galactosidase when trying to stain for the human protein with the same name. forbetterscience.com/2026/07/21/d...

Job alert: Protein chaperones ensure proteins fold correctly (#cryoEM EMD-23004). Biocurators ensure structural biology data are accurate and reusable. Join the EMDB and OneDep biocurators to maintain the integrity of structural biology data. Apply by 2nd Aug: tinyurl.com/47t93kxp

I got our tickets. #jimothy #imax

King’s College London is hiring a Facility Manager to lead their new Cryo-EM Structural Discovery Facility... and more! 🔬🏛️ 🗓 Apply by 23 July 2026: https://f.mtr.cool/icjergnngx #CryoEM #CoreFacilities #ResearchJobs @kingscollegelondon.bsky.social

Cryo-EM Facility Manager | King's College London

f.mtr.cool

Some progression on 58 kDa GBA as part of my work with @recon4imd.bsky.social. Combined tilted data (Glacios) with careful processing gives a ~4.0 Å map with clear secondary structure features. Still not the resolution that I need for variant studies but a step in the right direction! #CryoEM

1/5: Our latest preprint is out! We show that LEA proteins can diversify particle orientations in cryo-EM, helping to overcome preferred orientation at the air-water interface (AWI). www.biorxiv.org/cgi/content/... with @cijilim.bsky.social and Tim Grant #CryoEM #LEAproteins

Diversifying particle-orientation distributions in cryo-EM with LEA protein additives

Preferential orientation at the air-water interface (AWI) remains a persistent challenge in cryo-electron microscopy, often requiring extensive optimization or specialized grid preparation strategies....

biorxiv.org

🚨 FINAL CALL - just 4 days left to apply for an in-person place on the Wellcome–MRC in situ Cryo-ET Workshop 2026. 📅 28 Sept – 02 Oct 2026 📍 @diamondlightsource.bsky.social & @astburycentre.bsky.social 💻 Hybrid stream available ⏰ In-person application deadline 19 July 🔗 shorturl.at/LRihg