Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution - Nature Metabolism

In this Review, the authors present a roadmap towards achieving consensus on development, analysis and interpretation of single-cell transcriptomics data in adipose tissue, including discussion of roadblocks, best practices and ideal cell-type markers for annotation of adipose tissue cell types in mice and humans.

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Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle

Objective: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical mod...

biorxiv.org

From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research - Nature Metabolism

Non-alcoholic liver disease (NAFLD) is now metabolic dysfunction-associated steatotic liver disease (MASLD), emphasizing the key metabolic factors of obesity, insulin resistance, vascular dysfunction and dyslipidaemia. Here, we discuss impacts on the existing body of clinical and preclinical liver disease research and on research moving forward.

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Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827

The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.

science.org

A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia - Nature

In mammals, the enzyme TGDS produces UDP-4-keto-6-deoxyglucose, which binds to the catalytic pocket of UDP-xylose synthase, thereby regenerating the essential NAD+ cofactor of UDP-xylose synthase...

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Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity | Journal of Cell Biology | Rockefeller University Press

Posttranslational modifications play a crucial role in regulating autophagy and lysosome–related transcription factor TFEB. Huang et al. find the increase

rupress.org

mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal

imageimageDuring starvation, individual amino acid levels are thought to be relayed via distinct metabolic sensors, but how mTORC1 senses glutamine remains unclear. This study finds that GCN2 kinase a...

embopress.org

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells

Nature Metabolism, Published online: 14 July 2025; doi:10.1038/s42255-025-01325-7Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

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Glycogen metabolism: not just a one-trick pony - Nature Reviews Endocrinology

Nature Reviews Endocrinology - Glycogen metabolism: not just a one-trick pony

nature.com

Unraveling Skeletal Muscle Insulin Resistance: Molecular Mechanisms and the Restorative Role of Exercise | Circulation Research

Skeletal muscle is essential for movement and maintaining energy homeostasis and is the primary tissue for insulin-stimulated glucose uptake. Skeletal muscle is composed of various cell types that hel...

ahajournals.org

Targeting cardiometabolic risk in type 1 diabetes through incretin physiology

People living with type 1 diabetes have significantly increased cardiovascular risk compared with the general population. Traditional risk factors include hypertension, dyslipidaemia, and obesity. How...

cell.com

Fuelling synapses via lipid metabolism

Nature Metabolism, Published online: 01 July 2025; doi:10.1038/s42255-025-01306-wSynapses have long been thought to rely exclusively on glucose metabolism for energy. In this issue of Nature Metabolism, Kumar et al. reveal that synapses can tap into fatty acid metabolism to fuel ATP production and maintain synaptic activity when glucose is limited.

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Sustained Weight Loss With Combined LEAP2 and Semaglutide Treatment in Mice

The recent identification of liver-expressed antimicrobial peptide 2 (LEAP2) as an endogenous antagonist and inverse agonist of the growth hormone secretag

diabetesjournals.org

Altered Relaxation and Mitochondria‐Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise

Slowed relaxation and altered MERCs embody early stages of aging in muscle, and are prevented by regular exercise.

onlinelibrary.wiley.com

Protagonist Enters Obesity Fray With Triple-G Pill, Eyeing 2026 Clinical Start

With PN-477, Protagonist is directly going up against Eli Lilly, which is advancing retatrutide, also a triple-G agonist, in a Phase II trial.

biospace.com

The Use of Salt-Inducible Kinases (SIKs) Inhibitors as an Emerging Treatment for Inflammatory, Allergic, Autoimmune, Cancer, and Metabolic Diseases - PubMed

The invention in this patent application relates to pyrazolo-[1,5-<i>a</i>]-pyridine derivatives represented herein as formula I and formula II. These compounds are highly active SIK inhibitors and ma...

pubmed.ncbi.nlm.nih.gov

Sticky membranes of dead red blood cells obstruct small vessels

Damage to the vascular lining leads to interactions with red blood cells that hint at how to treat dangerous complications of heart attack, stroke and COVID-19.

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Unravelling cysteine-deficiency-associated rapid weight loss - Nature

Conditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress responses, and by unexpectedly depleting coenzyme A, leading to metabolic inefficiency.

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