Delighted to announce the posting of our latest preprint, which links stress-induced relocalisation of multiple organelles by dynein to adaptive changes in gene expression in the nucleus (1/n) 🧵 www.biorxiv.org/content/10.6...

Happy to share our latest contribution! How do endosomes get their shape? Well, we show a new role for Arp2/3 in shaping organelles and traffic in fission yeast. New tricks for an old dog!

Sophie G Martin@sophiemartinlab.bsky.social · 5mo ago

Arp2/3-dependent actin assembly shapes endosomes and promotes intracellular trafficking in fission yeast The work from Alejandro Melero @ameleroc.bsky.social and Miguel Basante-Bedoya just out in Current Biology. www.sciencedirect.com/science/arti... @biology-unige.bsky.social

Extremely grateful to @hfspo.bsky.social and super excited to set this project in motion together with the incredibly talented @ritamateus.bsky.social and @vmonje.bsky.social Zebrafish hide a secret: lipid membranes shaping the crystals behind their stunning structural colors. How? Stay tuned! #HFSP

Human Frontier Science Program@hfspo.bsky.social · last yr.

🥳Congratulations to the 104 pioneering scientists from 30 nations awarded 2025 #HFSPResearchGrants! 🎉Your frontier research is shaping the future of #LifeSciences! 🌍🔬🧪 🏆 Meet the awardees & their projects: www.hfsp.org/bookletRG202... #ScienceDiplomacy #HFSP #FrontierScience #sts

Next, work from the Etienne Herzog, @davip-bdx.bsky.social and @fronzeslab.bsky.social using cryo-CLEM and cryo-ET of cortico-striatal dopaminergic synaptosomes to delineate the architecture of non-synaptic modulation: www.biorxiv.org/content/10.1...

This goes beyond my wildest imaginations! Congratulations to @mathilda95.bsky.social @nadlerlab.bsky.social and all the authors! Such a big step forward for membrane biology.

André Nadler@nadlerlab.bsky.social · 2y ago

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that. www.biorxiv.org/content/10.1...

Looking for a PostDoc? Exciting science and great city! Join us @albertpol.bsky.social @albertherms.bsky.social in @idibaps.bsky.social Barcelona to work in an @ercresearch.bsky.social funded project to study how lipid droplets attract and kill bacteria. www.clinicbarcelona.org/uploads/medi...

Check it out, is finally out!!

The EMBO Journal@embojournal.org · 2y ago

How does tRNA-modifier #Elongator stabilize microtubules during asymmetric cell division? Vicente Planelles Herrero @deriverylab.bsky.social et al find subcomplexes binding to microtubule ends & tubulin dimers, & enriching microtubules with polyglutamylated tubulin www.embopress.org/doi/full/10....

Exciting news! #MembraneTrafficking online seminars with @felixmendu.bsky.social @franbottanelli.bsky.social and me are back! Check the spectacular Jan-April 2025 lineup. Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...

Time to share our organelle proteome paper out in @cellcellpress.bsky.social: doi.org/nzwz We created a spatial map of human cells using organelle immunoprecipitation at scale. Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/ 1/3 🧪

Any #SpatialTranscriptomics people out there interested in studying #microglial development? We need a collaborator based in the Americas or Asia to apply for a #HSPF grant www.hfsp.org/funding/hfsp...

"A study of federally funded research projects in the United States estimated that principal investigators spend on average about 45% of their time on administrative activities related to applying for and managing projects rather than conducting active research" www.pnas.org/doi/10.1073/...

Happy to share our Perspective on #microglia #pruning and help to answer the questions of whether they are hunters or gatherers of brain #synapses 🧠🧪 #neuroskyence nature.com/articles/s4159…

Postdoc position available in the Röper lab at the University of Cambridge @PDN_Cambridge! Join us and discover the role that control of cytoskeletal dynamics, crosstalk and cell adhesion play in the formation of the nephron tube in human renal organoids! jobs.cam.ac.uk/job/48947/

Kicking off here with some old but gold movies showing ER-lysosome interactions triggered by blue-light excitation of the light-sensitive protein eMags. A shining example of how light can control cellular dynamics! 💡🧫✨

Stunning paper by Anne Simonsen's lab, identifying BEACH domain-containing proteins as membrane coat proteins involved in endosomal sorting: rupress.org/jcb/article-... Read also @franbottanelli.bsky.social's beauty on ARF1 directing cargo maturation into RE!(www.nature.com/articles/s41...)

A fun journey of full-length EGFR with Dan Leahy and @edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below: Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...

Latest paper from our lab out now! #TeamTomo #CryoET www.nature.com/articles/s41...

Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes - Nature Structural & Molecular Biology

The authors reconstituted coat protein complex II vesicles from native membranes and used cryo-electron tomography and subtomogram averaging to reveal the arrangement of inner and outer coat layers on...

nature.com

- Imaging interorganelle contacts at a glance - Reviews on machine learning, synchrotron X-ray imaging, fluorescence polarisation microscopy and imaging cell-cell junctions - An Editorial from FocalPlane journals.biologists.com/jcs/issue/13...

Characterizing heterogeneity in amyloid formation processes pubmed.ncbi.nlm.nih.gov/39566372/

Finally this cool story by @brfalcon.bsky.social is out! 😍😍

Michael Ward@michael-e-ward.bsky.social · 2y ago

www.nature.com/articles/s41...

My latest paper, deep proteomic analysis of mouse and human microglia: www.cell.com/cell-reports...

Deep proteomic analysis of microglia reveals fundamental biological differences between model systems

Lloyd et al. generated a comprehensive microglia proteome database, identifying over 11,000 proteins. Fundamental differences between ex vivo and in vitro microglia associated with protein synthesis, ...

cell.com

How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography www.biorxiv.org/content/10.1...