830 wildfires burning across Canada right now. And you know what’s going to make it worse in the future? More oil pipelines. This is why our voice and our vote matters.
Todd Douglas
@apoptoddic.bsky.social
• scientific associate studying why & how cells die • princess margaret cancer centre • he/him https://orcid.org/0000-0002-6053-9345
Thanks to Boyi Gan's group (@mdanderson.bsky.social) for this nice summary and contextualization of our (@craigmcrews.bsky.social) recent paper! Still lots more to understand... www.nature.com/articles/s41...
Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation - Cell Death & Differentiation
Cell Death & Differentiation - Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation
nature.com
Thanks to Boyi Gan's group (@mdanderson.bsky.social) for this nice summary and contextualization of our (@craigmcrews.bsky.social) recent paper! Still lots more to understand... www.nature.com/articles/s41...
Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation - Cell Death & Differentiation
Cell Death & Differentiation - Ribosome stress meets disulfidptosis: HOIL-1 safeguards cell fate during nutrient deprivation
nature.com
Add your name to tell Prime Minister Carney to protect our future over Big Oil profits: www.ourcommons.ca/petitions/en...
Leah ProudLakota (she/her)@leahgazan.bsky.social · last mo.Yesterday's pipeline announcement is yet another reminder that Prime Minister Carney cares more about lining the pockets of his corporate friends than upholding the Constitutional rights of Indigenous peoples and protecting the public from the escalating climate emergency. (1/6)
Today’s announcement shows what this federal government will protect above all else: the profits of Big Oil. Read my full statement on the oil pipeline proposal from the Prime Minister and Premier Smith: www.ndp.ca/news/ndp-rea...
NDP Reaction to West Coast Pipeline Announcement
NDP Leader Avi Lewis shared the following statement in response to the oil pipeline proposal from Alberta Premier Danielle Smith:
ndp.ca
Elon Musk's incitement of pogroms in Belfast reveals he'll use his immense wealth and influence to foment untold fascist violence in the future. Only a global movement can break his power. New piece from @polphilpod.bsky.social and me. Threading highlights below. 1/ newrepublic.com/article/2119...
Elon Musk’s Race War Just Took Darker Turn—Time for a Global Response
The violent fascist riots in Belfast reveal the future that the trillionaire really wants. We need an international movement to constrain him.
newrepublic.com
I NEED YOUR ATTENTION. When violent and controlling people start to feel their power slip, they become more violent and controlling. I believe this is what’s happening in the Administration, now. This is a CRITICAL INFLECTION POINT: we MUST come together and push back *hard* NOW. 🧵 a thread
Scientists: Your voice is needed. New federal regulations could reshape research funding, publishing, and collaboration. Comments close July 13. https://www.ascb.org/science-policy/proposed-regulations-would-fundamentally-change-american-science/
Listen, the @standupforscience.net national team is working all hours of the day to stop Vought, RFK Jr., and Trump et al., from destroying our scientific ecosystem. We are fueled by small donors--plz chip in if you are able. If you're a big donor PLZ SUPPORT US! www.standupforscience.net/donate
Fuel the fight! — STAND UP FOR SCIENCE
standupforscience.net
☕Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and interferes with the cytoprotective roles of PABPC1 and MKRN1. bit.ly/49kgpZN
The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology
Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...
bit.ly
Our paper is now out in @natcellbio.nature.com! @craigmcrews.bsky.social www.nature.com/articles/s41... We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology
Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...
nature.com
Our paper is now out in @natcellbio.nature.com! @craigmcrews.bsky.social www.nature.com/articles/s41... We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.
The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology
Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...
nature.com
The international boycott of ChatGPT has absolutely exploded. 2.5M people have already joined, and this is just the beginning. Go to quitgpt.org. Cancel your subscription, delete your account. And tell at least one person why. My op-ed: www.theguardian.com/commentisfre...
This project started with confusion 🤔 www.nature.com/articles/s41... Loss of LUBAC or OTULIN causes severe inflammatory disease. But patients also show clear metabolic defects. Neither LUBAC nor OTULIN had been linked to metabolic regulation. So where do these metabolic manifestations come from?
Rune Busk Damgaard@rbdamgaard.bsky.social · 6mo ago🧐 What if metabolic defects are not just a consequence of inflammatory disease - but actively contribute to it? Inflammation and metabolism are deeply intertwined, but the molecular links remain unclear. Our new paper in Cell Death & Differentiation uncovers one. 🧵👇 nature.com/articles/s41...
So moved by the people of Minnesota who—drawing on LA, Portland, Chicago, DC etc—are writing a shining new chapter in the history of nonviolent resistance. The rest of us need to be taking notes—and helping them! www.standwithminnesota.com
Stand With Minnesota
A directory of places to give to as Minnesota defends itself from ICE occupation
standwithminnesota.com
2025 sucked. In 2026, we are taking back our science! We are excited to launch our Substack: The Science Fight Club. Read our first post, written by @cdelawalla.bsky.social, a review of 2025, a preview of 2026, and a big call to action. open.substack.com/pub/sciencef...
In thinking about what you can do this year, keep this in mind: showing up at protests has real impact - - www.theguardian.com/us-news/2025...
How effective is protesting? According to historians and political scientists: very
From emancipation to women’s suffrage, civil rights and BLM, mass movement has shaped the arc of US history
theguardian.com
Under Trump, the draconian future of homelessness policy is coming into focus: mass internment. Utah is building a 16-acre site to detain up to 1,300 homeless people inside locked "accountability centers." This is profoundly alarming. Vital reporting from @ellenbarry.bsky.social and Jason DeParle:
In Utah, Trump’s Vision for Homelessness Begins to Take Shape
nytimes.com
"22 of Earth's 34 'vital signs' are flashing red, new climate report reveals — but there's still time to act" | Nice article on our new #Bioscience article by @saschapare.bsky.social for @livescience.com: www.livescience.com/planet-earth...
22 of Earth's 34 'vital signs' are flashing red, new climate report reveals — but there's still time to act
Earth's systems are nearing tipping points that could plunge the planet into a "hothouse" regime — but there's still time to prevent that from happening, scientists say.
livescience.com
Dear all, A scientist from UNC Chapel Hill, Paul Maddox, is running for congress in NC for a seat currently held by a republican. If you care about science (and democracy) please consider donating to his campaign #Standupforscience secure.actblue.com/donate/paul-...
Donate to Paul Maddox for Congress in NC 11
Paul is running for Congress because there’s a sickness in Washington, and no one is working to cure it.
secure.actblue.com
In @nytopinion.nytimes.com “Gaza represents not some distant and inevitable tragedy, but our own moral and practical failing,” our columnist Nicholas Kristof writes. “We have blood on our hands.”
Opinion | Answering My Critics About the War in Gaza
Why I believe American support for Israel in this conflict is a moral and practical failure.
nyti.ms
BBC International Editor Jeremy Bowen has confirmed that the entire Al Jazeera team in Gaza City has been killed.
This is the first example I've seen of a university trying to mobilize constituents to stand up against Trump threats. There's been a lot of "wHaT eLsE CaN AdMiNiStRaToRs Do?" in The Discourse when this is exactly the thing they haven't been doing. Good for UCLA for trying. Others should follow.
Miriam Posner@miriamposner.com · 12mo agoI’m heartened to see this.
Scientists decry Trump energy chief’s plan to ‘update’ climate reports: ‘Exactly what Stalin did’ [yeah, that was me] | Mark Oliver for @theguardian.com: www.theguardian.com/us-news/2025...
Scientists decry Trump energy chief’s plan to ‘update’ climate reports: ‘Exactly what Stalin did’
Ex-fossil fuel executive Chris Wright said administration is reviewing national assessments made by past governments
theguardian.com
Given the state of things, self promotion is weighed down by extra shame and dissonance these days, but here is some personal news anyway: I have Emerged, per @weillinstitute.bsky.social! Very grateful for this award and the opportunity to share my work from @craigmcrews.bsky.social's lab.
Weill Institute for Cell & Molecular Biology@weillinstitute.bsky.social · last yr.We’re thrilled to announce our Weill Institute 2025 Emerging Scholars –– eight outstanding grad students & postdocs selected for their innovative research, from institutions across the US and Canada. We'll welcome them to Cornell’s Ithaca campus Oct 13–14, 2025. news.cornell.edu/stories/2025...
