Introducing Foli-seq in @natbiotech.nature.com today. Foli-seq can be used to measure gut-derived RNA from fecal matter (signals of immune, secretory & epithelial cells). We used this to map gut inflammation, drug response, and host-microbe interactions. 💩🧬💊🦠 www.nature.com/articles/s41...

Fecal exfoliome sequencing captures immune dynamics of the healthy and inflamed gut - Nature Biotechnology

Profiling host RNA shed in feces reveals disease states in the gut.

nature.com

🚨I am looking for a POSTDOC, LAB MANAGER/TECH and GRAD STUDENTS to join my new lab in beautiful Madison, WI. We study how our brains perceive and represent the physical world around us using behavioral, computational, and neuroimaging methods. paulunlab.psych.wisc.edu #VisionScience #NeuroSkyence

Another review from my lab out this week, on analyzing gut microbiome data from global populations -- tackling computational challenges and providing practical frameworks and resources for the field With Sabrina Arif, @richabdill.com, @samanthagraham.bsky.social www.cell.com/trends/micro...

Analyzing human gut microbiome data from global populations: challenges and resources

Research on the human gut microbiome is expanding rapidly; yet, most published studies focus on populations from high-income regions such as North America and Europe. Underrepresentation of population...

cell.com

Metabolic ecology of microbiomes: Nutrient competition, host benefits, and community engineering Review by Erik Bakkeren, Vit Piskovsky, and Kevin R. Foster www.cell.com/cell-host-mi...

📈With obesity and overweight expected to affect 50% of the global population by 2035, the need for change has never been clearer. Join experts on 5 June at #EUParliament for an in-depth discussion on tackling this growing health crisis. Register now: https://bit.ly/3EIlu1H

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

Inflammasome signaling in astrocytes modulates hippocampal plasticity

The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...

cell.com

Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS: www.sciencedirect.com/science/arti...

Interoceptive processing in the nucleus of the solitary tract

The interoceptive nervous system continuously monitors the status of visceral organs to synthesize internal perceptions and regulate behavioral and ph…

sciencedirect.com

www.nature.com/articles/s41...

Stress dynamically modulates neuronal autophagy to gate depression onset - Nature

Acute stress activates autophagy in the lateral habenula, whereas chronic stress suppresses it, with this autophagy having a causal role in maintaining emotional homeostasis against stress, and its re...

nature.com

NEWS&VIEWS | LO Dragsted, @hroager.bsky.social , @catalinacuparencu.bsky.social (U Copenhagen): A methodology for assessing dietary intake using stool metagenomes to detect food DNA🧬💩 https://bit.ly/4lfJ1aK ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab

Querying stool for dietary information - Nature Metabolism

Accurately determining food intake remains a substantial challenge in nutrition research. This issue of Nature Metabolism introduces a methodology for assessing dietary intake, using stool metagenomic data to detect food DNA from a broad range of foods.

bit.ly

A map of neural signals and circuits traces the logic of brain computation www.nature.com/articles/d41...

A map of neural signals and circuits traces the logic of brain computation

A large consortium of scientists adds functional data to neuronal wiring maps, seeking to crack the computational circuitry of the mouse brain.

nature.com

Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: @cellpress.bsky.social www.cell.com/cell/fulltex...

In people with diabetes, GLP-1 and SGLT2i drugs were associated with less Alzheimer's disease and related dementias jamanetwork.com/journals/jam...

I am excited to share our latest publication where we investigated the impact of a #Bifidobacterium longum strain on #perinatal anxiety and depressive symptoms #mood #stress #postpartum #gutbrainaxis www.nature.com/articles/s41...

The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trial - Scientific Reports

Scientific Reports - The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trial

nature.com

The gut microbiome's link with multiple sclerosis www.cell.com/cell-reports...

Delighted our study (7+ years in the making) is out today in Nature. In a nutshell, 48 hours of antibiotics in week 1 led to impaired vaccine responses up to 15 months later in infants. We show (in-vivo) a probiotic can fix it #microbiome #science #immunology www.nature.com/articles/s41...

Bifidobacteria support optimal infant vaccine responses - Nature

Neonatal antibiotic use is shown to reduce immune response to infant vaccines, accompanied by reduced abundance of Bifidobacteria in the gut microbiota, with experiments in mice indicating that probio...

nature.com

Singapore study of 184 women found that daily probiotic Bifidobacterium longum NCC3001 during late pregnancy and postpartum did not ease anxiety or depression symptoms. Results varied widely, suggesting more research is needed. www.nature.com/articles/s41...

The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trial - Scientific Reports

Scientific Reports - The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trial

nature.com

Curious about the gut microbiome & its impacts on sleep throughout the adult lifespan? 🦠😴 You're in luck! @isbscience.org PhD student Jacob Cavon led a review of this topic for the @amiposts.bsky.social journal Letters in Applied Microbiology (just accepted): academic.oup.com/lambio/advan...

The human gut microbiome and sleep across adulthood: associations and therapeutic potential

Abstract. Sleep is an essential homeostatic process that undergoes dynamic changes throughout the lifespan, with distinct life stages predisposed to specif

academic.oup.com

I received a heartbreaking email today: A paper in a special issue I’m editing is being retracted because one of its authors is afraid of losing their job and their legal status in the U.S. if they publish a scientific study on evolution. Yes, on evolution, nature's engine of diversity.

In this week’s @nature.com, we publish a group effort to outline a framework for studies with neural #organoids, #assembloids and transplantation. More details below 1/n

Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide www.nature.com/articles/s41...

This administration is destroying US science. "Foreign scientists hired under Title 42 have even more reason to worry... their visas require they leave the country within 60 days unless they obtain a new position. Many have put down roots, bought houses & have children in school."

TK (Takashi DY) Kozai@bioniclab.bsky.social · last yr.

www.science.org/content/arti...

What is your pace of aging? A new @nature.com feature on molecular clocks by gets into the issues surrounding these tests (can is really can't) nature.com/articles/d41... by @heidiledford.bsky.social

Great minds… within 24 hrs both us at @nature.com and @science.org make similar appeals to the research community. And @holdenthorp.bsky.social and I didn’t even exchange notes about it ;-) 🧪 www.nature.com/articles/d41... www.science.org/doi/10.1126/...

Come together, right now

The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...

science.org

Almost all grant-review meetings under Trump 2.0 remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion annual budget. https://go.nature.com/4gM6oW4

Revealed: NIH research grants still frozen despite lawsuits challenging Trump order

The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.

go.nature.com

My brother is a wild-land forest fire fighter. He wasn’t fired, but he says that the degraded workforce will struggle to function in the next fire season. These are the heroes who risk everything to save lives and homes.

AltYellostoneNatPar@altyellonatpark.org · last yr.

Another illegal act by the current administration. www.politico.com/news/2025/02...

Interested in doing a PhD in Austria focused on understanding how to engineer the composition of the gut microbiota? Want to work with a brilliant computational biologist and microbiome researcher? See below!

Christian Diener@cdiener.com · last yr.

Hi, we have an open PhD position in our lab starting winter 2025. Join the great MolMed PhD program at a vibrant research institution and help us understand probiotic engraftment. More info at www.dienerlab.com/posts/phd2025/ . Application through the MedUni portal: phd-recruiting.medunigraz.at

A new way to measure your food intake, from your 💩 www.nature.com/articles/s42... www.nature.com/articles/s42... "proof-of-concept for detailed tracking of individual-specific, health-relevant dietary patterns without the need for questionnaires."

Querying stool for dietary information - Nature Metabolism

Accurately determining food intake remains a substantial challenge in nutrition research. This issue of Nature Metabolism introduces a methodology for assessing dietary intake, using stool metagenomic...

nature.com

Just to add to the impossibility of doing a fully double blind randomized trial for a communicable desease, the placebo group would need to be tested in a population that is not significantly protected by herd immunity to see the effect if the general population stops taking the vaccine. Where??

Introducing "Metagenomic Estimation of Dietary Intake", or "MEDI": a data-driven approach to estimating dietary and nutritional intake from stool DNA 💩 - 🍌🥦🐟🥩📈 See @cdiener.com's excellent thread below. We are really proud of this work, and we hope it is useful to the scientific community.

Christian Diener@cdiener.com · last yr.

Happy to announce that MEDI, our method to quantify dietary intake through metagenomics is out now. 🧬 🧪🧫🦠 www.nature.com/articles/s42... #metagenomics #microbiome #microbiomesky So what is MEDI? A combination of two things:

If this sticks, it will destroy academic science in the US, and it will stifle technological innovation and economic growth. It cannot stand. Contact your representatives and senators.

Carl T. Bergstrom@carlbergstrom.com · last yr.

6. The policy does not just affect funding going forward. All existing NIH grants will have their indirect rates cut to 15% as of today, the date of issuance. For a large university, this creates a sudden and catastrophic shortfall of hundreds of millions of dollars against already budgeted funds.