New preprint from the lab! Riboswitches toggle by rearranging base pairs. Can you get the same toggling without changing the secondary structure? Turns out yes. We designed a minimal modular RNA that forms or breaks a tertiary contact in response to ligand binding. www.biorxiv.org/content/10.6...

Single-base substitutions switch RNA tertiary allostery between positive and negative coupling.

Riboswitches regulate gene expression in response to ligand binding, remodeling their secondary structure to terminate transcription or block translation. This innate switching has driven efforts to r...

biorxiv.org

📣NAR is recruiting a new Executive Editor!📣Seeking an established researcher with expertise in RNA biology and translation mechanisms to help shape the journal's scientific direction, oversee peer review, and support its growth. Apply by 30 Sept 2026: academic.oup.com/nar/pages/ex...

New preprint from Kaley Simcox in the Koutmou lab! She developed a HILIC-MS/MS approach for total tRNA sequencing, achieving 75–100% coverage for most isoacceptors - without ion-pairing reagents. This enabled the discovery of new modified positions on E. coli tRNAs. doi.org/10.64898/202...

Hot off the press from the RTI: The Pseudomonas aeruginosa ribonuclease Ribocin cleaves eukaryotic ribosomes at helix 69 to inhibit host translation pubmed.ncbi.nlm.nih.gov/42160310/?ut... #RNA #RNATherapeutics

The Pseudomonas aeruginosa ribonuclease Ribocin cleaves eukaryotic ribosomes at helix 69 to inhibit host translation - PubMed

Pseudomonas aeruginosa employs host translation inhibition as a virulence-enhancing strategy. We previously showed that the bacterium induces cleavage of Caenorhabditis elegans large ribosomal RNA at...

pubmed.ncbi.nlm.nih.gov

Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...

WOOOO! Congrats, @heatherfeaga.bsky.social!!! @cornelluniversity.bsky.social

Hypothesis Fund@hypothesisfund.bsky.social · 6mo ago

5/ Awardee @heatherfeaga.bsky.social is investigating how bacteria decide when to go dormant💤 (ie, form spores). Her project could lead to important new advancements in the management of spore-forming bacteria in the environment, hospitals, & food supply. 🎉 Congrats Dr. Feaga! 🙏 #HFScout Dipti Nayak

Check out our new preprint on IRES studies (www.biorxiv.org/content/10.6...). We show a recently proposed IRES “toolbox” results in mRNA annotation errors and false-positive IRES activities. We provide an alternative set of robust approaches. (1/4)

So, so, honored by this award—it is daunting to know that my heroes have won this award! Thanks to my heroes and mentors, and my trainees, who are everything!!!!

U of Utah Dept of Biochemistry@uofubiochem.bsky.social · 8mo ago

A huge congratulations to Brenda Bass @bbass.bsky.social for her Lifetime Achievement Award from the RNA Society @rnasociety.bsky.social! She is being recognized for her "groundbreaking discovery of A-to-I editing and outstanding contributions to this field."

Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine. faculty-einstein.icims.com/jobs/17847/a...

🧪 My lab has an opening for a postdoc position soon! Please share/get in touch!

We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT

Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)

Some things I’m very proud of from my group in no particular order: three selected talks! We work so hard on communicating our science clearly and effectively that I am especially proud of this

Hey all, I reached out to the PO of my NIGMS MIRA to ask if the gov't shut down, and rescheduling of study sections, might allow for some accommodation to the standard rule that PIs cannot resubmit a MIRA while their MIRA (or other RPG) is under review (waiting in scores or summary statements) 🧪

New work led by Madison Bandini out in @pnas.org using live cell imaging to show how HIV targets the cell cycle to double viral genomes and increase transcription. Awesome collaboration with cell cycle heroes in Suzuki lab @mcardlelab.bsky.social @uwmadison.bsky.social. www.pnas.org/doi/10.1073/...

My talk from the latest RNA Collaborative Seminar Series is now available on YouTube. The second talk in the session was given by Rachel Braun (Sara Cherry’s lab) on TTP and its role in regulating antiviral immunity. youtu.be/2Aj-xbi3dPI #RNAsky #RNAbiology

December 10: NCI RNA Biology Initiative & Penn Institute for RNA Innovation

YouTube video by RNA Collaborative Seminar Series

youtu.be

I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...

Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...

Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668

The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a   Tenure Track Professors...

nature.com

Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!

Anyone at Harvard need a super well-trained undergrad next semester? Cell culture, molecular bio, microscopy and data analysis. Very careful and rigorous. Good lab citizen. Ready to jump in and learn/get some data! Has light course load, so plenty of time for research! Let me know of any leads!

📢 We are pleased to announce the Molecular Mechanisms of RNA in Disease – The NCCR RNA & Disease Final Symposium Jan 26-29, 2026, in St. Moritz! 🔗 Details & updates: finalsymposium.nccr-rna-and-disease.ch @snf-fns-ch.bsky.social @unibe.ch @ethzurich.bsky.social

#RNAsky #RNAbiology

Green Lab JHMI@greenlab.bsky.social · 11mo ago

Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫 www.nature.com/articles/s41... A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social

From @kylecottrell.bsky.social lab rnajournal.cshlp.org/content/31/1...

Registration is open for "The complex life of #RNA" 2026 @embl.org in Heidelberg! Excellent invited speakers and 30 short talks and even more flash talks selected from the abstracts!

EMBL Events@events.embl.org · 11mo ago

Come discuss recent breakthroughs in RNA biology, from molecules to organisms, at the EMBO | EMBL Symposium 'The complex life of RNA'! 👉 s.embl.org/ees26-12-bl Submit your abstract by 7 July and present your research at #EESRNA 🥼

Thank you to our sponsors for the GA RNA Salon @rnasociety.bsky.social and Lexogen- we hosted Dr. Francesca Storici for our annual symposium yesterday @dunhamlab.bsky.social @ghaleilab.bsky.social

Dang, hard disagree. The best papers to write and read are works of art, not merely a list of data and statements. Don’t let LLMs take this away too, for gods sake.

Blake Richards@tyrellturing.bsky.social · 11mo ago

I honestly think we would all be a lot more productive if papers were bullet points with plots.

Latest from the lab! Analysis of everyone’s favorite regulatory mechanism in bacteria — the RF2 programmed frameshift! Likely present in the ancestor of bacteria, use of this mechanism is influenced by stop codon usage! Big congrats to @cassidyprints.bsky.social journals.asm.org/doi/10.1128/...

Conservation and evolution of the programmed ribosomal frameshift in prfB across the bacterial domain | mBio

Translation termination is catalyzed by one of two release factors in bacteria, RF1 or RF2. It has been known for decades that RF2 levels in Escherichia coli are regulated by a programmed ribosomal frameshift within the prfB gene that encodes RF2. We ...

journals.asm.org

Very proud of our recently published work in @narjournal.bsky.social led by senior PhD candidate Julia Warrick. #RNA academic.oup.com/nar/article/...

An autism spectrum disorder mutation in Topoisomerase 3β causes accumulation of covalent mRNA intermediates by disrupting metal binding within the zinc finger domain

Abstract. The loss and mutation of Topoisomerase 3β (TOP3B), the only known eukaryotic topoisomerase with the ability to catalyze RNA strand passage reacti

academic.oup.com

Great lab, great mentor and I love UNC Biology!

Parul Johri@johriparul.bsky.social · 11mo ago

The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.

The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.