In a new (ish) preprint, we used CRISPR barcodes to label germline stem cell clones in zebrafish, then tracked their contributions to sperm production for 2 years. Instead of staying stable, individual clones rose, fell, and disappeared over time. www.biorxiv.org/content/10.6...

Clonal dynamics deviate from neutral drift in zebrafish spermatogenesis

Spermatogonial stem cells (SSCs) maintain male fertility, but how their clonal dynamics change with age remains poorly understood. Here, we use in vivo CRISPR barcoding in zebrafish to label SSCs and ...

biorxiv.org

We are happy to present a new paper on the sequence dependence of 🧬 replication timing in the cell cycle. www.biorxiv.org/content/10.6... 🧵 1/6

Using Deep Learning to predict replication timing reveals baseline control of genomic DNA sequence

Human DNA replicates according to a precise schedule: certain regions are replicated early, while others replicate later in the cell cycle. The DNA sequence and the epigenome are both indicative for r...

biorxiv.org

RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...

Analog intrinsic recoding measures RNA dynamics without chemical conversion

Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...

biorxiv.org

I’ve had the privilege of working with countless people over many years: doing (thousands) of experiments in the @odomlab.bsky.social, before joining forces with @paulflicek.bsky.social @nlbigas.bsky.social @csemple.bsky.social - and of course Martin Taylor @mstaylor.bsky.social and team. [11/14]

🧬NEW PAPER🧬 To what extent is cancer development deterministic? Does the germline genome affect that predictability? Find out in our #StrainDifferences paper @nature.com "Genetic background sets the trajectory of experimental cancer evolution" www.nature.com/articles/s41... 🧵[1/14]

Genetic background sets the trajectory of experimental cancer evolution - Nature

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...

nature.com

Fantastic to see this out. Everyone on it is fab and has produced an incredible resource @s-j-aitken.bsky.social @mstaylor.bsky.social @odomlab.bsky.social

Barbara Marte@barbmarte.bsky.social · 2w ago

new out in Nature www.nature.com/articles/s41...

How do somatic mutations accumulate in healthy tissues? This preprint analyzes nearly 12,000 normal samples across 25 tissues, uncovering ongoing mutagenic processes and providing a framework for studying somatic mutations in normal human cells. www.biorxiv.org/content/10.1...

Motif-Centered Analyses Reveal Universal and Tissue-Specific Mutagenic Mechanisms Operating in the Human Body

Somatic mutations are inevitable in human genomes and can lead to tumorigenesis, yet baseline mutagenesis in non-cancerous normal cells remain poorly understood. Here, we analyzed the mutation profile...

biorxiv.org

What if DNA methylation changes aren’t just ticking of our biological clock but rather the rust breaking the gears? Very excited to share our work - how DNA methylation contributes to stem cell dysfunction and aging, published in @natgenet.nature.com doi.org/10.1038/s415... #epigenetics #aging 1/11

A progeria syndrome links DNA hypermethylation to age-related pathology - Nature Genetics

This study investigates the consequences of hypermethylation in a progeria syndrome caused by gain-of-function DNMT3A mutations, finding effects on adult stem cell function.

doi.org

Please join us in NH (perfect place to be in August!) for this inspiring conference organized by @petrovadmitri.bsky.social and Joy Bergelson. Very interdisciplinary, so I look forward to learning tons of new concepts. www.grc.org/function-of-...

Please help me find a great student! I have a PhD position in my lab in Munich, looking at the dynamics of DNA damage and repair from chemotherapy: jobs.dkfz.de/en/jobs/1686... The application deadline is 02.07.26 @dkfz.bsky.social @lmu-klinikum.bsky.social

PhD Student in Mutagenic Chemotherapy Driving Treatment Resistance

jobs.dkfz.de

Now published: journals.plos.org/plosbiology/...

What sets the mutation rate of a cell type in an animal species?

Mutation rates per generation are strikingly similar across germlines of animals and across at least one somatic cell type, suggesting a key role for natural selection in shaping mutation rates. This ...

journals.plos.org

Molly Przeworski@mollyprz.bsky.social · 8mo ago

Happy to highlight an essay I wrote together with @marcdemanuel.bsky.social, @natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n

FYI: New online! Evolutionary genetics of ageing

Evolutionary genetics of ageing

Nature Reviews Genetics, Published online: 11 May 2026; doi:10.1038/s41576-026-00959-xModern humans increasingly live long enough to experience late-life consequences of genetic and molecular systems shaped by natural selection. In this Review, the authors integrate evolutionary genetics and genetic evidence to explain why ageing evolves, why longevity varies across species and individuals, and how these insights inform healthspan extension.

dlvr.it

Interested in DNA damage and the mechanisms of mutagenesis? We are hiring post-doctoral scientists as part of the amazing CAUSE Cancer Grand Challenge team. Biochemistry, genomics and computational biology... tinyurl.com/yc5xs3wa tinyurl.com/4unu5uu9 CAUSE www.cancergrandchallenges.org/cause

We are looking for a Data and IT manager. You would set up the group’s data infrastructure, data flows, and overall organization on HPC. We aim to understand genomes 🧬 and ageing 👵 with Big Data and Machine / Deep Learning. Interested? Please apply through jobportal.uni-koeln.de/ausschreibun...

Complementing our recent #Review 'Charting single-cell lineages with synthetic and natural barcodes' by @alejofraticelli.bsky.social & Victoria Parreno (rdcu.be/e50gy), Kun Wang, Xionglei He & Zheng Hu review 'Computational approaches for multimodal lineage tracing': go.nature.com/4nDGGbk

Computational approaches for multimodal lineage tracing - Nature Reviews Genetics

Multimodal lineage tracing links heritable ancestry with single-cell molecular states to reveal how cell fates emerge during development, regeneration and disease. In this Review, the authors survey k...

go.nature.com

new out in Nature www.nature.com/articles/s41...

Ecotypes of triple-negative breast cancer in response to chemotherapy - Nature

Treatment data for triple-negative breast cancer show the importance of macrophage subtypes and cancer-cell metaprograms for interferon signalling, HLA expression and cell cycle activity that are asso...

nature.com

A gene is recurrently mutated in cancer. But do these mutations really cause the disease? Or are they merely selected during normal tissue evolution? Postdoc D. Cheek had the creative idea to use patient ages to try and answer this question. Read new paper out here: www.nature.com/articles/s41...

Age distinguishes selection from causation in cancer genomes - Nature Genetics

Mutations may be enriched in tumor samples because they promote carcinogenesis or because they promote clonal expansions in healthy tissue. This study mathematically disentangles these two possibiliti...

nature.com

📣 EvolDir is now managed by @eseb.bsky.social! We are delighted to be taking the reins and express our gratitude to both Brian Golding who began this service to the community in the mid-1980s and to @rdmpage.bsky.social who ran this account until now 👏 You can now find evoldir here: evoldir.net

Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr

Caroline Watson gives the first talk at the Mutations in Time and Space conference on the evolutionary road to AML #MITS2026

Pei-Chi Wei from @dkfz.bsky.social is the last speaker for Mutations in Time and Space 2026. Thanks to everyone who made it such a phenomenal meeting #MITS26

Great talk!! @imartincorena.bsky.social #mits26 Can't wait to read the paper: www.nature.com/articles/s41...

I'm currently on my way to Hinxton for Mutations in Time and Space 2026. The attendee list is insane and I can't wait to see everyone- it's going to be a thrilling few days! #MITS26 coursesandconferences.wellcomeconnectingscience.org/event/mutati...

In vivo lineage tracing across human tissues using methylation barcodes in the protocadherin gene cluster https://www.biorxiv.org/content/10.64898/2026.02.23.707349v1

🧬🧬🧬 REGISTRATION JUST OPENED! Make sure you join our DNA REPAIR MEETING 2026 ON PHYSIOLOGICAL CAUSES AND CONSEQUENCES OF GENOME INSTABILITY in Cologne, September 7-9, organized by the German Society for DNA Repair (DGDR) and the @dfg.de Research Unit 5504. www.for-5504.com/en/197/Confe...

The abstract deadline for Mutations in Time and Space 2026 closes in 3 weeks time. Sign up here: coursesandconferences.wellcomeconnectingscience.org/event/mutati... As well as thrilling science, the programme includes dinner at the beautiful King's College in Cambridge. @eventswcs.bsky.social

Nature research paper: Decay of driver mutations shapes the landscape of intestinal transformation go.nature.com/49VIh7w

Decay of driver mutations shapes the landscape of intestinal transformation - Nature

The order in which driver mutations of colorectal cancer occur in intestinal epithelium can determine whether clones are positively or negatively selected and can shape subsequent tumour development.

go.nature.com

For those interested in cooperativity within and between enhancers, @wbickmor.bsky.social and I wrote a mini-review and perspective, inspired by the many recent papers on this topic. doi.org/10.1016/j.gd...

Somatic and germline mutational processes across the tree of life https://www.biorxiv.org/content/10.64898/2025.12.28.691837v1

www.nature.com/articles/s41...

Spatial architecture of development and disease - Nature Reviews Genetics

Spatial omics has empowered the discovery of developmental and disease-associated molecular signatures, cell states and multicellular niches, as well as the evaluation of disease heterogeneity within ...

nature.com