Day 1 of “Build Your Own Protein from Scratch” at @institutpasteur.bsky.social , hands-on AI in structural biology 💁🏻‍♂️. Two days in, already rethinking how fast protein design is moving.

Slicing reality at 100 nm, where #fluorescence meets #electron density, and the cell finally shows its true face. Cryo-sectioning for Super Resolution #CLEM ✨🔬😏 #Tokuyasu’sDay

A delightful read for the weekend!!!

@satooze.bsky.social · 3mo ago

Delighted to share our recent review 😊 enjoy! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

I ordered some coverslips for super-resolution from @thorlabs.bsky.social First time ordering from this company, and I would have NEVER expected to find also this inside the package 😭🥹Had I known earlier, I wouldn’t have spent so much of my life missing out on these kinds of gifts 💁🏻‍♂️🤩 🍫

Me as a PI: “this paper is 95% done” The remaining 5% are figures 3-8 and all of the writing

Ol' Chef Dan@olchefdan.bsky.social · 3mo ago

Honestly, one of the funniest tweets I've ever seen.

POSTDOC OPPORTUNITY!!! The Rutgers IRACDA program is phenomenal: 70% of postdoctoral fellows land faculty positions. Martha Soto (LinkedIn below) is the amazing director and leader of this program. Please apply or reach out if you have questions. www.linkedin.com/posts/martha...

INSPIRE is recruiting! Please share broadly with senior graduate students and beginning postdocs. INSPIRE, the NIH-funded Rutgers-IRACDA, offers postdoctoral training for individuals interested in… | ...

INSPIRE is recruiting! Please share broadly with senior graduate students and beginning postdocs. INSPIRE, the NIH-funded Rutgers-IRACDA, offers postdoctoral training for individuals interested in com...

linkedin.com

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

Today I presented a fresh paper (out 2 days ago in @jcb.org) during our lab literature session. Really nice work from Suzuki’s Lab using the R18 lipid dye to map ATG2-dependent lipid transfer from the ER to autophagy structures in vivo ☺️ revealing a how R18 reaches ER-IM contacts shorturl.at/hZR8k

One week left to register to the Bioimage Analysis with AI course in Pasteur! This June, 1 - 5. I give a bit more details in the thread below 👇

Institut Pasteur Education@pasteuredu.bsky.social · 6mo ago

⚠️ 1 week left for Pasteur Course "Advanced Bioimage Analysis With AI"! 👩‍🔬💻 Intensive course (June 1-5, Paris): theory + hands-on, AI focus in bioimaging. 📍 Institut Pasteur 🗣️ English ⏰ Deadline: March 1 🔬 Beginner basics, batch scripts, interactive sessions 👉 Apply: https://bit.ly/4c8rFKZ

Paris ❄️🥹

Latest preprint from our lab reports that the distinct pH of anterograde (less acidic) and retrograde (more acidic) lysosomal vesicles in the axon depends on assembly of the V1 and V0 domains of the vacuolar H+ ATPase, mediated by the metazoan RAVE complex www.biorxiv.org/content/10.6...

We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)! GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging. Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations. 👉 www.unige.ch/genexm/

Great seminar today at Institut Pasteur by Dr. @abdourachidthiam.bsky.social (ENS Paris): “From the physics to the cell biology of fat storage.” He presented a beautiful integration of physics and cell biology to explain how lipid droplets are born at the ER and how ATG2 support their growth 🤩

www.nature.com/articles/s41...

Online now - the Review " #Autophagy regulation by phase separation, avidity, and wetting" from @wilflinglab.bsky.social, @kraftlabfr.bsky.social and co. #BiomolecularCondensates #PhaseSeparation #Wetting #Avidity #Theraeputics Read it here: authors.elsevier.com/sd/article/S...

In this week's mitophagy news: -a novel screen for endogenous modulators of PINK1-Parkin pathway uncovers unstudied dependencies -autophagy regulation by phase separation, avidity and wetting -a bacterial mitophagy receptor to evade inflammation biomed.news/bims-tofagi/...

My quote of the day Leadership means forming a team and working toward common objectives that are tied to time, metrics, and resources. Russel Honoré

📈 Record interest in ERC Starting Grants 2026! 4,807 proposals - a 22% increase compared to last year’s call. 👩‍🔬 Women submitted nearly 43% of proposals - the highest share ever recorded in an ERC call. More stats 👉 bit.ly/4hcYJln #ChooseEurope

Starting Grants 2026 applications: Facts and figures

The ERC Starting Grants 2026 call closed for applications on 14 October 2025. These are the preliminary data on submitted proposals:

bit.ly

Excited to share our #BioSenSRRF preprint on bioRxiv! 🎉 We show how SRRF microscopy can be used with FRET-based biosensors to 🔬mitochondrial functions with high resolution 😍. Code and test data are open (GitHub + Zenodo). 👏 to Nicolas, Pierre-Jean, and co-authors! www.biorxiv.org/content/10.1...

Combining FRET and super-resolution microscopy reveals kinase activation and mitochondrial activity at the nanoscale

Protein kinases are key regulators of intracellular signaling, showing activities in specific subcellular compartments and in micro- or nano-domains. Genetically encoded biosensors based on Förster′s ...

biorxiv.org

Hi all. This is the recording of the online seminar I gave following the kind invitation of #GLOBIAS. I share what we have learned delivering #BioimageAnalysis services in the IAH core facility of the @institutpasteur.bsky.social research.pasteur.fr/en/team/imag... ⬇️

Image Analysis Hub - Research

The Image Analysis Hub is an open-access / equal-access core facility committed to sharing bioimage analysis services expertise with the scientific community. What we do The IAH works by collaborating...

research.pasteur.fr

GloBIAS@globias.bsky.social · 10mo ago

New video available in the #GloBIAS YouTube channel - we have uploaded the presentation by Jean-Yves Tinevz from September! tinyurl.com/5yc9p42k

I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Staff Scientist

About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...

embl.wd103.myworkdayjobs.com

Excited to share our latest manuscript by @saikat2025.bsky.social and an international team, reporting variants in the EARP- and GARP-interacting protein EIPR1 associated with a neurodevelopmental disorder. Will send you the PDF if you can’t access the article: academic.oup.com/brain/articl...

EIPR1 variants cause a neurodevelopmental disorder with endolysosomal and dense core vesicle defects

Abstract. EIPR1 (EARP-interacting protein 1, formerly known as TSSC1) is a WD40-domain protein that interacts with the EARP (endosome-associated recycling

academic.oup.com

This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 11mo ago

High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles https://www.biorxiv.org/content/10.1101/2025.09.08.674935v1

Excited to share the first paper from the lab! 🥳 The ATG9 and lipid droplets saga continues! Open source!

Liver-specific loss of Atg9a perturbs lipid metabolism and hepatocyte integrity

The autophagy-related protein ATG9A is integral to cellular autophagy and lipid mobilization, yet its importance in mammalian physiology remains underexplored. Using a liver-specific conditional At...

doi.org

New from @depaceraffa.bsky.social from our lab #NICHD #NIH in collaboration with Adeline Vanderver @childrensphila.bsky.social ‬and colleagues reporting mutations in the BLOC1S1 subunit of the BLOC-1 and BORC complexes in children with a neurodevelopmental disorder www.medrxiv.org/content/10.1...

These are the most challenging times for early-career scientists and engineers. My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers. We found 437 of them. Download it freely here: research.jhu.edu/rdt/funding-...

📆 Mark your calendars! The 2026 Keystone Symposium on Autophagy: Mechanisms to Therapy will take place February 2–5, 2026. 🔬 Check out the featured program and make note of key deadlines for registration and abstract submissions 👇

*ATG9A alert*👀👀 Curious about how ATG9A maintains lysosomal homeostasis via PI4P? Check out the new work from my postdoc in @satooze.bsky.social lab. Thrilled to see this finally published! Special thanks to @ealmacellas.bsky.social www.sciencedirect.com/science/arti...

ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair

Lysosome damage activates multiple pathways to prevent lysosome-dependent cell death, including a repair mechanism involving endoplasmic reticulum (ER…

sciencedirect.com

We are looking for someone to join the group as a postdoc to help us with scaling implicit transfer operators. If you are interested in this, please reach out to me through email. Include CV, with publications and brief motivational statement. RTs appreciated!