Finally out! I am super proud of this work that took 6 years to come to fruition, with many amazing people involved, in particular Sadegh, Ibrahim, Jelmer. #SadeghFeiz: all kudos for you to push this project through! Great Collab with Anssi Malinen from @utu.fi @vuamsterdam.bsky.social

bioRxiv Biophysics@biorxiv-biophys.bsky.social · yesterday

A multimodal, correlative magnetic tweezers-TIRF platform for high-throughput single-molecule interrogations https://www.biorxiv.org/content/10.64898/2026.08.11.744120v1

Spread the word! Registration is open for The Physics of Life at the Nanoscale meeting at the Aspen Center for Physics, Jan 3-8, 2027! This is an evolution of the popular Single Molecule Biophysics meetings (SMB). As always, there is a two step registration. Registration closes on Sept. 15, 2026!

Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.

The PoL research community committee tiny.cc/4ij7101 also organizes their PI meeting during the conference: Kristin Grußmayer, Jeroen van Zon, @alessandra-cambi.bsky.social, @damelab.bsky.social, @dulinlab.bsky.social, Christian Kaiser, Armagan Kocer, Nicholas Kurniawan, Camilla Terenzi, Rikfa Vlijm

Physics of Life (PoL) | NWO

Living systems comprise the most complex matter. Seeking a fundamental understanding of the processes that drive living systems pushes the boundaries of experimental and theoretical physics through the development of principles and concepts that balance the complexity of life with a physics-driven abstraction.

tiny.cc

The PoL research community committee tiny.cc/4ij7101 also organizes their PI meeting during the conference: Kristin Grußmayer, Jeroen van Zon, @alessandra-cambi.bsky.social, @damelab.bsky.social, @dulinlab.bsky.social, Christian Kaiser, Armagan Kocer, Nicholas Kurniawan, Camilla Terenzi, Rikfa Vlijm

Physics of Life (PoL) | NWO

Living systems comprise the most complex matter. Seeking a fundamental understanding of the processes that drive living systems pushes the boundaries of experimental and theoretical physics through the development of principles and concepts that balance the complexity of life with a physics-driven abstraction.

tiny.cc

research.pasteur.fr/en/call/mid-...

Mid-career Group Leader position in Chemistry for Health at Institut Pasteur, Paris - Research

Institut Pasteur and the CNRS are launching a joint call for a mid-career group leader position in Medicinal Chemistry and Chemistry for Health. We are looking for an experienced researcher (typically...

research.pasteur.fr

1/11 New preprint from the Sternberg lab in collaboration with the Fernández lab! We are excited to share our structure-function study of DRT10, a bacterial defense-associated reverse transcriptase that synthesizes long tandem-repeat DNA.🧵 Read the full story here: www.biorxiv.org/content/10.6...

Mechanism of tandem-repeat DNA synthesis by an antiviral reverse transcriptase

Defense-associated reverse transcriptases (DRTs) employ DNA synthesis to protect bacteria against phage infection[1][1],[2][2]. We previously showed that DRT10, a tripartite system comprising an RT, a...

biorxiv.org

We are looking for someone to lead the new Facility for Protein Biochemistry & Biophysics at the MPI of Immunobiology and Epigenetics in Freiburg — please spread the word and apply if you are interested!

Max Planck Institute of Immunobiology and Epigenetics@mpi-ie.bsky.social · 2mo ago

🚀 Job alert: We’re starting a new Facility – and you can lead it! The MPI-IE & @mariekeoudelaar.bsky.social are hiring a Head of Protein Biochemistry & Biophysics to launch and lead a brand-new Core Facility in Freiburg 🇩🇪. Once-in-lifetime-chance. Details ⬇️ jobs.ie-freiburg.mpg.de/jobposting/b...

My department @eth-dbiol.bsky.social at ETH Zurich is hiring for a tenured professor in mol cell bio and biochemistry (associate/full). The position is within the Institute of Biochemistry (www.bc.biol.ethz.ch) and it is fairly open within their scope of research. www.nature.com/naturecareer...

Professor of Molecular Cell Biology and Biochemistry - Zurich, Switzerland job with ETH Zurich | 12861386

The Department of Biology at ETH Zurich invites applications for the above-mentioned tenured professorship at the Institute of Biochemistry

nature.com

Come join the new Novo Nordisk Foundation Center for Protein Design as a group leader Cool science in a great scientific environment in wonderful and very family friendly Copenhagen There are two positions that can either be at TT assistant or associate prof level employment.ku.dk/tenure-track...

Tenure-track Assistant Professor or Associate Professor of De novo Protein Design

The Novo Nordisk Foundation Center for Protein Design at the University of Copenhagen seeks to appoint two new group leaders in de novo protein design from 1 February 2027 or as soon as possible thereafter. These positions will be at the Assistant or Associate Professor level and associated with the Department of Biology (Faculty of Science) or the Department of Drug Design and Pharmacology (Faculty of Health and Medical Sciences).

employment.ku.dk

Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir | Science Advances www.science.org/doi/10.1126/... #Coronavirus #SARS2 #COVID19 #singlemolecule #biophysics #magnetictweezers

Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir

Helicase-driven copy-back RNA synthesis in coronaviruses reveals how antivirals trap replication intermediates.

science.org

WORK: our Bionanoscience department at TU Delft is looking to hire an Assistant Professor in Biophysics of Living Systems. Apply! Deadline 30 July careers.tudelft.nl/job/Delft-As... RT=nice

Assistant Professor in Biophysics of Living Systems

Assistant Professor in Biophysics of Living Systems

careers.tudelft.nl

📢 We are looking for a Junior Group Leader to join us at @institutcurie.bsky.social! Having joined the department just over a year ago, I can honestly say that it is an exceptionally stimulating and supportive scientific environment, filled with outstanding colleagues — all in the heart of Paris.

📣 POSTDOC position available in the Feschotte Lab at Cornell to work on #TRANSPOSONS! More details below. Pls send informal application or inquiry ASAP by DM or email to cf458_at_cornell.edu. Pls spread the word 🙏 #TEsky www.thefeschottelabatcornell.com

Postdoctoral Position and PhD Fellowship in studies of the structure-function relationships and conservation of metabolic enzyme filaments in Kelli Hvorecny's newly established group at my department at the University of Copenhagen

Want to do a PhD combining cryo-EM, AI-driven binder design, and deep virology in a cutting-edge environment and in an international team? We're hiring @CSSB_Hamburg 🔬 You: curious, rigorous, MSc in biochem, biophysics, virology, related Interested? DM me. Please RT 🙏 #PhDposition #cryoEM #virology

Registration is opened for the FASEB conference DNA Topoisomerases in Biology and Medicine ! July 20th-23rd 2026, Nashville, TN Abstract Submission Deadline: Monday, May 25, 2026 Early Registration Deadline: Monday, June 8, 2026 #DNATopSRC John Nitiss, Valerie Lamour & Keir Neuman

Did you know that Pierre Chambon's laboratory was the first to use the term "nucleosome" in 1975 ? www.cell.com/cell/fulltex...

#RIP Pierre Chambon (1931-2026) 1963 PARP 1970 RNA Pol II 1975 Nucleosome 1977 Split genes 1980 Promoter 1983 enhancer 1986 Nuclear receptor

Please like, retweet, and share with your favorite colleagues! Try q.e.d here! qedscience.com (you just drop a file and 10-15 minutes later it's ready) (16/16)

q.e.d Science

Critical Thinking AI for constructive criticism and science evaluation

qedscience.com

📢 We are now recruiting a PhD student in Structural and Molecular Virology in Sweden 🇸🇪 Work on RNA viruses using cryo-EM and in situ cryo-ET, with access to world-class microscopy infrastructure Perfect for candidates with backgrounds in biochem, structural bio, and virology More info ⬇️

Open #postdoc fellowship in my group. Virus replication and cryo-ET. Projects can be tailored to ambitious candidates with diverse backgrounds, so don't hold back from applying! DM for more info. Deadline 22May. Apply here: umustipendie.varbi.com/en/what:job/... #virus #virology #teamtomo #cryoEM

Two open postdoctoral positions in my group at DAMTP, at University of Cambridge: Cell Biophysics & Biological Active Matter: www.damtp.cam.ac.uk/job/55046 Active & Intelligent Matter: www.damtp.cam.ac.uk/job/55141 Repost is much appreciated ! 🙏🏼 #Postdoc #CellBioPhysics #Robots #ActiveMatter

New preprint from the lab where we derived a simple and robust in situ force calibration method for high throughput #magnetictweezers that works even for short tethers and apply it to understand the mechanism of directional #mitochondrial #transcription termination by MTERF1.

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 4mo ago

Accurate single-bead force calibration in high-throughput magnetic tweezers reveals the mechanism of directional transcription termination by MTERF1 https://www.biorxiv.org/content/10.64898/2026.04.17.719150v1

The newly established NeCEN Utrecht is looking for a #cryoEM scientist! www.uu.nl/en/organisat... Work with a new Krios 5 + pFIB and support cutting-edge life science research. 📍 Utrecht | 🗓 Apply by 30 April Please share with your network!

Cryo-electron microscopy scientist

Join our team to contribute to the operation and innovation of state-of-the-art cryo-electron microscopes and empower groundbreaking research.

uu.nl

Postdoc opening with us at EPFL! Experimental project on how ATP driven chaperone cycles keep proteins out of equilibrium. We will quantify energy use, kinetics, and functional outcomes, including clients whose native-like functional state is stable only by sustained chaperone action.

A bit less recent work published in @narjournal.bsky.social led by Klein, Das and Bera. Great collaboration with many labs showing that SARS-CoV-2 polymerase must undergo an activation step to enable RNA synthesis. doi.org/10.1093/nar/... #SARSCoV2 #polymerase #RNAvirus #singlemolecule

Recent article from the lab published in @jacs.acspublications.org. Big congrats to first author Zainab Rashid for leading the study and great collaboration with @tomngrossmann.bsky.social and Jocelyne Vreede labs!😃 doi.org/10.1021/jacs... #singlemolecule #dsRNA #RNAtherapeutics

TAV2b Peptide Derivatives Underwind and Stabilize Double-Stranded RNA upon Binding

Double-stranded RNA (dsRNA) has become an essential tool to understand biological processes with promising therapeutic implications. However, its usage is often limited due to poor cellular uptake and...

doi.org

I was the last couple of days in Oxford to give a seminar, invited by my postdoc adviser @achilleskap.bsky.social. First time there since I left in 2016. I had a fantastic time, great discussions on science and else. Thank you Achilles for hosting me so well! 🤗

🧬📄 Preprint update (v2): We added new biochemical experiments that clarify how IWS1 associates with the transcription elongation complex and further define competition between IWS1 and RECQL5. 🧪⚙️ www.biorxiv.org/content/10.1... Structural model is already available in the PDB (9MLC).