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Pete Williams

@petetheteapot.bsky.social

Tea drinker and scientist. Neurons, NAD, stuff. Research Lead - Neuroprotection and Repair Unit at Centre for Eye Research Australia (petewilliamslab.com) CEO - Mim Neurosciences (mimneurosciences.com)

40 Posts1828 Follower3511 Folgt
Peter AF@doctorpaf.bsky.social · 11mo ago

In this review @Andrea-Loreto.bsky.social and I discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1 - Challenges for SARM1 therapeutic inhibition - SARM1 in non-neuronal cells - SARM1 activation for selective peripheral neuroablation. www.cell.com/trends/pharm...

Targeting SARM1: from inhibition for neuroprotection to activation for neuroablation

Sterile alpha and TIR motif-containing protein 1 (SARM1),is a central enzyme that drives programmed axon degeneration and has gathered significant interest as a therapeutic target. Despite preclinical...

cell.com

Flora Hui@florahui.bsky.social · last yr.

💉👀 Ozempic. What does the eye have to do with it? Let’s take a look at the latest evidence published in @jamanetworkopen.com Thank you to @aunz.theconversation.com for inviting me to write this piece. Was a pleasure to write with @petetheteapot.bsky.social from @ki.se

The Conversation AUNZ@aunz.theconversation.com · last yr.

A new study shows drugs such as Ozempic come with a small but increased risk of a condition known as an ‘eye stroke’. 👉 Read the full story: theconversation.com/ozempic...

Sketching Science@sketchingscience.bsky.social · last yr.

Doing science today feels like playing a video game on legendary difficulty. With shrinking budgets, extreme publication fees, subjective rejections, and daily lab chaos, the path of a scientist is tougher than ever. At least we have Parafilm to hold it all together. Stay strong, scientists.

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The New York Times@nytimes.com · last yr.

Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j49xBy

A baby surrounded by medical devices is being held up by someone with gloved hands. A headline reads: "Baby Is Healed With World's First Personalized Gene-Editing Treatment." Photo courtesy of Children's Hospital of Pennsylvania.
Thiago Carvalho@cyrilpedia.bsky.social · last yr.

'we define how mitochondrial gene expression is spatially organized at sub-organellar scales into regulatory hubs that are subject to stress-induced remodeling. We propose that this remodeling into mitochondrial stress bodies may serve to aid in recovery of mitochondrial proteome quality control'

Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress

Quantitative imaging of the mitochondrial central dogma identifies translation hubs that are suppressed during stress.

science.org

Thiago Carvalho@cyrilpedia.bsky.social · last yr.

“The visa fees are so exceedingly high that it makes coming here very difficult for some people. We are fishing for the best scientists in the world. They want to come and work here because we are such an effective country at science, but if we have these high costs, they can and will go elsewhere.”

Is the UK paying the price for world’s most expensive visas? | The Observer

Competing political and economic goals on immigration are resulting in the loss of valuable skills and talent in the UK

observer.co.uk

Nature Portfolio@natureportfolio.nature.com · last yr.

The authors of a Comment article in Nature write that hopes are high that AI can accelerate scientific discovery but warn that the rush to adopt AI has consequences. “Establishing clear scientific guidelines on how to use these tools and techniques is urgent.” 🧪

Why an overreliance on AI-driven modelling is bad for science

Without clear protocols to catch errors, artificial intelligence’s growing role in science could do more harm than good.

go.nature.com

Pete Williams@petetheteapot.bsky.social · 2y ago

My favorite thing about journal editors in the upper echelons of impact is that they deem my manuscripts of not being of sufficient quality or impact for their journal, but within the same week they are very happy to have me as a reviewer to judge said quality...

Pete Williams@petetheteapot.bsky.social · 2y ago

Another success for gene therapy! From The Lancet: Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study www.thelancet.com/journals/lan... #ophthalmology #genetherapy @

Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study

Our findings indicate that young children with AIPL1-related retinal dystrophy benefited substantially from subretinal administration of rAAV8.hRKp.AIPL1, with improved visual acuity and functional vi...

thelancet.com

Hilda Bastian@hildabast.bsky.social · 2y ago

Hate that it has come to this, but it's time to consider PubMed vulnerable to enshittification. My latest post @plos.org discusses the lines we need to fight to hold – and alternatives we can rely on internationally: absolutelymaybe.plos.org/2025/02/14/w... #medlibs

What if We Can't Rely on PubMed? - Absolutely Maybe

PubMed is incredibly reliable. And a lot depends on it. It’s an ecosystem built around MEDLINE, the steady feed of new publications…

absolutelymaybe.plos.org

Pete Williams@petetheteapot.bsky.social · 2y ago

** Phillips then said: “So no youth mobility scheme?” The home secretary said: “That’s not the right starting point for us at all because what we need to do is to bring net migration down.” ** Good times ahead for British science and academia /s www.huffingtonpost.co.uk/entry/yvette...

Yvette Cooper Rules Out The UK Signing Up To Giving Young People Free Movement To The EU

"That's not the right starting point for us at all," she told Sky News.

huffingtonpost.co.uk

Viktoria Cologna@colognaviktoria.bsky.social · 2y ago

Our global study on the state of trust in scientists is now out in Nature Human Behaviour! 🥳 With a team of 241 researchers, we surveyed 71,922 people in 68 countries, providing the largest dataset on trust in scientists post-pandemic 👇🧵https://www.nature.com/articles/s41562-024-02090-5

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Thiago Carvalho@cyrilpedia.bsky.social · 2y ago

“One thing that struck me is the visibility of people with smaller followings and early-career researchers,” say @jbakcoleman.bsky.social. That is particularly true in the feeds Bluesky lets users build themselves and that can include all posts related to a certain research field'

As academic Bluesky grows, researchers find strengths—and shortcomings

Platform fosters collegial interactions among scientists, but potentially limits interactions beyond the academic community

science.org