Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social Huge team effort, with immense contributions by friends from nearby and around the globe. www.science.org/doi/10.1126/...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel

Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

science.org

In this review @Andrea-Loreto.bsky.social and I discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1 - Challenges for SARM1 therapeutic inhibition - SARM1 in non-neuronal cells - SARM1 activation for selective peripheral neuroablation. www.cell.com/trends/pharm...

Targeting SARM1: from inhibition for neuroprotection to activation for neuroablation

Sterile alpha and TIR motif-containing protein 1 (SARM1),is a central enzyme that drives programmed axon degeneration and has gathered significant interest as a therapeutic target. Despite preclinical...

cell.com

A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 Oct. Not only did he make a discovery that laid the foundations for stem cell research, he also created one of the best environments for research at the Wellcome/CRUK Gurdon Institute wellcome.org/news/sir-joh...

Sir John Gurdon, 1933-2025 | Wellcome

A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 October. He made a discovery that opened up the field of cloning research, and created one of the best environments for res...

wellcome.org

It is 22 years ago today that my best friend, Nick Everton, died. He was 17 years old. Not much time to leave a mark on the world you would think. But those of us who knew him came away irreversibly altered by even the short time we shared together.... 🧵

It’s with a very heavy heart that I share with you the news that Prof Kristjan Jessen has passed away. Kristjan with his wife Rhona were at the forefront of the #Schwanncell field for over 3 decades. Kristjan was my first scientific mentor & he taught me a lot. He will be sorely missed.

Pleased to share our latest work on neural-immune interactions in aging white matter. It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations. Many thanks to everyone involved. www.nature.com/articles/s41...

Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - Nature Neuroscience

White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+ T cell recruitment, myelinated ax...

nature.com

Just finished the Peripheral Nerve Society meeting in Edinburgh #PNS2025. The last few days have been a whirlwind of science and medicine with inspiring talks and great posters in everything to do with peripheral nerve. It’s also been great to catch up with old colleagues.

I had a great experience publishing in @jcellsci.bsky.social - would highly recommend it!

Journal of Cell Science@jcellsci.bsky.social · last yr.

Did you know… It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳 For details, visit our website: journals.biologists.com/jcs/pages/re...

THREAD Things that didn't make the news that will likely change our lives for the better The news is not an accurate reflection of the world. Good news doesn't get reported as much. Here are the wonderful things researchers have achieved recently. 1/24

This sounds completely shocking. I really hope it’s not as bad as it sounds.

Jeremy Berg@jeremymberg.bsky.social · 2y ago

The damage today (actually yesterday) to the intramural program appears to especially bad. It also appears (although I need more confirmation) that most or all of the tenure track investigators in their first 2 years in several, and perhaps all, institutes were terminated. 7/n

This is very sad news!

Make a much shorter to-do list! 15 quick, simple ways to avoid overwhelm

Make a much shorter to-do list! 15 quick, simple ways to avoid overwhelm

From weightlifting to woodland walks, Guardian readers and health experts share their tried-and-tested ways to keep burnout at bay Overwhelm can come from multiple worries going round and round in our heads like a washing machine, which can deplete our…

theguardian.com

It’s amazing how humanity spent hundreds of years trying to eradicate disease from food/beverages and through vaccination to reduce child mortality and increase life expectancy & we are throwing it away in an instant. Sheer madness.

Tara C. Smith@aetiology.bsky.social · 2y ago

Raw milk, raw water. No benefits, all risk, and we're still doing this going in to 2025. I wrote about it years ago and it's still as dangerous now.

The woes of the govt are overdone. Their biggest problem is a consistent tendency to favour tactics over strategy. And failing to change the law to protect British democracy from Musk's money, is the worst example of this yet. My piece for the i. inews.co.uk/opinion/dona...

Donald Trump and Elon Musk will unite British politics - against them

We are primed for manipulation

inews.co.uk

Wishing everyone a very Merry Christmas/Happy holidays!🎄

Thou shalt pay Amazon workers fairly, for they are as close as it gets to being Santa’s elves. Without them, Christmas doesn’t happen.

A neurologist with 2 APOE4 copies tells us about his experience with #Alzheimers disease washingtonpost.com/wellness/202...

PNS2025 meeting for the first time will include a consortium dedicated to nerve injury & repair. Please submit abstracts on all aspects of nerve repair including #axondegeneration #axonregenration #immunecells #repairschwanncells #translation #surgicalrepair pnsociety.com/2025-pns-cal...

2025 PNS Call for Abstracts - Submission Deadline Extended - pnsociety.com

pnsociety.com

I know it's not Friday but I just want to revisit this because look at this beautiful painting I was given by artist @ab-etc.bsky.social - the photo doesn't do it justice but it is called Thalamus Poppies (I would add a heart emoji but they don't seem to be working). Thank you Anne!

Cathy Abbott@cathyabbott.bsky.social · 2y ago

I've never done #FluorescenceFriday before but here goes. eEF1A2 in red staining neuronal cell bodies, eEF1A1 in green, mostly in axons. I mostly love it because it looks like a field of poppies though.

Finally! We’re still waiting on Monklab to migrate over too!

Coleman Lab@colemanlab.bsky.social · 2y ago

Welcome to BlueSky @lyons-lab.bsky.social

What is or is not #Neuroinflammation 🧵? Please share your thoughts & perspectives! This article is an excellent example of a well-considered viewpoint in a broad dialogue that the Journal of Neuroinflammation wishes to have with #neuroscience #neuroskyence #immunosky #neurodegeneration communities

Eduardo Zimmer@erzimmer.bsky.social · 2y ago

What does neuroinflammation mean? Food for thought to advance the field 👇👇👇👇 journals.sagepub.com/doi/10.1177/...

Paradigm shift

KP Upadhyayula@kp11studios.bsky.social · 2y ago

This is, technically, a sandwich.

👏 to Tetsuo Hasegawa & others of Clatworthy lab & beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch www.nature.com/articles/s41...

Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge - Nature Immunology

Why joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vas...

nature.com

1/ We're experiencing a huge influx of users, and with that, a predictable uptick in harmful content posted to the network. As a result, for some very high-severity policy areas like child safety, we recently made some short-term moderation choices to prioritize recall over precision.

'Skeetorial' of our latest paper: link.springer.com/article/10.1... So proud of first author Christina Antoniou for this, now a postdoc with @melissa-gammons1.bsky.social. (1) NMNAT2 is a repressor of SARM1 NADase in axons. A few people have NMNAT2 LoF mutations. Many more have low expression.

Sign of the times, no more bluebird on the biorxiv engagement tab..

I second this. Great meeting - great friends and great science. Thanks @myelincentric.bsky.social @axoglia.bsky.social and Tanya Kuhlmann Also thanks @juliae.bsky.social for the whiskey!

Julia Edgar@juliae.bsky.social · 2y ago

The Myelin Network meeting in Kassel was simply terrific! Thanks to the organisers @myelincentric.bsky.social @axoglia.bsky.social @Tanya Kuhlmann. Exciting science and excellent socialising.

Interested in a PhD or MS in Neuroscience? PhD applications are due Dec 1st! No GREs We value and welcome diversity! Apply to @AlbanyMed! 👇 #NeuroPhD #phdlife #NeurosciencePHD

SARM1 Activation Promotes Axonal Degeneration Via a Two-Step Liquid-to-Solid Phase Transition https://www.biorxiv.org/content/10.1101/2024.11.19.624255v1

SARM1 Activation Promotes Axonal Degeneration Via a Two-Step Liquid-to-Solid Phase Transition https://www.biorxiv.org/content/10.1101/2024.11.19.624255v1

SARM1 protein plays a central role in axonal degeneration, a key process in many neurodegenerative d

biorxiv.org

By popular demand: the Axon Degeneration starter pack. Definitely incomplete so let me know who I missed. go.bsky.app/5BH6mBE

Axon degeneration

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