We extended the deadline! Send your abstracts for talk consideration until September 25 Registration and poster abstract submission close on October 16

Yale Center for RNA Science and Medicine@yalerna.bsky.social · last mo.

Have you heard? Registration is now open for the 2026 Yale RNA Center for Science and Medicine Retreat 👉November 6, 2026, Harkness Auditorium, Yale School of Medicine Registration link in institutional email Featuring presentations from Yale and UConn faculty and trainees We hope to see you there!

New preprint from the lab! Using a humanized mouse model, we found that a Human Accelerated Region drives heterochronic changes in craniofacial and limb development (apologies for the re-post, we needed to adjust the thread a bit): www.biorxiv.org/content/10.6...

A triptych of reviews on the transcription cycle @natrevmcb.nature.com 1️⃣ Initiation Chen & Xu 2️⃣ Elongation @camimoso.bsky.social @isaacfianu.bsky.social @adelmanlab.bsky.social 3️⃣ Termination Song et al. www.nature.com/articles/s41... www.nature.com/articles/s41... www.nature.com/articles/s41...

The Department of Neuroscience at Yale is hiring faculty members. We have 2 searches: one general (deadline Oct 15), one focused on computational neuroscience (deadline Nov 30). Apply! apply.interfolio.com/190736 & apply.interfolio.com/190740

Really timely review by @camimoso.bsky.social and @adelmanlab.bsky.social on RNAP in metazoans. I really like the idea of a RNAP having to "mature" in order to become a productive transcriptional machine. Plus it has my #1 favorite snRNP involved... www.nature.com/articles/s41...

Regulation of RNA transcript elongation in metazoans and its relevance to disease - Nature Reviews Molecular Cell Biology

This Review discusses how transcript elongation by RNA polymerase II is regulated and how obstacles such as nucleosomes are overcome. Also discussed are the roles of transcription surveillance machine...

nature.com

Postdoc in Nuclear RNA Biology at Aarhus University! Interested in mammalian nuclear RNA production and turnover? Come join Torben Heick Jensen’s team in Aarhus 🇩🇰 www.au.dk/om/stillinge...

Postdoc position in Nuclear RNA Biology - Ledig stilling på Aarhus Universitet

Ledig stilling ved RNA-biologi og -innovation, Aarhus Universitet

au.dk

📢 Calling all senior neuro postdocs: SYNAPSES brings postdocs from around the world to Yale to share their work during an in-person symposium on October 22, 2026. Apply today! Deadline Sept 3. medicine.yale.edu/neuroscience...

Excited to share our latest review on transcript elongation out now at @natrevmcb.nature.com!! It was an absolute pleasure to work on this review with @isaacfianu.bsky.social and @adelmanlab.bsky.social!

Nature Reviews Molecular Cell Biology@natrevmcb.nature.com · 2mo ago

ICYMI: New Online! Regulation of RNA transcript elongation in metazoans and its relevance to disease

📢 Attention Recent Graduates 📢 I’m hiring a Postgraduate Research Associate to join my growing team at Yale! If you’re passionate about RNA biology/Gene Regulation and are looking to gain hand-on research experience before graduate school, please consider applying! postdocs.yale.edu/posts/2026-0...

"Coordinated pre-mRNA processing at the single transcript level" by Leena P. Sen & Karla M. Neugebauer FREE till Aug. 26th at authors.elsevier.com/a/1nOvLcQbJI...

Check out our latest research, just published in Nature @nature.com @molbiolau.bsky.social @au.dk Molecular basis of polyadenylated RNA fate determination in the nucleus www.nature.com/articles/s41...

Molecular basis of polyadenylated RNA fate determination in the nucleus - Nature

Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...

nature.com

🧬🧬🧬 Join us this Wednesday, June 3rd for exciting talks from three early career chromatin/transcription researchers: Mark Geisler, @jcornwallscoones.bsky.social, and @sidujain.bsky.social! register here: us06web.zoom.us/webinar/regi...

⚡New preprint from the lab⚡: A key early checkpoint in gene expression is promoter proximal pausing of RNA polymerase II. For over 20 years, we as field have not been able to recreate pausing under realistic cellular conditions. @robertovn.bsky.social shows that ELOF1 is the missing piece.

Roberto Vázquez Núñez@robertovn.bsky.social · 4mo ago

🚨 New preprint: GATO-seq did it again! ELOF1 is the missing promoter-proximal factor that confers RNA Pol II resistance to TFIIF. Including ELOF1, DSIF, and NELF in GATO-seq reactions recapitulates promoter-proximal pausing in vitro at physiological conditions for the 1st time. tinyurl.com/ELOF1

One, perhaps two, of our postdocs are moving on to faculty positions this year (more news soon!). While they're truly irreplaceable, it does mean that we have openings for new members to join our team studying #cilia. If interested, please apply: academicpositions.harvard.edu/postings/15526

What is the role of #poison-exon in regulating splicing factors in stem cells and development? Check out new work from Nathan Leclair and Mattia Brugiolo and many others in my lab @jax.org #RNA #splicing www.biorxiv.org/content/10.6...

Yale MB&B's Karla Neugebauer and Guillermina Kubaczka have been featured in a new @natmethods.nature.com piece 🌍🔬 The article spotlights researchers bridging the molecular and planetary scales to address global health challenges. @karlaneugebauer.bsky.social www.nature.com/articles/s41...

Cell biology’s fantastic voyage to Planet Earth - Nature Methods

A nascent group of researchers sees planetary health as an urgent reason to bridge the molecular and planetary scales. This is shaping their strategies, methods, collaborations and outlook about their...

nature.com

RNA Club | April 2026 Join us as our trainees will share their latest research in RNA biology 📅Tuesday, April 14, 9:00 AM 📍Hope 103, School of Medicine Coffee & bagels provided Open to Yale and affiliated institutions

2nd call for postdoc positions in the lab. Get in touch for more information or simply apply here: mbg.au.dk/en/news-and-...

Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

mbg.au.dk

Happy to share our latest work on the previously uncharacterized splicing factor Cwc15! Importantly, all of the people who did this work are/were undergrads! S. cerevisiae Cwc15p Tunes the Spliceosome Active Site for 5' Splice Site Cleavage www.biorxiv.org/content/10.6...

Postdoc positions available in my lab in Aarhus, Denmark on 'Mammalian Nuclear RNA Production and Turnover Systems'. Please get in touch for further information or simply apply here: mbg.au.dk/en/news-and-...

Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

mbg.au.dk

Excited to share @suminkim.bsky.social and @mileshuseyin.bsky.social 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation: www.sciencedirect.com/science/arti...

Please join Andreas Ladurner and me for the GRC Chromatin Structure and Function conference to be held near Barcelona Spain from May 31-June 5! We accepting abstracts for posters and talks. The meeting is preceded by an awesome GRS. Learn more in our video below and apply www.grc.org/chromatin-st...

🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...

We've got two exciting chromatin talks coming up on Wednesday next week: @epijenatics.bsky.social from @jbuenrostro.bsky.social's lab and @ambystoma22.bsky.social! register and join us: us06web.zoom.us/webinar/regi...

🧬📄 Preprint update (v2): We added new biochemical experiments that clarify how IWS1 associates with the transcription elongation complex and further define competition between IWS1 and RECQL5. 🧪⚙️ www.biorxiv.org/content/10.1... Structural model is already available in the PDB (9MLC).

We’re excited to share our latest preprint on the mechanism of excised linear intron stabilization in yeast! This work was led by PhD student @glennli.bsky.social and was a wonderful collaboration with @maxewilkinson.bsky.social. Link: www.biorxiv.org/content/10.6... (1/4)

The Vlaming lab continues to grow! It's an exciting time in the Vlaming lab: we've just had our 2nd PhD student join, and the 3rd is joining in February. Now, we're looking to recruit a postdoc!

International Genome Dynamics course in Institut Curie-Paris (April 8-15), experimental and computational methods in multiomics,with a #TE centered session. Free registration, until Jan 15th Don’t miss it! 👉https://training.institut-curie.org/courses/Genome-Dynamics-2026 @institutcurie.bsky.social

RESEARCH PAPER: The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons By Bergfort et al., and Karla Neugebauer ➡️ https://genesdev.cshlp.org/content/40/1-2/94.full Karla Neugebauer Alexandra Bergfort Yale Center for RNA Science and Medicine #splicing

We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)