Our 💻x🧫 collaboration @saravasconcelos.bsky.social @uhnresearch.ca with ATOMS lab @utoronto.ca is out on @pnasnexus.org. We showed the correlation ⛓️ between the local variability of interstitial flow🚰 and the dimensional variability of microvessel 🪢 across different size scale in vitro. Enjoy 📖!

PNAS Nexus@pnasnexus.org · 3mo ago

In the quest to engineer large tissues for transplants, preserving flow conditions during vasculature scale-up can be tricky. A computational–experimental framework can help predict interstitial flow, allowing effective pre-vascularization. In PNAS Nexus: https://ow.ly/sja050ZzWfq

🚨 How do mechanical forces shape a developing organ? Our new #ScienceAdvances @science.org study, led by the amazing @cvagenapantoula.bsky.social, reveals a Piezo1-driven hydraulic mechanism, where mechanical cues control cell volume to guide cardiac formation ❤️🐟 🔗 www.science.org/doi/10.1126/...

Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis

Mechanical forces shape the developing heart by controlling cell volume through a Piezo1-driven hydraulic mechanism.

science.org

It was a great experience presenting 🗣️ my work on hPSC-microvessels at #EMBLCardioBiology 2026. I have learned 📝 a lot and connected 🤝 with many who shared similar interests 💡in blood vessel 🪢 and the heart🫀. Fired up 🔥 to transplant and test my microvessels now 💪🏼

Sara Nunes Vasconcelos, PhD she/her/hers🇨🇦🇧🇷@saravasconcelos.bsky.social · 9mo ago

Day 2 at #EMBLCardioBiology 2026 in Heidelberg kicked off with an inspiring session on #cardiovascular #regeneration spanning the full spectrum from fundamental basic science to clinical trials. Outstanding talks by @kasinans.bsky.social Florian Weinberger Wolfram Zimmermann@eldadtzahor.bsky.social

The #VasconcelosLab is at #TMM2025 Check out their posters and talks and come say hello if you see us!

Yesterday the whole lab went out for lunch to bid Sonia goodbye on her return to Paris soon. You will be missed! #VasconcelosLab @uhnresearch.ca @bbdc-uoft.bsky.social @mcsociety.bsky.social

We are hiring a PDF to use state-of-the-art data from single cell & spatial transcriptomics of microvessels to uncover the molecular blueprint of successful vascularization & apply findings to coach hPSC-endothelial cells to successfully vascularize grafts 👇 jobs.smartrecruiters.com/UniversityHe...

Postdoctoral Researcher

Company Description: UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 Team UHN members, UHN consists of Toronto General Hospital, Toronto Wes...

jobs.smartrecruiters.com

Big energy at this week’s Project #MaVen meeting! The meeting was a real reminder of what makes MaVen special: interdisciplinary collaboration. Whether it’s bioengineering, stem cell biology, bioethics or computational science, innovation happens at the intersections—and our community thrives there.

@kasinans.bsky.social presenting his beautiful work at the @bbdc-uoft.bsky.social scientific day. #bbdc @uhnresearch.ca

Vascular Development: What determines whether an endothelial cell becomes part of an artery, a vein or a capillary? elifesciences.org/articles/106...

3D reconstruction of a 3-day-old #zebrafish heart beating. Credit to Michael Weber (prev. @mpi-cbg.de). #ZebrafishZunday 🧪

Today we celebrated Chao’s last day with cake and laughter. She worked for 2 yrs in my lab and Mike’s lab contributing tremendously to our large animal studies-and even had twins along the way (though my campaign to name them Mike and Sara failed!). Best of luck, Chao - you will be missed!

"Genes are... the easy part" @philipcball.bsky.social argues biologists need to embrace complexity from the start, rather than beginning with oversimplified "one gene, one trait" models +1 www.cell.com/cell-systems...

Should biology put complexity first?

The dictum “Everything should be made as simple as possible, but no simpler” poses a problem for biology. How simply can it be told without doing damage to its complex nature? The answer might be foun...

cell.com

This one is very personal: I talk about our revascularization therapies and share a bit on how my experience as a #cancersurvivor is influencing my lab’s research. 1/ @uhnresearch.bsky.social @uhntoronto.bsky.social @uoft.bsky.social @bbdc.bsky.social

Stem Cell Network@stemcellnetwork.ca · 2y ago

(1/4) In recognition of #HeartMonth, join SCN’s Joanna Valsamis as she chats with biomedical engineering expert Dr. Sara Vasconcelos (University Health Network, Toronto) about cutting-edge stem cell research for heart disease—a leading cause of death and disability in Canada.

Amidst the craziness in the world right now I feel there is even more reason to celebrate: Xuetao's paper is now online! Check it out : www.cell.com/stem-cell-re... 1/3

Microvessel co-transplantation improves poor remuscularization by hiPSC-cardiomyocytes in a complex disease model of myocardial infarction and type 2 diabetes

In this article, Nunes Vasconcelos and colleagues show that co-delivery of adipose-derived microvessels and hiPSC-cardiomyocytes improves cardiomyocyte survival, graft size, and cardiac function in a ...

cell.com

Is endothelium a type of epithelium? I am @icfortunato.bsky.social & I would like to discuss this with a short🧵 focused on cell-cell junctions, specifically adherens junctions.