Naomichi Takemata
@naomichitakemata.bsky.social
Studying archaeal 3D genomes at Ritsumeikan University, Japan https://scholar.google.co.jp/citations?user=Q34_N9wAAAAJ&hl=ja#
New preprint from Dodonova lab 🔔! Capturing multiple states by cryo-EM❄️, we show for the first time how archaeal RNA Polymerase engages a nucleosome and forms direct contacts with histones! 🧬 Great work by Gabriele & a fantastic collaboration with Dina Grohmann! 🧵 www.biorxiv.org/content/10.6...
Excited to share our preprint on Ignicoccus cell divison: only the inner membrane divides, progeny cells accumulate in cell clusters and pop-out! www.biorxiv.org/content/10.6... Great work with the labs: @buzzbaum.bsky.social @curiousdina.bsky.social @anja1.bsky.social @tbharat-lab.bsky.social
The life cycle of an archaeon with multiple membranes
Many prokaryotes are diderms. They divide using an FtsZ division ring to simultaneously constrict physically coupled inner and outer membranes to form daughter cells with two membranes. Currently, onl...
biorxiv.org
We are looking for a research assistant! Come join the team: www.jobs.ac.uk/job/DSZ826/r...
Research Support Officer | Cell Biology | Dr Buzz Baum | LMB 2904 at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
jobs.ac.uk
MEIOSIN retains an intrinsic STRA8-independent activity that drives meiotic entry across vertebrate evolution https://www.biorxiv.org/content/10.64898/2026.03.04.709545v1
Applications are now being accepted for the 2027 Bacterial Cell Biology & Development GRC, June 6–11! GRS will be on June 5-6, 2027 We’ll likely be oversubscribed, so please apply early!
PAPER ALERT!!! For over 20 years, circular pre-rRNA intermediates were thought to be a specific and universal requirement for archaeal ribosome biogenesis. doi.org/10.1261/rna.... #Archaea #Ribosome #RNAProcessing #Archaeasky #RNAsky
How are mitotic chromosomes built? Our Review @cp-trendsgenetics.bsky.social revisits the classical chromosome scaffold model and connects it to condensins, topoIIα, and physical forces. We propose interphase chromatin domains as “building blocks”🧩of chromosomes: authors.elsevier.com/a/1nmwrcQbJI...
If you thought you understood how one cell becomes two (and imagined studying the problem using an organism that lives in deep sea volcanic vents was impossible), read Florian’s paper and think again!
Florian Mayer@florianmayer.bsky.social · 3w agoExcited to share our preprint on Ignicoccus cell divison: only the inner membrane divides, progeny cells accumulate in cell clusters and pop-out! www.biorxiv.org/content/10.6... Great work with the labs: @buzzbaum.bsky.social @curiousdina.bsky.social @anja1.bsky.social @tbharat-lab.bsky.social
The brilliant Kris Kuo, with help from Fabian and the Werner lab, has identified a key driver of cyclic gene expression in Sulfolobus, which has a cell cycle but no CDK/cyclins. Amazingly, TFB2 has a cyclin box that regulates its degradation as cells exit division. Another reason to love archaea!
A TFIIB paralog drives cyclic transcription to orchestrate the archaeal cell cycle
Cyclic transcription is a hallmark of the cell cycle. While transcriptional waves in eukaryotes are driven by oscillations in cyclin-dependent kinase (CDK) activity, many archaea have an ordered cell ...
biorxiv.org
Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗 www.nature.com/articles/s41... (1/2)
1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...
🇦🇺↔🇯🇵 for undergrad/masters students studying in Australia and interested in short-term research opportunities this summer (Jan 7 – Feb 18 2027) - please check out Kyoto University's KU-STAR program: www.kugd.k.kyoto-u.ac.jp/en/ku-star-p... ! Application deadline is Sep. 25, happy to take questions.
KU-STAR Program AUS
What’s the KU-STAR Program? KU-STAR Program, Kyoto University Short-Term Academic Research Pro
kugd.k.kyoto-u.ac.jp
Check out our paper on ESCRTs in large DNA viruses. Most enveloped viruses use the host #ESCRT for envelopment, but only mirusviruses and nucleocytoviricots encode it! Congrats @sonaida.bsky.social, @tomdelmont.bsky.social, Ulysse Guyet & Eugene Koonin. @pasteur.fr www.nature.com/articles/s41...
Large eukaryotic DNA viruses encode ESCRT machinery for membrane remodelling - Nature Microbiology
A genomic screen reveals homologues of ESCRT components in mirusviruses that infect unicellular aquatic eukaryotes.
nature.com
New preprint from the lab! One reason why I chose work on trypanosomes is to address this question "How do they determine kinetochore position without a centromeric histone H3 variant, CENP-A/CenH3?" After working on this question for 16 years, we finally got a clue
bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 2mo agoThe centromere localization domain of kinetoplastid kinetochore protein KKT2 recognizes the free N-terminus of histone H3 https://www.biorxiv.org/content/10.64898/2026.08.13.744621v1
Now accepted in Journal of Cell Science @jcellsci.bsky.social doi.org/10.1242/jcs....
Identification of feeding apparatus components in a heterotrophic marine flagellate
Diplonemids are highly abundant heterotrophic single-celled flagellates that are widespread in the world's ocean. They have a highly complex microtubule-based feeding apparatus (cytostome-cytopharynx ...
doi.org
Bungo Akiyoshi@bungoakiyoshi.bsky.social · 6mo agoNew preprint! We identified many components that localize to the structure involved in "eating" in a marine organism. #ProtistOnSky #diplonemid www.biorxiv.org/content/10.6...
Now published in JBac. Absolutely great publishing experience!!! Thank you to editors and reviewers.https://journals.asm.org/doi/10.1128/jb.00286-26 Another great one from @tommclean.bsky.social @johninnescentre.bsky.social @hbio-isp.bsky.social
TrbA binds and locks a sliding clamp KorB to repress transcription on multi-drug resistance plasmids | Journal of Bacteriology
Precise regulation of gene expression ensures gene products are produced at the right time and in the right amounts. Recent works uncovered a new mechanism of bacterial gene regulation based on a clamp sliding and locking in a multi-drug resistance plasmid, RK2. KorB functions as a CTP-dependent DNA-sliding clamp capable of traveling over a long genomic distance. Sliding KorB is captured and locked in place by a partner protein, KorA, forming a stable complex at target promoters to repress transcription. Here, we show that another RK2 regulator, TrbA, also uses this clamp sliding-locking mechanism, and identify an aromatic interface enabling TrbA-KorB-mediated transcriptional repression. Our findings show how a single sliding clamp integrates multiple partners to build a complex transcriptional regulatory network.
journals.asm.org
Tung Le@tunglejic.bsky.social · 4mo agoHere, @tommclean.bsky.social shows that another RK2 regulator, TrbA, likely also use this “clamp sliding-locking” mechanism to regulate gene expression. Interesting how a single sliding clamp might integrate multiple partners to potentially build a complex regulatory network... shorturl.at/YQJOI
The Sasaki lab at the National Institute of Genetics in Japan are seeking for highly motivated PhD students to work on extrachromosomal circular DNA, gene amplification, genome stability, and cancer genome dynamics, starting in October 2027. Please see below and apply by August 31.
Hot, acidic and an endlessly fascinating archaeal model organism! Check out our review on Sulfolobus acidocaldarius🥳
Marleen van Wolferen @marleenvw.bsky.social · 2mo agoWith the 50th anniversary of #Archaea research coming up, read our latest review on one of its defining (and my favorite) model organisms: Sulfolobus acidocaldarius. #ArchaeaSky @archaellum.bsky.social, @sshamphavi.bsky.social, @michaelspaedt.bsky.social journals.asm.org/doi/10.1128/...
Our latest publication is on bioRχiv! — a study of the meiotic double-strand break machinery, focused on C. elegans but using the extensive genomic resources available for the whole genus to learn more about how SPO-11 and its cofactors work together to break DNA www.biorxiv.org/content/10.6...
Multifaceted and evolutionarily dynamic interactions between Caenorhabditis elegans SPO-11 and its cofactors ensure proper formation of meiotic DNA double-strand breaks
DNA double-strand breaks (DSBs) generated during meiotic prophase by the topoisomerase-like protein SPO11 are essential to create crossovers between homologous chromosomes. Since crossovers are requir...
biorxiv.org
Bacteriocins in archaea and archaeocins in bacteria. @romainstrock.bsky.social surveys the the exchange of molecular weaponry between archaea and bacteria. www.biorxiv.org/content/10.6...
Bacteriocins in archaea and archaeocins in bacteria
Archaea and bacteria routinely live side by side in microbial communities and must interact at least on occasion. Whether such cross-Domain interactions are dominated by mutual disregard, co-operation...
biorxiv.org
Archaeaophiles! Last chance to sign up as a virtual attendee for MBoA2026. It’s cheap and you will have access to all the talks include our archaea@50 celebration with a special guest: meetings.embo.org/event/26-arc...
Molecular Biology of Archaea: Life Through the Prism of Archaea
In 1977, Woese and colleagues revealed Archaea as a distinct domain of life. Building on this insight, the discovery of Asgard archaea has strengthened the view that many hallmarks of eukaryotic cell…
meetings.embo.org
Excited to be part of this fantastic project!
Svetlana Dodonova@dodonova-sveta.bsky.social · 4mo agoExcited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...
Archaea are the hornets of the microbial world. Discuss. www.biorxiv.org/content/10.6... TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
biorxiv.org
now published!!! @johninnescentre.bsky.social @leahmcphillips.bsky.social academic.oup.com/nar/article/...
Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems
Abstract. Low-copy-number plasmids often rely on dedicated maintenance mechanisms, such as partitioning systems, to ensure stable inheritance across genera
academic.oup.com
New preprint! Cell division has to happen at the right place but how Archaea pick that place is unknown. We now identified a three-protein system, Dip, that positions the divisome at midcell in H. volcanii and is broadly conserved across Archaea. A thread 🧵 www.biorxiv.org/content/10.6...
biorxiv.org
The Bisson Lab at IU (bissonlab.com) is hiring makers/builders/engineers across all career stages to join our team in one of the most exciting and crazy projects I've set to work on. Candidates can email us: saltylab@iu.edu More info in the thread [1/3]
how does loop extrusion and chromatid cohesion interact in interphase? Find out in our latest collaboration with Gerlich lab | | | vvv
Gerlich Lab@gerlichlab.bsky.social · 5mo agoNew preprint out!🧬 How do cells keep replicated sister chromatids linked for DNA repair while folding 3D loops for gene expression? Extrusion folds DNA but separates sisters, while cohesion connects them, risking mutual interference. How do they coexist?🧵👇 🔗 doi.org/10.64898/2026.05.02.722390 1/6
New preprint alert! Together with Tetsuya Yamamoto at Hokkaido University, we propose a “polymer micelle” model of transcriptional bursting. www.biorxiv.org/content/10.6...
