We all learnt from each other and it was real pleasure working together to understand GAPMs in plasmodium.

Clinton Lau@ckylau.bsky.social · 5mo ago

We look into whether the three GAPMs work together or separately, and look at whether their localisation and binding partners changes in different life cycle stages. I'm immensely proud of this work, led by Akancha Mishra from @ritatewari.bsky.social's lab and Giedre Ratkeviciute from ours.

New preprint! Really excited to share our spatial proteomic study on Plasmodium falciparum schizonts . We used hyperLOPIT to map thousands of proteins—from apical invasion organelles to the infected red blood cell surface.

Ross Waller@rosswaller.bsky.social · 9mo ago

Excited to release the Herculean efforts of @scottchisholm.bsky.social &Co. defining the subcellular #hyperLOPIT spatial proteome of #Plasmodium schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified. www.biorxiv.org/content/10.1...

A huge thank you to all my co-authors for this great collaboration! @ritatewari.bsky.social @davidguttery.bsky.social @zeeshanm.bsky.social @eelcotromer.bsky.social

“The idea that taking walks, reading things unrelated to your research, and hanging out with strangers in a campus pub should be considered part of the serious process of thinking, but might well meet with skepticism in practice.” www.pnas.org/doi/10.1073/...

The forgotten half of scientific thinking | PNAS

The forgotten half of scientific thinking

pnas.org

Many congratulations Ryuji. Your first paper on Plasmodium biology. Well done.

Ryuji Yanase@ryanase.bsky.social · last yr.

Excited to share our publication @lsajournal.org showing that divergent Plasmodium kinases drive MTOC, kinetochore and axoneme organisation during male gamete formation. Many thanks, @ritatewari.bsky.social, @davidguttery.bsky.social, @zeeshanm.bsky.social, Tony and David F. doi.org/10.26508/lsa...

Happy Holi from our lab. Festival of colours. This to welcome the spring which I hope is round the corner.

📸 No one follows more etiquette rules than the Royal Family—but notice how King Charles didn’t make any smart-ass or demeaning comments about Zelensky’s attire today. Why? Because respect isn’t about clothes—it’s about character. And that’s something money can’t buy.

The Nikon AX-NSPARC demo is gearing up at the @ncis-marseille.bsky.social! Starting for #FluorescenceFriday with a large field-of-view confocal #cellfie of COS cells labeled for actin ⚫ endoplasmic reticulum 🟡 mitochondria 🔴 and nucleus 🔵. Fluorescence microscopy is also nice in inverted colors 🌈🧪

The world is full of crazy and sad news, but here is a protein that localizes to only one of the two flagella

Plastids & mitochondria arose from separate endosymbioses of prokaryotes.Their prokaryotic ancestry makes them susceptible to antibiotics. Antibiotics kill pathogenic protists by targeting their plastids or mitochondria. Here we review the lop sided inheritance. journals.plos.org/plospathogen...

Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists

Pathogenic protists are responsible for many diseases that significantly impact human and animal health across the globe. Almost all protists possess mitochondria or mitochondrion-related organelles, ...

journals.plos.org

The next GRC on volume Electron Microscopy is coming soon. Don't miss this opportunity and apply now as the number of seats is limited. #volumeEM www.grc.org/volume-elect... As I am new to bsky, please share widely (do we still say retweet?). 🙏

Many congratulations Richard and team. Great story on DNA replication.

Richard McCulloch@rmc9z.bsky.social · 2y ago

New paper @uofgsii.bsky.social led by @scotomorph.bsky.social @marquescata.bsky.social where we show that T. brucei DNA replication dynamics reflect structural and functional compartmentalisation of the genome, including stability. Well done Marija, and thanks all co-authors! doi.org/10.1038/s414...

A couple of weeks left to apply to join Development's *Pathway to Independence* programme Support & mentoring for post-docs on the academic job market Deadline: January 31 journals.biologists.com/dev/pages/pi...

What started out as chromosome-counting blossomed into an exciting tale of evolution at the interface between the volatile centromere and the reliable, stable cell division machinery - the latest from the brilliant Jana Helsen, now looking to start her own group! W/ @gsherloc.bsky.social 🧪🌎

Jana Helsen@helsenjana.bsky.social · 2y ago

Centromere evolution isn't a sudden switch! Our study shows centromere transitions are a step-by-step process driven by a combination of drift and selection. Discover how the kinetochore interface shapes this gradual change in our new preprint 🥳 doi.org/10.1101/2025.01.16.633479 🧵(1/8)

If you’re thinking of what meeting to go to this year then check out the #phosphatase meeting in Würzburg. Lots of great speaking slots and events for junior researchers. It’s always a fun meeting meetings.embo.org/event/25-pho...

Phosphatases: from basic research to translation

Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…

meetings.embo.org

New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today: SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion! www.sciencedirect.com/science/arti... 1/

DNA replication beyond the cores of megabase chromosomes of T. brucei -- some of my PhD work is FINALLY out! doi.org/10.1038/s414... thank you to @rmc9z.bsky.social @marquescata.bsky.social Emma, Dario, Kathryn, Graham and Craig!

Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei - Nature Communications

A full description of trypanosome genome replication has proved elusive. Here, after genome assembly, the authors reveal compartmentalisation of DNA replication activity and stability between transcri...

doi.org

Delighted to share our first manuscript on @bsky.app on a novel SUN1-ALLAN complex in Plasmodium MTOC and NE organization. Many thanks @zeeshanm.bsky.social; @eelcotromer.bsky.social; @ryanase.bsky.social ; Tony; Sarah; David F; Karine; Igor; Cyrille; Declan. Link: www.biorxiv.org/content/10.1...

Here we are! To celebrate our arrival, here is a #trypanosome expanded ~13 times & stained for tubulin, individual cortical #microtubules can be recognised, what was only achievable by EM before. Images: Christine Girard-Blanc & Thierry Blisnick. Many thanks to @centriolelab.bsky.social for training

"Any pleasure I may take in the distinction of [being a Royal Society fellow] is diminished by the fact it is shared with someone who appears to be modelling himself on a Bond villain" www.researchprofessionalnews.com/rr-news-uk-c...

Royal Society fellow resigns over Elon Musk membership - Research Professional News

Dorothy Bishop lambasts world’s oldest scientific academy as she quits in protest

researchprofessionalnews.com

Cryptosporidium is an important public health threat, and it deserves better genetic tools to study it! Here we’ve developed a targeted in vivo CRISPR genetic screen to identify parasite genes required for survival and virulence… www.biorxiv.org/content/10.1...

I like this plan from EupathDB - No paywall 😀. We can volunteer to pay a fee from lab budgets. And a "mortgage calculator" tool coming up in Jan to guide us estimate that fair price based on several variables like lab size and usage. youtu.be/aSS6fiGVBG4?...

Parasitology Community Meeting

YouTube video by VEuPathDB

youtu.be

"Given the current political reality and the expansion of attacks on science, it is time for scientists to be more effective, forceful, and vociferous as their own political advocates." 🧪 www.science.org/doi/10.1126/...

Scientists as political advocates

Science, both teaching and doing, is under attack. The recent US presidential election of a person and platform with anti-science bias exemplifies this. The study of climate processes and patterns and...

science.org

Check out our new paper showing that male gametocytes need an active mitochondrion for gametogenesis: www.nature.com/articles/s42... Also, we have a big plug for our excellent new antibody marker specific for male gametocytes and gametes. @lshtm.bsky.social🧵

Mitochondrial ATP synthesis is essential for efficient gametogenesis in Plasmodium falciparum - Communications Biology

Male gametocytes rely on mitochondrial ATP to fuel gametogenesis in Plasmodium falciparum.

nature.com

New preprint from others in the lab - Mapping origins of DNA replication in Leishmania. Great work Jeziel, Gabriel, @marquescata.bsky.social, Marija, Craig, Dario and the boss! www.biorxiv.org/content/10.1...

Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events

Understanding genome duplication requires characterisation of the locations where DNA replication initiates, termed origins. Genome-wide mapping of DNA replication origins has mainly been derived from...

biorxiv.org

Only two weeks to go to the UK Vector-Borne Diseases meeting in Liverpool (3-4th December). We are full and there is no further registration for in-person attendance. Therefore, we have opened up online attendance - see here if interested. @baylism.bsky.social payments.liv.ac.uk/conferences-...

New preprint! How do cells rewire chromosome segregation during meiosis? We identify a germline-specific mRNA splice isoform for a critical kinetochore protein. This alternative protein transforms its regulatory control, contributing to proper fertility. www.biorxiv.org/content/10.1...

Official website for EMBO meiosis 2025 is live now! Looking forward to seeing you in Switzerland next June! #meiosis4eva meetings.embo.org/event/25-mei...

Meiosis: Exploring diversity to discover the fundamentals

Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …

meetings.embo.org