I am honored. So many of my scientific heroes are ASCB fellows. Thanks to my nominators, my mentors, and to UC Davis ASCB fellows Mark Winey, Jon Scholey, and Jodi Nunnari. But thanks most to all those who have done science with me, @gwgl.bsky.social and all the graduate students and postdocs

American Society for Cell Biology@ascbiology.bsky.social · 2d ago

Congratulations to the 2026 ASCB Fellows! ASCB is proud to recognize 15 scientists whose careers have advanced cell biology through outstanding research, leadership, mentorship & service. Meet the 2026 Fellows: https://www.ascb.org/society-news/fifteen-visionary-scientists-named-2026-ascb-fellows/

One cell, one tomogram! Our montage tomography workflow, MOSAIC, is out in Structure, and MontageMaker is on GitHub! MOSAIC: www.cell.com/structure/fu... MontageMaker: github.com/MPI-Dortmund... Big thanks to @maikaboiero.bsky.social, Adriana Prajica, Gavin Rice, and @raunser-lab.bsky.social!

This story is now published in @natplants.nature.com ! 🎉🎩 Check out the final article here: nature.com/articles/s41477-026-02361-1 Very similar to the original bioRxiv preprint, with the addition of some cool polysome analysis (in the supplementals)! Thanks and congrats to everyone involved! 🙏

Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome - Nature Plants

Using in situ cryo-electron tomography, researchers found a unique ‘arm’ domain on the small subunit of Chlamydomonas chlororibosomes. This discovery suggests that chlororibosome structure is more evo...

nature.com

Florent Waltz@florentwaltz.bsky.social · 6mo ago

Long in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖: shorturl.at/q44tG This suggests greater chlororibosome diversity than expected! 1/n 🧵

www.science.org/doi/10.1126/...

Eukaryotic-like microtubules and dynamic instability of Asgard archaeal tubulins

Asgard archaeal mini microtubules suggest an archaeal origin of eukaryotic microtubules.

science.org

#TubulinTuesday!

Cell Biology J-Club@cellclub.bsky.social · 3w ago

Structural basis of kinesin-1 autoinhibition and its control of microtubule-based motility | Science Advances www.science.org/doi/10.1126/...

The mitochondria are the powerhouse of the cell — and according to biologist Martin Picard, they’re also the link between biology, health, and the mind. In other words, the foundation of our experience being alive. www.quantamagazine.org/martin-picar...

Martin Picard’s Mitochondrial Theory of Mind | Quanta Magazine

The biologist’s bold “energetic view of life” looks to the body’s strangest organelles as the link between cells, health, and mind and the foundation of our experience of being alive.

quantamagazine.org

I'm excited to announce a new preprint from the lab just posted to bioRxiv: “Retrograde trafficking inhibitors allosterically trap Get3 to block tail-anchored protein biogenesis.” www.biorxiv.org/content/10.6...

How do 2 meters of DNA fit inside a nucleus you can barely see? 🧬 Our new study mapped individual nucleosomes inside human cells.

Excited to share my paper! 🥳 Today in #Nature we reveal an 8 MDa Hdr electron bifurcating super-assembly in class I methanogens that couples the first and last steps of hydrogenotrophic methanogenesis. A lineage-specific adaptation to anaerobic niches. www.nature.com/articles/s41...

1/ Happy to share our preprint! The Mtr complex catalyses the second-to-last step of the methanogenesis and is an essential bioenergetic machine in most methanogenic archaea. Anaerobic cryo-EM of Mtr reveals a nitrogenase-like metallocluster bound at its active site! www.biorxiv.org/content/10.6...

CryoSPARC workshop in Toronto! Beyond consensus refinements: Advanced cryo-EM data processing with CryoSPARC Sept 24-25, 2026 (part of the Canadian Cryo-EM Nexus) Register here: cvent.me/dL1wem Please see details in the link or the image Alt text @structurabio.bsky.social @sickkidsto.bsky.social

“The Website” is here! It can be intimidating getting into analysis of #CryoET data, and software is evolving all the time👩‍💻🚀. @phaips.vd.st & @florentwaltz.bsky.social put our lab’s workflows into an online guide. We hope this helps lower the bar to joining #TeamTomo. Feedback much appreciated! 🧪🧶🧬🔬

Philippe Van der Stappen@phaips.vd.st · last yr.

Hey #TeamTomo, Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging? That's why @florentwaltz.bsky.social and I made this website! tomoguide.github.io Follow the thread 1 /🧵 #CryoET #CryoEM 🔬🧪

How did complex cells emerge? In this groundbreaking paper, @tonigabaldon.bsky.social & co show that eukaryotes arose through multiple waves of ancient genetic exchange involving diverse bacteria (& giant viruses!) revealing a far more complex origin than we imagined. www.nature.com/articles/s41...

Exciting work from the Maldonado lab (formerly of @ucdavis.bsky.social , now at @monashuniversity.bsky.social) The first structure of Photosystem I from giant kelp! www.monash.edu/news/article...

New research suggests giant kelp could inspire innovative climate solutions

New research reveals the microscopic machinery that helps giant kelp turn sunlight into energy, providing inspiration for innovative new climate solutions.

monash.edu

We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇

Nature research paper: Early fossil eukaryotes were benthic aerobes go.nature.com/3Rdw9rk

Early fossil eukaryotes were benthic aerobes - Nature

Integrated palaeontological, sedimentological and geochemical analyses of ancient rocks from Australia show that early eukaryotes were largely restricted to oxygenated benthic habitats, probably possessed mitochondria by 1.75 billion years ago, and may have expanded into planktonic habitats much later, perhaps during the Neoproterozoic era.

go.nature.com

🔔Our latest special issue, guest edited by Dr. Panagiotis L. Kastritis, is now live! 🧊 Eight reviews explore the role of cryo-EM in understanding diverse complexes, painting a picture of a field moving toward greater understanding of metabolic architecture. ❄️ tinyurl.com/FEBSCryoEM

cryosparc-tools is a standalone Python library that connects to #CryoSPARC and is designed to advance your #cryoEM data processing via scripting. 🚀 Watch this new video for an overview of cryosparc-tools, and explore the resources linked in the description 👉 youtu.be/QY7t67c9bQ8

CryoSPARC Tools: Simple scripting for advanced cryo-EM processing

YouTube video by Structura Biotechnology Inc.

youtu.be

And now it's out! Happy that PNAS selected for the cover this SEM image snapped by @samjlord.bsky.social, one of the most evocative visualizations of Euplotes that I have ever encountered. www.pnas.org/doi/10.1073/... Stay tuned for what is shaping up to be some fascinating follow-up in the lab...

Ben Larson@blarson.bsky.social · 11mo ago

What could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells? www.biorxiv.org/content/10.1... Video by Vittorio Boscaro. 1/n

Our story on RNA recognition by Egl-BicD is now published! Also delighted to share the accompanying News & Views article by Florence Besse and Andres Ramos, which beautifully highlights the work. Paper: www.nature.com/articles/s41... News & Views: www.nature.com/articles/s41...

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 3mo ago

The hidden rules behind mRNA transport. A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs. Read more: mrclmb.ac.uk/news-events/... #LMBNews @cellbiol-mrclmb.bsky.social 🧪

The hidden rules behind mRNA transport. A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs. Read more: mrclmb.ac.uk/news-events/... #LMBNews @cellbiol-mrclmb.bsky.social 🧪

Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)

If you're in the Milwaukee area (including Chicago...), come visit the models! When teachers aren't here for summer workshops, they get so lonely... And you must talk to them. Tell them they are pretty models, and good models. (Just ask for a tour at 3dmoleculardesigns.com/contact-us) #3dThursday

How do cells convert mechanical information into a molecular process? The @alushinlab.bsky.social has captured the first snapshot of a mechanical signaling complex in action, findings in @nature.com that have implications for disorders related to myosin dysfunction. 🔗: https://bit.ly/41Kshjw

Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.

Are you looking for a training course that will provide you with an introduction to cryoEM and its applications in structural biology ? Then join us in July! 📆 Tues 7 Jul, 9:30-16:30, University of Leicester Book your place: my.rsb.org.uk/item.php?eve... #Training #CryoEM

Our paper on the proton-driven secondary active #transporter SbmA for antimicrobial peptides is finally out! We used #cryoEM, #EPR, #MD to show that it resembles and undergoes conformational changes like #ABC transporter TMDs consistent with an alternating-access transport mechanism.

Chancie T@chanciet.bsky.social · last yr.

Check out our new preprint on the bacterial secondary active #transporter SbmA.

Across scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬 Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social

Tomas Pascoa@tomaspascoa.bsky.social · 4mo ago

1/ Excited to share our preprint! 🥳 Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine www.biorxiv.org/content/10.6...

New #ISEPpapers #preprint by @deemteam.bsky.social: Re-evaluating the eukaryotic Tree of Life with independent phylogenomic data www.biorxiv.org/content/10.6... #Protists #Microbes #Evolution #Eukaryotes #TreeOfLife #Phylogeny #Phylogenomics #Bioinformatics #Algae

How do “LEGO-like” electron-bifurcating modules combine to drive degradation in BTEX-contaminated ecosystems? Check out our latest preprint, where we use cryo-EM and cryo-ET to reveal how the 1 MDa BCRII complex powers extremely endergonic aromatic ring reduction. www.biorxiv.org/content/10.6...