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Sristi

@sristi.bsky.social

One thought at a time, ten stops deep.. #DevelopmentalBiology #CellBiology #mechanobiology Student@KanazawaUniversity @preLights.bsky.social

13 Posts898 Follower589 Folgt
preLights@prelights.bsky.social · 4mo ago

Exciting #preprints in nuclear cell biology. As part of the latest Special Issue in @jcellsci.bsky.social, this article bundles together relevant #preLights. preLighters involved include @pierrecaron.bsky.social, Abby, Reinier @sristi.bsky.social & Filipe journals.biologists.com/jcs/article/...

Preprint highlights in nuclear cell biology

This article features recent preLights that discuss preprints relevant to this ‘Cell Biology of the Nucleus’ special issue.preLighterPierre Caron, CNRS researcher at the Institute of Structural Biolog...

journals.biologists.com

preLights@prelights.bsky.social · 12mo ago

Do you love the monthly #preprint lists on @the-node.bsky.social? Good news, our #preLighters have teamed up with the Node to nominate standout articles and share one-paragraph insights on why they’re excited. Check out their October highlights ⬇️ 👀 thenode.biologists.com/prelighters-...

preLighters’ choice - October’s handpicked preprints - the Node

Concise preprint highlights from the October preprint list, prepared by the preLighter community. Quick reads from early-career researchers to help working scientists spot the month’s most exciting bi...

thenode.biologists.com

the Node@the-node.bsky.social · 12mo ago

You must have been looking forward to... October in preprints! Check out the latest #preprints on #DevBio, #StemCell biology and related topics with, starting this month, @prelights.bsky.social picks 👇👀 thenode.biologists.com/october-in-p...

Kate Cavanaugh@katecavanaugh.bsky.social · last yr.

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

Sara Wickstrom@sarawickstrom.bsky.social · last yr.

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

nature.com

Akankshi Munjal@akankshi.bsky.social · last yr.

Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd

@sameerthukral.bsky.social · last yr.

Excited to share our new review in Development, Growth and Differentiation(DGD) Journall! With the amazing @yuchiunwang.bsky.social & @bipashadey29.bsky.social,we explore how rigidity transitions bridge cytoplasmic & tissue scales. Read the full review: onlinelibrary.wiley.com/doi/full/10....

Integrating Tissue and Cytoplasmic Rigidity Transitions During Morphogenesis

Multicellular organisms generate organizational complexity through morphogenesis, in which mechanical forces orchestrate the movements and deformations of cells and tissues, while chemical signals re...

onlinelibrary.wiley.com

preLights@prelights.bsky.social · last yr.

Cancer cells that survive, thrive: capillary constrictions as a trigger of mechanotransduction in cancer progression. Check out this #preLight by Sristilekha Nath, which talks about the work by @gsilvani.bsky.social, @kriskilian.bsky.social and the team.

Capillary constrictions prime cancer cell tumorigenicity through PIEZO1 - preLights

Cancer cells that survive, thrive: capillary constrictions as a trigger of mechanotransduction in cancer progression

prelights.biologists.com

James Briscoe@jamesbriscoe.bsky.social · last yr.

A Summer reading recommendation: new primer in @dev-journal.bsky.social explains how dynamical systems theory unlocks the logic of developmental patterning Everything from bistable switches & oscillators to phase portraits & more with Python code to explore journals.biologists.com/dev/article/...

From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms

Summary: Dynamical systems theory provides a powerful quantitative and intuitive framework to understand developmental processes. This Primer brings key concepts of this framework to the ever-growing ...

journals.biologists.com

Peter O'Toole@yorkbioimaging.bsky.social · 2y ago

CellPhePy is now available 🎉🎉🎉 in the journal of #microscopy. A python version for #CellPhe. See doi.org/10.1111/jmi.... Thanks @ukri.org and @wellcometrust.bsky.social for funding @globias.bsky.social @globalbioimaging.bsky.social @eurobioimaging.bsky.social @bioimaginguk.bsky.social

CellPhePy: A python implementation of the CellPhe toolkit for automated cell phenotyping from microscopy time‐lapse videos

We previously developed the CellPhe toolkit, an open-source R package for automated cell phenotyping from ptychography time-lapse videos. To align with the growing adoption of python-based image anal...

doi.org

Claire Dessalles@clairedessalles.bsky.social · 2y ago

Very happy and excited to share our latest work linking actin nematodynamics and endothelial cell mechanics under anisotropic tension, now published in @natphys.nature.com ! rdcu.be/eigWi @ipparis.bsky.social @polytechniqueparis.bsky.social

Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics

Nature Physics - Blood flow through a vessel deforms vessel walls. Cells lining these walls sense the changes in pressure as blood flows and reorient their actin fibres in the direction of largest...

rdcu.be

Thibaut Brunet@thibautbrunet.bsky.social · 2y ago

Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...

Tissue-like multicellular development triggered by mechanical compression in archaea

The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...

science.org

Eszter Posfai@eposfai.bsky.social · 2y ago

A duo of preprints on the dynamics of the first cell fate decision in mouse by Madeleine Chalifoux (first grad student in the lab!) and Maria Avdeeva (Flatiron). We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.

preLights@prelights.bsky.social · 2y ago

Check out our latest podcast episode ( #spotLights ) in which we talk to the creator of #tidyplots: Jan Broder Engler🎙 Ep. 7 🎧: www.youtube.com/watch?v=o0kl... Also, please take a look at the related #preLights post prepared by Felipe Del Valle Batalla: prelights.biologists.com/highlights/t...

spotLights Ep 7: preLights in conversation with Jan Broder Engler

YouTube video by The Company of Biologists

youtube.com

Jan Broder Engler@jbengler.de · 2y ago

New @prelights.bsky.social podcast episode about the story behind #tidyplots 🎙 Thanks to @ethanewe.bsky.social, Shreya Pramanik and @fadelvalle.bsky.social 🙏 www.youtube.com/watch?v=o0kl... #rstats #dataviz #phd

Erdinc Sezgin@sciezgin.bsky.social · 2y ago

New paper out 🎇 It has been 13 years since @owenlabuob.bsky.social and co. published a stellar protocol on how to measure membrane order with smart probes! Since then, there has been new dyes, imaging modes and biology! We wrote a protocol for Nature Protocols: www.nature.com/articles/s41...

Measuring plasma membrane fluidity using confocal microscopy - Nature Protocols

Membrane fluidity is a crucial feature in understanding cellular physiology. This protocol describes a robust pipeline for measuring plasma membrane fluidity using confocal imaging and new environment...

nature.com

Dave Barry@david-j-barry.bsky.social · 2y ago

Here it is, in collaboration with @lankylaste.bsky.social, Lina Gerontogianni & Gavin Kelly: www.biorxiv.org/content/10.1... * Stats tests often used inappropriately * Masses of data points are often unnecessary * Inferring biological significance almost impossible without appropriate controls

Enhancing Reproducibility Through Bioimage Analysis: The Significance of Effect Sizes and Controls

Bioimage analysis is a powerful tool for investigating complex biological processes, but its robustness depends on both technical precision and rigorous experimental design. In particular, the use of ...

biorxiv.org

Dave Barry@david-j-barry.bsky.social · 2y ago

New preprint coming soon, discussing issues around inappropriate use of statistics and controls in #BioImageAnalysis and providing guidelines. But here's a teaser: more data doesn't necessarily mean more information - the law of diminishing returns can kick in surprisingly early.

the Node@the-node.bsky.social · 2y ago

Deforming Nuclei: a way to move through the crowd! Read this #BehindthePaper story from Mariana Maia-Gil about the work @nordenlab.bsky.social, looking into how nuclear properties influence nuclear positioning in the densely packed🐟retinal neuroepithelium: thenode.biologists.com/deforming-nu...

Deforming Nuclei: a way to move through the crowd! - the Node

In their recent paper, Maia-Gil and colleagues explored whether and how nuclear properties can influence nuclear positioning in vivo. Their work revealed

thenode.biologists.com