www.nature.com/articles/s41... Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy - Nature

Acetyl-coenzyme A functions as a non-canonical signal to trigger mitophagy, and the acetyl-coenzyme A–NLRX1 axis underlies the KRAS-inhibitor-induced mitophagy response and promotes drug resistan...

nature.com

A game changer in our hands... www.nature.com/articles/s41...

Universal consensus 3D segmentation of cells from 2D segmented stacks - Nature Methods

u-Segment3D is a universal framework that translates and enhances 2D instance segmentations to a 3D consensus instance segmentation without training data. It performs well across diverse datasets, inc...

nature.com

Thrilled to announce the launch of my lab @cri-utsw.bsky.social at UTSW this January! We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.

Children's Research Institute at UT Southwestern@cri-utsw.bsky.social · 10mo ago

We're growing! Our newest Investigator @henrydebelly.bsky.social will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ cri.utsw.edu/faculty/henr... and 📌apply to research in his lab cri.utsw.edu/careers

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...

Cell-surface DNA - wowser! 🧬❤️

Ryan Flynn@raflynn5.bsky.social · 10mo ago

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues. www.biorxiv.org/content/10.1...

#Micorscopy community, does anyone know where I can order this type of bottle from? Or even what the proper name is for them?

Our new paper, in collaboration with Bristol Myers Squibb, on a Natural Killer cell immune therapy, is just published here: www.pnas.org/doi/10.1073/... #immunesynapse #nkcells #immunetherapy #microscopy

Nanoscale restructuring of the immune synapse with an engager enhances NK cell function | PNAS

Engagers are antibody-based therapies which bind immune cell receptors and a target cell ligand. Next-gen engagers typically bind two activating re...

pnas.org

Check out this excellent paper from Khodor Hazime and @dandavis101.bsky.social! It's got NK cells, it's got engagers, plus super-resolution microscopy!

Olatz Niembro@olatznv.bsky.social · 11mo ago

Our new paper is out! Khodor Hazime led the brilliant work at the @dandavis101.bsky.social lab that shows *how* engagers that bring NK cell receptors together at the immune synapse boost activation against tumour cells www.pnas.org/doi/10.1073/...

'Novartis is buying the rights to potential cardiovascular medicines from a Chinese biotech in a deal worth up to $5.2bn, as big pharmaceutical companies become increasingly reliant on Chinese innovation to replenish their drug pipelines.'

Novartis strikes deal worth up to $5.2bn for Chinese cardio drug rights

Argo Biopharma collaboration adds to record total this year spent by big pharma on treatments from Chinese companies

ft.com

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

This is such a great work! Congratulations to everyone 🥳🥳🥳

Christian Frezza@frezzalab.bsky.social · 12mo ago

Quantitative imaging of lipid transport in mammalian cells www.nature.com/articles/s41...

Durable B-Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis onlinelibrary.wiley.com/doi/10.1002/...

Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis

Objectives Ocrelizumab (OCR), a humanized anti-CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR-MS). We assessed early cellular B-cell profiles in patients...

onlinelibrary.wiley.com

✨We’ve just launched our new guide to #vaccinations during #pregnancy! Understand how immunity changes, which vaccines the NHS recommends, and how they protect both parent and baby during pregnancy and beyond. Download a copy for trusted information: bit.ly/4fuRqVw

Engineering B cells to treat and study human disease www.nature.com/articles/s41... @natbiotech.nature.com

How do lipids shape life? I explore this question in my recent talk for the Build-a-Cell 🦠 seminar series. Thanks to @kateadamala.bsky.social for hosting! Watch it here: youtu.be/JnF7hPCiSbI?...

Build-a-Cell seminar James Saenz: Harnessing minimal cells to understand the living membranes

YouTube video by Build-a-Cell

youtu.be

We’re excited to share a new pre-print from the lab! Led by Carmen Ramirez Moncayo and a fantastic collaboration with several groups from across @mrc-lms.bsky.social & @imperialcollegeldn.bsky.social. Interested in #OvarianCancer, #PARPinhibitors or #DrugDistribution? please read on! bit.ly/45lpekS

Very glad and honored to contribute to this cool study. Check out the latest story on my favorite protein "NINJ1": www.nature.com/articles/s41...

Jie Xu@jie-xu.bsky.social · last yr.

Excited to share our latest story in Nature. We developed a high-throughput cellular stretch system to look for genes regulating membrane rupture under tension, and found an amazing small protein called NINJ1 that weakens the membrane for rupture! H/T to Zozo, my 10-y.o. for her artist's impression😃

This Friday, UK Cell Motility Club symposium in Cambridge, UK: exciting PhD student and Postdoc speaker line up! A few last minute spots available. Follow us on @uk-cmc.bsky.social cytoskeleton.wixsite.com/londoncellmo...

I did my PhD using flies as a model system🩷. FlyBase is amazing, without it my PhD would be much more painful. I can’t imagine it stopping its existence 😥. Sharing for greater reach! Please donate 🙏

Marc Dionne@marcsdionne.bsky.social · last yr.

My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate. www.philanthropy.cam.ac.uk/give-to-camb...

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏 youtu.be/8YhJM6zxYDw?...

Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company

YouTube video by Amanpour and Company

youtu.be

Antigen mobility regulates the dynamics and precision of antigen capture in the B cell immune synapse @pnas.org @katelynspillane.bsky.social www.pnas.org/doi/10.1073/...

Here come our new palette of fluorescent dyes. The BD dyes endeaves to balance glowy brightness, robust photostability, and biocompatibility. Let's boost 4D dynamic super-resolution imaging!!! www.nature.com/articles/s41... @spirochrome.com

A palette of bridged bicycle-strengthened fluorophores - Nature Methods

A suite of bridged rhodamine dyes (BriDyes) offers excellent brightness, solubility, photostability, and tunable cell permeability along with resistance to photoblueing, making them exceptional all-pu...

nature.com

Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis: Immunity www.cell.com/immunity/ful...

Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis

Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...

cell.com

🧠🍔 Just 48 hours on a high-fat diet can weaken gut immunity. Our new study shows saturated fats rapidly impair ILC3s! Proud to see this featured by @wehi-research.bsky.social as I continue to explore these questions @monashuniversity.bsky.social with the IMI Lab!

WEHI (The Walter and Eliza Hall Institute of Medical Research)@wehi-research.bsky.social · last yr.

A landmark WEHI-led study has uncovered how our daily food choices are having an immediate effect on our gut health. Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint #chronicinflammation at the source. Now published in Immunity. www.wehi.edu.au/news/fast-fo...

Looking forward to the Physics within the Cell workshop on 16th June. Join if you want to discuss molecular motors and intracellular transport with me. More info here: iop.eventsair.com/pwtc2025/

New paper out today in @pnas.org from Hannah, Anna, and Maro showing that antigen mobility influences the speed, probability, and precision of B cell antigen extraction in the immune synapse. @annbajur.bsky.social @maroiliopoulou.bsky.social www.pnas.org/doi/epdf/10....

Yes, that is me, for those who did not yet know. This was not planned but I am very happy to go 'home' even though I will miss a lot about Portugal. If you still want to visit, hurry, otherwise see you in Cambridge. If you want to know more contact me directly. www.pdn.cam.ac.uk/news/dr-care...