@curealzheimersfund.bsky.social People who have Alzheimer's disease pathology but no loss of cognition. Why? Discoveries we are making give new insights! See presentations by Isabel Castanho @isabelscst.bsky.social Pourya Naderi @pouryany.bsky.social and Giulia Pegoraro at #AAIC26 here in London.

🏆 Congratulations to our #RNAMedicine2026 poster award winners for their extraordinary research! ⭐️ Mahima Dewani, PhD @harvardmed.bsky.social: Translational Science ⭐️ Marsel Lino, PhD: Basic Science ⭐️ Michelle Luo: Basic Science ⭐️ @pouryany.bsky.social: Collaborative Science

Our research on how the immune checkpoint TIM-3 regulates microglia & Alzheimer's disease highlighted in the @harvard.edu Gazette 👇 🧪 news.harvard.edu/gazette/stor...

Immune-system strategy used to treat cancer may help with Alzheimer’s — Harvard Gazette

Turning off checkpoint molecules freed microglia to attack plaques in brain, improved memory in mice.

news.harvard.edu

The Lipp Lab (@lippilab.bsky.social) has uncovered how microRNAs guide the development of Purkinje cells—rare neurons tied to movement and autism. Published in Neuron, a @cellpress.bsky.social journal, the study maps how precise timing and gene regulation shape these cells’ identity and structure.

How microRNAs act as a “blueprint” for the developing brain

scripps.edu

If you’re attending #adpd2025 drop by to hear about our latest research on #Alzheimers drug target discovery Title: Bringing precision modeling to Alzheimer's Disease. Fri, 04.04.2025 | 18:40 - 19:40 | Hall C

Winston Hide@winhide.bsky.social · last yr.

#adpd2025 insights into the Alzheimer’s continuum. 4/4/25 @19:25 @pouryany.bsky.social will present our new approach to discovering validated targets for AD therapy

#adpd2025 insights into the Alzheimer’s continuum. 4/4/25 @19:25 @pouryany.bsky.social will present our new approach to discovering validated targets for AD therapy

Labeling your axes and then explaining them slowly is perhaps the biggest bang for the buck you can get for making your slides more understandable.

p38 MAPK-MK2 inhibitors (e.g. losmapimod) show new promises in treating Alzheimer's disease. Today @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease

Naderi and Kwak et al. developed IPAA, an integrated cellular/bioinformatics platform. IPAA derisks drug discovery by integrating Alzheimer’s brain gene expression with cellular model functional reado...

cell.com

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵

What are the molecular and cellular hallmarks of resilience and resistance to Alzheimer's Disease? Awesome discoveries with @pouryany.bsky.social @isabelscst.bsky.social We’re growing our team—deliver translation with omics! #cureAlzheimersFund #Postdoc shorturl.at/bGyUqhife hidelab.net

New preprint alert! Check out our manuscript on molecular and cellular hallmarks of resilience and resistance to Alzheimer's Disease (AD) led by @isabelscst.bsky.social and myself from @winhide.bsky.social's Lab. Paper link: doi.org/10.1101/2025... #Alzheimers #Genomics #Aging Details 👇 1/n

Molecular hallmarks of excitatory and inhibitory neuronal resilience and resistance to Alzheimer’s disease

Background A significant proportion of individuals maintain healthy cognitive function despite having extensive Alzheimer’s disease (AD) pathology, known as cognitive resilience. Understanding the mol...

doi.org

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

rdcu.be

Interleukin-23 receptor as a biomarker for aging and potential link to senolytic therapy www.nature.com/articles/s43...

IL-23R is a senescence-linked circulating and tissue biomarker of aging - Nature Aging

Using mouse and human plasma, Carver et al. identify factors that are altered with age and test which are reverted by a panel of genetic and pharmacological senolytic interventions in aged mice. They ...

nature.com

Check out our recent work in Neuron! Our platform helps derisk preclinical to clinical translation by precisely pinning down models that recapitulate pathogenic functions in Alzheimer’s disease brains. Feel free to dm if you are interested in knowing more.

Winston Hide@winhide.bsky.social · 2y ago

🌟 How do you know if your Alzheimer's model truly represents disease 🧠 functions? Bioinformatics+rightCells=rightTargets+right Drug led by Pourya Naderi @pouryany.bsky.social and Sang Su Kwak finally published! Join us! recruiting postdocs hidelab.net 📄 Read it here: tinyurl.com/3vcyy6u5

Today was a great day! Our paper on using an AI platform for cell-free RNA liquid biopsy is finally published in Nature Communications! Huge thanks to our amazing team at @exai.bio for making this happen! The code is open-source and readily available. www.nature.com/articles/s41...

Deep generative AI models analyzing circulating orphan non-coding RNAs enable detection of early-stage lung cancer - Nature Communications

A generative AI model, Orion, learns a robust and generalizable pattern of non-small cell lung cancer from cancer-specific circulating non-coding RNAs. Orion enhances the performance of liquid biopsy ...

nature.com

On the topic of non-negative matrix factorization (NMF, implemented in #RcppML among other #RStats 📦 s) the #NSF paper by Townes & Engelhart citation #7 was great! 💯 (@lahuuki.bsky.social journal club 📹🔜!) www.nature.com/articles/445... published in 1999 shows how NMF gets face elements unlike PCA

Just gonna put up some hashtag to find peeps. #genomics #bioinformatics #singlecell #Alzheimer’s #systemsbiology #compbio #omics