Research from #JoonHyukLee, @quintanalabhms.bsky.social shows astrocytes level-up as non-professional antigen-presenters after interactions w/T cells to boost T cell pathogenicity in CNS autoimmunity.@mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org www.nature.com/articles/s41...

Antigen presentation by CD40+MHC-II+ astrocytes promotes CNS autoimmunity - Nature

Astrocytes promote central nervous system (CNS) immunity through antigen presentation and activation of CD40 in astrocytes by CD40L expressed by CD4+ T cells in a model of experimental autoi...

nature.com

Join us and @genelayinstitute.bsky.social on July 31st for the Annual Symposium! This year's speakers include Marco Colonna, Shimon Sakaguchi, Stefani Spranger, and Gabriel Victora. Register using the QR code in the flyer! #inflammation #immunity #disease #genelayinstitute

💫Back2back papers in @cp-immunity.bsky.social led by #DandanYang: multi-omics studies reveal how the gluococorticoid (GC) pathway restrains Th17 cell pathogenicity. 1️⃣ GC steroid synthesis & sensing maintain the homeostatic state of Th17 cells. #AnaAndersonLab 1/3 🧵 www.cell.com/immunity/ful...

A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell state

Th17 cells can either preserve homeostasis or drive inflammation in tissues; however, the mechanisms that maintain homeostatic phenotypes are not well defined. Yang et al. uncover a cell-intrinsic glu...

cell.com

Online now: A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell state

A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell state

Th17 cells can either preserve homeostasis or drive inflammation in tissues; however, the mechanisms that maintain homeostatic phenotypes are not well defined. Yang et al. uncover a cell-intrinsic glucocorticoid circuit and the underlying gene network by which it maintains homeostasis in Th17 cells. They find that TGF-β1 can reverse the glucocorticoid resistance exhibited by both murine and human inflammatory Th17 cells.

dlvr.it

Online now: Interleukin 23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity

Interleukin 23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity

How IL-23 drives an inflammatory Th17 cell state is poorly understood. Yang et al. identify two coordinated mechanisms specific to IL-23R signaling: the recruitment of CHD1 to stabilize RORγt expression and function and the blockade of glucocorticoid receptor function. Their study explains how IL-23 locks Th17 cells into an inflammatory disease-promoting state and provides a mechanism that explains steroid resistance in Th17 cells.

dlvr.it

IL-23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity @cp-immunity.bsky.social @kuchroolab.bsky.social @harvardmed.bsky.social www.cell.com/immunity/ful...

Inhibitory receptor agonists: Emerging strategies in immune modulation. Review from Kieran R. Adam and Aamir Suhail @vignalilab.bsky.social @kuchroolab.bsky.social: rupress.org/jem/article/... 📘 From #Inflammation Resolution 2026: rupress.org/jem/collecti... #KSInflammation26

An adaptive source of IL-17A/F is indispensable for EAE induction! And B cell-derived IL-17 induces IL-23 signaling required to convert stem-like Th17 cells to encephalitogenic Th17 cells. www.science.org/doi/10.1126/...

An adaptive cellular source of IL-17A and IL-17F is critical for the induction of experimental autoimmune encephalomyelitis

B cells are a critical adaptive immune cell type in the development of TH17 cell–mediated experimental autoimmune encephalomyelitis.

science.org

Review @jem.org @vignalilab.bsky.social @kuchroolab.bsky.social Inhibitory receptor agonists: Emerging strategies in immune modulation rupress.org/jem/article-...

B cells are a critical adaptive immune cell type in the development of TH17 cell–mediated experimental autoimmune encephalomyelitis @sciimmunology.bsky.social www.science.org/doi/10.1126/... @kuchroolab.bsky.social @harvardmed.bsky.social

By reprogramming the tumor microenvironment with an engineered virus, @quintanalabhms.bsky.social boost anti-tumor immunity against glioblastoma. @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social www.massgeneralbrigham.org/en/about/new...

🔔 New episode alert! Dr. Ana Anderson from Harvard Medical School talks about her work on #ImmuneRegulation in cancer. ▶️ https://bit.ly/4pJvw4u

Join us next week for an episode with Dr. Ana Anderson from Harvard Medical School! Her research focuses on understanding the pathways and mechanisms that regulate the #AntiTumor immune response.

Review @natrevneuro.nature.com Immune dysfunction in Alzheimer disease www.nature.com/articles/s41...

Immune dysfunction in Alzheimer disease — a Review by Oleg Butovsky, Neta Rosenzweig, Kilian L. Kleemann, Mehdi Jorfi, Vijay K. Kuchroo, Rudolph E. Tanzi & Howard L. Weiner #neuroscience #neuroskyence www.nature.com/articles/s41...

Immune dysfunction in Alzheimer disease - Nature Reviews Neuroscience

The importance of peripheral immunity in Alzheimer disease has gained much traction in recent years, mainly due to multiple genome-wide association studies identifying risk loci associated with genes ...

nature.com

Beautiful work!

Check out our new study in @ScienceMagazine! Using single-cell transcriptomics, we profile enteric nervous system responses to the microbiota and inflammation, identifying regulators of motor #neuron states and #gut transit time. www.science.org/doi/10.1126/...

The most detailed roadmap to date of how the gut’s nervous system responds to different environmental challenges. Exciting new 🧪study from @thexavierlab.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social | Science www.science.org/doi/10.1126/...

Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation

Enteric neurons are essential regulators of intestinal physiology, yet their responses to varying microbial and immune environments along the intestinal tract and or during challenges remain poorly un...

science.org

Hou, Sun et al from @kuchroolab.bsky.social 2024 in @natureportfolio.nature.com "Neuropeptide signalling orchestrates T cell differentiation" www.nature.com/articles/s41...

Neuropeptide signalling orchestrates T cell differentiation - Nature

RAMP3, a component of the receptor for the neuropeptide CGRP, has a cell-intrinsic role in T helper type 1 cell fate determination.

nature.com

We're less than a week away from #ReThinkNeuroimmunology — a groundbreaking conference hosted by the @genelayinstitute.bsky.social! We’re thrilled to welcome experts, ignite new ideas, & push the field forward. Huge thanks to our incredible sponsors for making #RTN2025 possible! 🧵👇

#KuchrooLabReunion at #CSNeuroimmune25 in NYC with VKK & Manu Rangachari

This conference is going to be great! Looking forward to it.

RTN Conference@rtnconference.bsky.social · 12mo ago

#ReThinkNeuroimmunology! 3 days 27 speakers 7 selected talks 2 panel discussions >400 registered Submit your abstract by August 28th for #RTN2025. 🔗 genelayinstitute.org/rtn/ 🧪 @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua

This conference is going to be great! Looking forward to it.

Blockade of STUB1 in T cells boosts anti-tumor immunity. Study from the #SharpeLab led by @martinlafleur.bsky.social & #LaurenMilling @natimmunol.nature.com. @genelayinstitute.bsky.social @harvardmed.bsky.social @broadinstitute.org hms.harvard.edu/news/researc... www.nature.com/articles/s41...

REV-ERBα & REV-ERBβ, which control clock gene expression, also maintain ILC3 in a state that facilitates the maintenance of a balanced and healthy intestine @natimmunol.nature.com #ColonnaLab www.nature.com/articles/s41... preview @theonlylabever.bsky.social www.nature.com/articles/s41...

🚨 New study from the lab of our Vice Director, Arlene Sharpe, led by @kepauken.bsky.social & #SamuelMarkson in @jem.org. PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic & a cell-extrinsic fashion🧪

Journal of Experimental Medicine@jem.org · last yr.

@kepauken.bsky.social, Markson, Sharpe et al. @harvardmed.bsky.social show that when PD-1–expressing and PD-1 knockout CD8+ T cells are within the same tumor microenvironment, both cell types exhibit similarly enhanced functions. rupress.org/jem/article/...

Cellular & spatial profiling of fibrosis in Crohn's disease provides new insights into the mechanisms involved. From the lab of our Vice Director @thexavierlab.bsky.social in collaboration with #SmillieLab. Study led by #LingjiaKong @broadinstitute.org

Nature Genetics@natgenet.nature.com · last yr.

📢ONLINE @natgenet.nature.com 📰Single-cell and spatial transcriptomics of stricturing #Crohn’s disease highlights a fibrosis-associated network. By Lingjia Kong, ‪@thexavierlab.bsky.social‬ and colleagues. ⬇️ www.nature.com/articles/s41...