MHC restriction is structurally encoded by the T cell receptor germline https://www.biorxiv.org/content/10.64898/2026.09.24.754241v1

You can now view our abstract using this link and the summary images below: www.biorxiv.org/content/10.6... @obigriffith.bsky.social @malachigriffith.bsky.social @thehumanborch.bsky.social #Rheumsky #axSpA (1/4)

Hi, we would like to introduce PAIR-Scan, an HLA-agnostic library-on-library screening technology that can identify reactive TCR–antigen pairs with optimal killing activity among up to ~100,000 possible candidate pairs in a single-step. 🧵(1/7) www.biorxiv.org/content/10.6...

Succinct and clear-headed perspective on the unknowns of MS and what they might mean for its pathogenesis. I enjoyed reading it. www.nature.com/articles/s41...

Common viral infections seed regionally distinct resident memory T cells in the human CNS https://www.biorxiv.org/content/10.64898/2026.09.21.753190v1

Spatial organization of AQP4 water channel expression in the human brain www.science.org/doi/10.1126/...

Spatial organization of AQP4 water channel expression in the human brain

Aquaporin-4 (AQP4) water channels support the glymphatic system, a brain-wide pathway that clears cerebral waste products. Here, we use AQP4 gene expression to reconstruct a whole-brain glymphatic-rel...

science.org

Pleased to be joining Joanne Guo as the new Assistant Fellowship Program Directory for our MS and Neuroimmunology Fellowship at UCSF We are having a virtual Open House on October 2 at 10-11 am PT for those interesting in learning more! Registration here: ucsf.zoom.us/webinar/regi...

VDJdb in 2026: boosting T-cell receptor recognition evidence using paratope embeddings and AI-based structure prediction academic.oup.com/nar/advance-...

VDJdb in 2026: boosting T-cell receptor recognition evidence using paratope embeddings and AI-based structure prediction

Abstract. We present a significant update to VDJdb, introducing substantial enhancements to both the data content and the technical infrastructure. The int

academic.oup.com

Immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donors www.frontiersin.org/journals/imm...

Frontiers | Immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donors

BackgroundMemory T cells are records of clonal expansion from prior immune exposures such as infections, vaccines and chronic diseases. Some of the receptors...

frontiersin.org

Join us! 👇

Stacie Dodgson, PhD@staciedodgson.bsky.social · last wk.

📣📣 Looking for new faculty @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social Genomic Immunology: aprecruit.ucsf.edu/JPF05958 We are broadly interested in immunotherapy - discovery, design, engineering, and translation, across the full spectrum of modalities and disease indications.

Train in autoimmune neurology: adult + pediatric clinical care, research, education and real-world experience. Applications are open now; first interviews begin late fall 2026. neuro.fellowship@hsc.utah.edu https://medicine.utah.edu/neurology/fellowship-programs/autoimmune

Very honoured to be hosting Prof @kischober.bsky.social at Unravelling T cell recogition webinar series @imm.ox.ac.uk Kilian will present his latest work exploring how EBV-reactive T cells may contribute to CNS autoimmunity in multiple sclerosis. Join me. #TCells #Immunology #MultipleSclerosis #EBV

Anti-CD40L prevents meningeal B cell aggregates and mitigates progressive autoimmune encephalomyelitis academic.oup.com/brain/advanc...

This is a great overview and critique by Gavin Giovannoni of the recent EBV MS relapse paper

Prof G@gavingiovannoni.bsky.social · 2w ago

#MS_Selfie Research: Is EBV reactivation the trigger driving MS relapses? Their proposed model is that abortive EBV reactivation occurs within a genetically permissive peripheral immune compartment before clinical relapse. gavingiovannoni.substack.com/p/is-ebv-rea...

Applications are open for Utah's Autoimmune Neurology Fellowship—adult + pediatric training, clinical care, research and diagnostics. First interviews begin late fall 2026. neuro.fellowship@hsc.utah.edu https://medicine.utah.edu/neurology/fellowship-programs/autoimmune

EBNA1381-452 and Cross-Reactive Antibody Responses Reveal Immune Signatures in Multiple Sclerosis www.neurology.org/doi/10.1212/...

EBNA1381-452 and Cross-Reactive Antibody Responses Reveal Immune Signatures in Multiple Sclerosis | Neurology Neuroimmunology & Neuroinflammation

Background and ObjectivesInfection with the Epstein-Barr virus is a prerequisite for the development of multiple sclerosis (MS). Recent evidence has identified an antibody response against a peptide r...

neurology.org

Universal seropositivity, markers of recurrent reactivation, and a convergent T-cell response implicate cytomegalovirus in Susac syndrome www.researchsquare.com/article/rs-1...

Check out this webinar hosted by @hkoohy.bsky.social (@ox.ac.uk). I am looking forward to speaking about our new findings on the role of EBV-specific T cells in multiple sclerosis (preprint coming soon). More info in the flyer - the link for registration is here, too: us06web.zoom.us/meeting/regi...

Hello! I've started my lab and we're looking to hire at multiple positions: 1-Postdoc 2-Scientist (primarily Computational biologists) 2-Lab manager 3-Tech If you're interested, please reach out to my institutional email. Looking forward to discussing further.

EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse www.nature.com/articles/s41...

EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse - Nature Medicine

Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to the development of MS r...

nature.com

Want to join Arc? We're hiring experts in disease bio, computational bio, functional genomics, and NGS for our Tech Centers, plus postdocs and research associates in our Core Labs. All roles are based in Palo Alto, and are on-site or hybrid. Learn more or apply here: lnkd.in/gyfgqR3n

Jobs | Arc Institute

Arc Institute is an independent nonprofit research organization headquartered in Palo Alto, California.

arcinstitute.org

PAIR-Scan: Single-step identification of highly potent TCR-neoantigen pairs through library-on-library screening https://www.biorxiv.org/content/10.64898/2026.09.07.749948v1

Immune Profiling after treatment with an Anti-CD19 Chimeric Antigen Receptor T Cell Therapy in Treatment-Refractory Progressive Multiple Sclerosis Exciting new work from Sasha Gupta, Bruce Cree and colleagues! www.medrxiv.org/content/10.6...

Immune Profiling after treatment with an Anti-CD19 Chimeric Antigen Receptor T Cell Therapy in Treatment-Refractory Progressive Multiple Sclerosis

Treatment targeting progressive multiple sclerosis (MS) have limited efficacy, as central nervous system (CNS) resident B cells are resistant to peripheral B cell depletion by antiCD20 monoclonal anti...

medrxiv.org

Opinion @cp-trendsimmuno.bsky.social Understanding HLA risk in immune-mediated inflammatory diseases requires antigen discovery www.cell.com/trends/immun...

Multimodal discovery of a pathogenic B cell-dependent T cell state in multiple sclerosis academic.oup.com/brain/advanc...

Multimodal discovery of a pathogenic B cell-dependent T cell state in multiple sclerosis

Farooq et al. show that B cell depletion in multiple sclerosis indirectly disrupts a proinflammatory-cytotoxic T cell state. Convergent evidence across dis

academic.oup.com

💙 #MOGAD update: The FDA granted Priority Review to Genentech’s application for Enspryng® (satralizumab). In Phase III, it reduced relapse risk by 68%. If approved, it could be the first FDA-approved MOGAD treatment. Decision expected Jan. 10, 2027. www.gene.com/media/press-...

Marked benefit of Covid updated or booster vaccination in people with autoimmune conditions Real world evidence for over 60,000 individuals with major (40-70%) reduction of hospitalization acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Updated <fc>COVID</fc>‐19 Vaccines and Health Outcomes in Patients With Autoimmune Rheumatic Conditions

Objective We aimed to assess the association between COVID-19 vaccination status and COVID-19-related hospital admissions, need for mechanical ventilation or extracorporeal membrane oxygenation (ECM...

acrjournals.onlinelibrary.wiley.com

For people with multiple sclerosis with asymptomatic active lesions on MRI, dose high dose steroid treatment reduce conversion to a "black hole" on MRI, indicating irreversible axonal damage? According to this randomized trial, no! It makes no difference pubmed.ncbi.nlm.nih.gov/42711838/

Evaluation of MRI asymptomatic gadolinium-enhancing lesions conversion to persistent black hole with high‑dose methylprednisolone pulse therapy in relapsing remitting multiple sclerosis patients: a randomized trial - PubMed

Intravenous methylprednisolone pulse therapy administered for asymptomatic gadolinium-enhancing lesions was not associated with a statistically significant reduction in the formation of chronic T1 black holes over a 6-month follow-up period.

pubmed.ncbi.nlm.nih.gov

NIH to continue discussing only the top 1/3 of applications. This is a disservice to the research community. Fewer applications will get the higher quality of review from discussion. Applicants will get less nuanced feedback from review. grants.nih.gov/grants/guide...

Peptide-coupled red blood cells emerge as a promising autologous cell therapy for achieving antigen-specific immune tolerance in multiple sclerosis in a clinical trial of 10 patients. In PNAS: https://ow.ly/IkYP50ZKHUf