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Giorgio Seano

@giorgioseano.bsky.social

Head of the Tumor Microenvironment Laboratory at Institut Curie. #CancerResearch, #Neuro-oncology, #BrainTumor, #GBM, #Glioblastoma, #ResistanceMechanism, #TumorMicroenrironment, #TME, #Mechanobiology, #CellPlasticity https://institut-curie.org/team/seano

107 Posts1571 Follower937 Folgt
Giorgio Seano@giorgioseano.bsky.social · 2mo ago

I am thrilled to co-organize the upcoming Paris Neuro-Oncology Conference (January 27-29, 2027), alongside an exceptional group of colleagues and brain tumor experts. Abstracts by Sept 18, 2026 Join us in Paris to discuss the latest frontiers in neuro-oncology. my.weezevent.com/paris-neuro-...

Paris Neuro-Oncology Conference

The conference program will aim to highlight the constant evolution throughout life of the developmental, immune and neuronal contexts of brain tumors The thematic sessions will seek to establish lin...

my.weezevent.com

Paris Neuro-Oncology Conference@pnoc2027.bsky.social · 2mo ago

📢 Registration is open for the Paris Neuro-Oncology Conference 🇫🇷🧠 🗓 Jan 27–29, 2027 | Paris 🎙 CALL FOR ABSTRACTS Early-career researchers are invited to submit abstracts for oral & poster sessions before Sept 18, 2026. 📩 contactpnoc@gmail.com 🔗 my.weezevent.com/paris-neuro-...

Giorgio Seano@giorgioseano.bsky.social · 6mo ago

New in Science Advances: Steroid-dependent metabolic rewiring in #Glioblastoma reveals novel therapeutic and imaging approaches. 🧠🔬 Honored to be involved in such a stimulating study! Read here: www.science.org/doi/full/10....

Steroid-dependent metabolic rewiring reveals novel therapeutic and imaging approaches for glioblastoma

Dexamethasone reprograms glioblastoma nicotinamide metabolism, sensitizing tumors to methionine restriction and enabling PET.

science.org

SUNRiSE network@sunrise-network.bsky.social · last yr.

Amazing job! Well done guys! Funny how conventional therapies enrich for hybrid GBM cells🤩

Giorgio Seano@giorgioseano.bsky.social · last yr.

🧠 Why does glioblastoma always outsmart treatment? In our #Neuro-Oncology paper, we identified proneural-mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. doi.org/10.1093/neuo... Short walkthrough below. Let’s dive in! 🧵 (1/9) #GBM, #BrainTumor

Background: Despite extensive research efforts, glioblastoma (GBM) remains a deadly disease with poor prognosis. Although previous studies have identified various cell states within GBM tumors, the molecular mechanism underlying adaptive GBM cell plasticity induced by conventional therapy remains unclear. Methods: We used fluorescent reporters for proneural (PN) and mesenchymal (MES) subtypes to monitor GBM cell plasticity in real-time across multiple patient-derived cell lines. This approach revealed cells that concurrently expressed both proneural and mesenchymal markers. To investigate this unique hybrid population, we implemented a comprehensive methodological approach encompassing bulk and single-cell RNA sequencing, single-cell ChIP sequencing, nuclear proteomics, high-resolution imaging, orthotopic mouse models, clinical dataset analysis, and pharmacological and genetic techniques. This multifaceted strategy allowed us to gain functional and molecular insights into this distinct cellular population. Results: We showed that these hybrid cells are increased by conventional therapies, and are resistant to these therapies. At the molecular level, hybrid cells display significant alterations in chromatin structure and nuclear protein composition, elevated transcriptional activity, Myc activation, and improved transport between the nucleus and cytoplasm. Genetic and pharmaceutical inhibition of the nuclear import/export shuttling machinery, increased in hybrid cells, effectively suppressed adaptive GBM cell plasticity and hybrid identity, thereby enhancing the sensitivity of GBM cells to therapies. Conclusion: Our results indicate that GBM hybrid cells play a crucial role in chemoradiation resistance. The nuclear transport machinery presents a potential therapeutic target for hybrid cells, offering a way to counteract the typical resistance to treatment observed in GBM.
OncoDaily@oncodaily.bsky.social · last yr.

Why Does Glioblastoma Always Outsmart Treatment? - Giorgio Seano @giorgioseano.bsky.social @institutcurie.bsky.social @valentino-ribecco.bsky.social @ggargiul.bsky.social oncodaily.com/science/glio... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Glioblastoma #NeuroOnc

Giorgio Seano: Why Does Glioblastoma Always Outsmart Treatment? - OncoDaily

Giorgio Seano: Why Does Glioblastoma Always Outsmart Treatment? / Adrien Thomas, Alberto Ballestín, cancer, Cathy Pichol-Thievend, Celine Vallot, Curie

oncodaily.com

Anna Clemens, PhD@annaclemens.com · last yr.

🎧 I made this list in 2021, but these podcasts are still in my rotation! If you're a researcher looking for relevant and useful information for academics, check out these top podcast suggestions and learn something new this week. -> https://rpst.page.link/rxCs #AcademicWriting #PhDSky #PhDchat

Academic Podcasts for Researchers & Scientists

Looking for the best academic podcasts? I have recommendations for academic writing podcasts, podcasts for PhD students and other podcasts on academia – from leadership and academic life to teaching.

rpst.page.link

Giorgio Seano@giorgioseano.bsky.social · 2y ago

Looking forward to meeting a lot of good international and French friends at the Brain Tumor Microenvironment Symposium organized by the Institut du Cerveau... Super cool lineup!! #GBM #TME curamus-cancer.fr/brain-tumor-...

SAVE THE DATE: Brain Tumor Microenvironment Symposium, 30th & 31st January 2025, Paris - Siric Cancer - Curamus - Site de Recherche Intégrée sur le Cancer

Dans le cadre de son programme de recherche intégrée « Cerveau, cancer et immunité – dialogue cellulaire dans les tumeurs cérébrales », […]

curamus-cancer.fr

Brendan Harley@profharley.bsky.social · 2y ago

Wanted to stat today with some new #harleylab science. ChiaWen Chang is leading efforts to understand immune cell patterning in the brain in glioblastoma. He started w/ the inverse question: how do GBM cells influence microglia (brain-resident immune cells)? www.sciencedirect.com/science/arti...

Glioblastoma drives protease-independent extracellular matrix invasion of microglia

Glioblastoma (GBM) is the most common and lethal form of primary brain cancer. Microglia infiltration into the tumor microenvironment is associated wi…

sciencedirect.com

@valeramponi.bsky.social · 2y ago

I am thrilled to finally share our work on persister cancer cells: we identify distinctive features and actionable #vulnerabilities ⚡️of persister cancer cells (#DTP), and provide mechanistic insight into their low #inflammatory activity: aacrjournals.org/cancerres/ar...

H4K20me3-Mediated Repression of Inflammatory Genes Is a Characteristic and Targetable Vulnerability of Persister Cancer Cells

Cell persistence and senescence are distinct states of proliferative arrest induced by cancer therapy, with persister cells being characterized by the silencing of inflammatory genes through the heter...

aacrjournals.org

Eric Topol@erictopol.bsky.social · 2y ago

A new large language of life model (LLLM) for the transcriptome that predicts gene expression within and across human cell types www.nature.com/articles/s41... @nature.com For more on the remarkable surge of LLLMs see erictopol.substack.com/p/learning-t...

A foundation model of transcription across human cell types - Nature

A foundation model learns transcriptional regulatory syntax from chromatin accessibility and sequence data across a range of cell types to predict gene expression and transcription factor interactions...

nature.com

Elaine Fuchs Lab@thefuchslab.bsky.social · 2y ago

Cancers may arise in tissues with a low mutational burden. It’s up to the microenvironment! We discussed this in @natrevcancer.bsky.social www.nature.com/articles/s41...

Beyond genetics: driving cancer with the tumour microenvironment behind the wheel - Nature Reviews Cancer

In their Review article, Fuchs and colleagues discuss how a single or a few mutations in adult cells can lead to invasive cancers without a high mutational burden, demonstrating that non-genetic ...

nature.com

Baptiste Lacoste@blacoste.bsky.social · 2y ago

New study on the pathogenic role of hypoxia in #BloodBrainBarrier disruption, with implications for vascular dementia #cerebrovascular academic.oup.com/braincomms/a...

Blood–brain barrier disruption and microglial activation during hypoxia and post-hypoxic recovery in aged mice

Sapkota et al. show that hypoxia triggers vascular breakdown and microglial activation in the brain. While return to normoxia results in vascular repair, m

academic.oup.com

Gaetano Gargiulo@ggargiul.bsky.social · 2y ago

End-of-the-year preprint & first 🧵 where the sky is blue! Ever wondered how a cancer driven by a single mutant oncogene becomes molecularly & cellularly heterogeneous? Why metastases share drivers w/primary tumors but are more aggressive?