Sunny Crete for a great meeting about #cancer #ecology and #evolution

Rob Noble@robjohnnoble.bsky.social · 8mo ago

The deadline to submit your abstract(s) for the International Society for Evolution, Ecology and Cancer conference via www.evocancer.com has been extended to Monday 19th January at 09:00 GMT. The conference will take place on 21st-24th May in Hersonissos, Crete.

Still a few days to apply for a PhD studentship in my lab as part of the MSCA doctoral training network EVOMG! Come help us develop informative models of blood-based biopsies in cancer, and learn about the various evolutionary aspects that can aid medicine. More info and application: www.evomg-dn.eu

Check out our article on the evolution of immune evasion in colorectal cancer. ⬇️ For a summary, see our Research Briefing now available online: rdcu.be/ePWC4

Timing and mechanisms of immune evasion in colorectal cancers

Nature Genetics - Evading elimination by the immune system is a hallmark of cancer, but the exact timing and pathways of immune evasion are still to be explored. Colorectal cancers were found to...

rdcu.be

Trevor Graham@trevorgraham.bsky.social · 11mo ago

New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...

Now that our Nature Genetics paper is out, here’s a “Behind the Paper” post on how colorectal cancers outsmart the immune system from the beginning. 👉 communities.springernature.com/posts/when-c... @eszterlakatos.bsky.social @trevorgraham.bsky.social #CancerResearch #Immunology #TME #Epigenetics

When Cancers Outsmart the Immune System from the Very Beginning

Cancer research is often seen as an arms race between the immune system and cancer cells, unfolding gradually as tumors grow. But our new study on colorectal cancer suggests otherwise: the battle may ...

communities.springernature.com

New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...

Epigenetically driven and early immune evasion in colorectal cancer evolution - Nature Genetics

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

nature.com

📢 EvoMG-DN PhD applications are now open! Join our EU-funded MSCA network and explore evolution, ageing, and disease. 👉 www.evomg-dn.eu 📅 Apply by 30 November 2025 #PhD #DoctoralTraining #MSCA #HorizonEurope #Genomics #EvolutionaryBiology #BiomedicalResearch#EarlyCareerResearchers

Check out how we tackled one of the fundamental challenges in immunology, out today @cp-cellsystems.bsky.social: www.cell.com/cell-systems.... Our major innovations are BATCAVE and BATMAN, two new players to get us closer to solving TCR-pMHC predictions!

T cell receptor cross-reactivity prediction improved by a comprehensive mutational scan database

Banerjee et al. present a comprehensive T cell receptor cross-reactivity database and a hierarchical Bayesian framework to predict T cell receptor targets. Together, they reveal structural and biochem...

cell.com

Sleep when the baby sleeps, eat when the baby eats, edit your manuscript when the baby edits their manuscript

🏆 Honoured to receive the 2025 Inaugural BACR Early Career Award! Grateful to @thebacr.bsky.social and all who’ve supported me — esp. @trevorgraham.bsky.social, @eszterlakatos.bsky.social & @cancerresearchuk.org 💙 Reflections→ www.bacr.org.uk/news/2025-in... #CancerResearch #EarlyCareer #ScienceWins

The British Association for Cancer Research@thebacr.bsky.social · last yr.

2025 Inaugural BACR Early Career Award Recipient

Very cool story and especially useful mathematical models for everyone to use! Check it out!!!

Trevor Graham@trevorgraham.bsky.social · last yr.

Using barcodes 📊 to track cancer 💊 resistance evolution: is it clonal selection or plasticity? @fwhiting.bsky.social‬ knows! His new "Evolutionary Informed Resistance Assays" (EIRAs) framework infers resistance evolution dynamics from barcode diversity data. www.nature.com/articles/s41... @icr.ac.uk

As much as it's a meaningless milestone, the mathematician in me is happy to see exactly 2^10 citations on the one random day I decide to finally visit my own Google Scholar :)

🚨With some delay, we're excited to announce that our proposal for a MSCA Doctoral Network on Evolutionary Medical Genomics (EvoMG-DN) got funded! 🎉 🧬 14 labs and 2 companies across 7 European countries will be coordinated by the EvoMG Joint Program at @crg.eu & @upf.edu. europa.eu/!NNq63m

Happy to share details of this meeting and the exciting line-up of speakers. Hope to see you there. Please re-post www.crick.ac.uk/whats-on/5th...

Tour de force from @melissabarroux.bsky.social on evolutionary and microenvironmental dynamics of oesophageal adenocarcinoma through neoadjuvant therapy Published @natcancer.nature.com Melissa is an outstanding new clinician scientist.. one to watch. www.nature.com/articles/s43... @icr.ac.uk

Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma - Nature Cancer

Graham and colleagues analyzed locally advanced esophageal adenocarcinoma clinical trial patient samples and identified major changes in gene expression profiles and immune microenvironment compositio...

nature.com

📣Open PhD position in Machine Learning at Uppsala University. Focus: Bayesian mathematical models and methods for biomedicine.

Can we use the power of evolution to improve ovarian cancer treatment? Our latest paper says yes! Online now at Cancer Research. Thanks to @trevorgraham.bsky.social coauthors and @cancerresearchuk.org for funding.

📰 Can we use the power of evolution to improve ovarian cancer survival? A surprising approach called adaptive therapy holds promise, according to findings by @mlockley.bsky.social & team at @qmul.ac.uk & @icr.ac.uk. Read more ➡️ www.bci.qmul.ac.uk/general-news... #AACR25 #medsky #oncosky🧪

Smarter chemotherapy approach could delay drug resistance in ovarian cancer - Barts Cancer Institute - Queen Mary University of London

Adaptive chemotherapy can prolong survival in lab models of ovarian cancer, according to new results. The findings could pave the way for a more effective and gentler approach to treating ovarian canc...

bci.qmul.ac.uk

If you're a PhD student interested in using maths to understand cancer, this HCEMM summer school in Szeged, Hungary, is an excellent opportunity. Registration is free and local costs are covered, so apply before 15th April.

Our #Cancer #Evolution summer school runs again 30 June-3 July at the beautiful Genome Campus in Hinxton, UK sponsored by @wellcometrust.bsky.social Ideal for starters in the field; this year's focus is on using genomic data for cancer evo research. Brilliant & inspiring faculty! bit.ly/40nLdDD

Wellcome Connecting Science Learning and Training@eventswcs.bsky.social · 2y ago

Working in #CancerBiology? Join us at our expert-led #EBECancer25 course, to discover how insights on the #evolutionary and ecological aspects of #cancer are shaping the future for improved clinical treatments.💊 📅 30 June-3 July 2025 ⏰Apply by 1 April! 📎bit.ly/40nLdDD @sysbiocurie.bsky.social

We have an opening in our #DataScience core @icr.ac.uk. The post will work on a breadth of topics across #cancer biology, but expertise in spatial data, single cell and data integration are priorities. Details here: jobs.icr.ac.uk/vacancies/11... @jobrxiv.bsky.social

Data Scientist in Sutton | The Institute of Cancer Research

View details and apply for this Data Scientist vacancy in Sutton. Salary Range: Commencement on the salary range is subject to comparable skills and experience. Future progression is based ...

jobs.icr.ac.uk

Come work at the European Molecular Biology Laboratory in the beautiful science & university city Heidelberg as a Research Software Engineer on R/Bioconductor tools for biological data science and AI ! embl.wd103.myworkdayjobs.com/EMBL/job/Hei...

Delighted our work using aneuploidy as a biomarker of colorectal cancer risk in inflammatory bowel disease is out: gut.bmj.com/content/earl... The initial reaction from patients&families has been overwhelming Led by Ibrahim AlBakir @yosoykit.bsky.social @cancerresearchuk.org @icrlondon.bsky.social

Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis

Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and dif...

gut.bmj.com

Applications for this "Black Leaders in Cancer" #PhD studentship with our lab @icrlondon.bsky.social close on Thursday... if you know of someone who might be interested please do pass the link on.

Trevor Graham@trevorgraham.bsky.social · 2y ago

We have an open #PhD #studentship as part of our "Black Leaders in Cancer" programme at @crukconvergence.bsky.social & @icrlondon.bsky.social. About computational modelling of T-cell evolution in cancer. www.findaphd.com/phds/project... I'm looking forward to meeting prospective students #CRUKfunded

Excited to share our perspective on genetic immune escape alterations and their impact on tumor evolution, metastasis, immunotherapy, and interactions with tumor-extrinsic factors. It was a pleasure collaborating with Diego on this -hope you enjoy the read!☺️ www.sciencedirect.com/science/arti...

Genetic immune escape in cancer: timing and implications for treatment

Genetic immune escape (GIE) alterations pose a significant challenge in cancer by enabling tumors to evade immune detection. These alterations, which …

sciencedirect.com

Our paper on chromosomal abnormalities in normal breast tissue from BRCA carriers came out last week. www.nature.com/articles/s41...

Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations - Nature Genetics

Single-cell DNA sequencing identifies recurrent copy number changes in healthy breast tissue from women with wild-type or germline BRCA1 or BRCA2 mutations.

nature.com

Calling all systems and computational biologists in search of a faculty position: We have Assistant and Associate Professor positions! 🚀 Pittsburgh is beautiful, and we are doing amazing science here. cfopitt.taleo.net/careersectio... cfopitt.taleo.net/careersectio... Please apply by Dec 2!

Reminder for newcomers that bioRxiv has Bluesky accounts in every subject category - great way to keep up (please re-skeet) connect.biorxiv.org/news/2023/09...

We have an open #PhD #studentship as part of our "Black Leaders in Cancer" programme at @crukconvergence.bsky.social & @icrlondon.bsky.social. About computational modelling of T-cell evolution in cancer. www.findaphd.com/phds/project... I'm looking forward to meeting prospective students #CRUKfunded

I suppose now is a good time to introduce #BiologyInNumbers, a #SciComm podcast I have the pleasure of directing, producing & hosting. Thought up by then-President Heiko Enderling, it's a means to learn about @smbmathbiology.bsky.social and research from its members and the wider #mathBio community.

Couldn't wish for a better BlueSky debut post: Our spatial atlas of the developing thymus is now published in Nature! 🥳 www.nature.com/articles/s41... Also check out the other papers in the new Human Cell Atlas collection: www.nature.com/collections/... #singlecell #spatial #multiomics

A spatial human thymus cell atlas mapped to a continuous tissue axis - Nature

A quantitative morphological framework for the human thymus reveals the establishment of the lobular cytokine network, canonical thymocyte trajectories and thymic epithelial cell distributions in...

nature.com