🚀 We're hiring! Join the founding Digital Twin Team at the SCALE Cluster of Excellence @goetheuni.bsky.social Apply by: 31 August 2026 For more information: scale-frankfurt.org/wp-content/u... Full position description: scale-frankfurt.org/wp-content/u... Descriptions below 🧵:

Seminar Alert *Lineage Tracing and Disease modeling in human embryos* Rio Sugimara, Hong Kong University When: 26. 06. 2026, 15:00 Where: H22-2, Medical faculty, Goethe University Frankfurt @riosugimura.bsky.social @cpi-exstra.bsky.social @goetheuni.bsky.social @scale-cluster-ffm.bsky.social

1/3: We are excited to share a new study by Maarten Tuijtel from @becklab.bsky.social, published in eLife. 🔬 🎉 The work addresses a key question in cryo-electron tomography: how to best distribute the limited electron dose across a tilt series while balancing angular sampling and image quality. 💥

How can a splicing factor bind to thousands of exons but regulate only a few of them? In our new preprint, we show that SRSF6 resolves this paradox through two distinct binding modes. @lab-nmr.bsky.social & @julianvonehr.bsky.social. Check it out: www.researchsquare.com/article/rs-9...

Congratulations, Erin Schuman! The director at the Max Planck Institute for Brain Research receives the #KavliPrize 2026 in the field of #neuroscience 🎉 @kavlifoundation.org @mpibrain.bsky.social

Seminar Alert: *Prof. Elena Conti* 'RNA exosome complex: Molecular Mechanisms of RNA degradation in health and disease' When: 18.06.2026, 14:00 Where: Haus 22-1 (lecture hall H22-1), Neiderad Campus (Uni KliniK), Goethe University RT🙏 @scale-cluster-ffm.bsky.social @goetheuni.bsky.social

Our lab is expanding! We are looking for a PhD candidate interested in RNA localization & targeting as part of the newly funded TRR440 smART: specific mRNA targeting. An exciting opportunity to work on RNA biology & innovative approaches in a collaborative environment. For details shorturl.at/RjyhE

🚨 New paper alert from SCALE faculty! Antibiotic resistance is one of the biggest challenges in modern medicine, and efflux pumps help Gram-negative bacteria evade many antibiotics. Paper: www.nature.com/articles/s44...

Der neue UniReport 1/2026 ist da 📰 Unter anderem mit dem Auftakt des Exzellenzclusters @scale-cluster-ffm.bsky.social, Poetikvorlesungen, Nachrufen auf Jürgen Habermas und einer Story mit vier Wegen aus dem Ukraine-Krieg. 👉 Jetzt lesen: www.unireport.info/aktuelle-aus....

🔬we have been playing with 'an old tool from (DNA) chemistry' 🧪 and used that for DNA-based confocal/super-res microscopy ... these are the last recordings for the revision and were recorded last night ... 🙏 thanks to R1 for this suggestion:

Goethe University now has a state-of-the-art scanning electron microscope with nanomanipulator 🤩. It enables precise nanobiopsies of biological samples and is a key technology for the Cluster of Excellence @scale-cluster-ffm.bsky.social. 🔗 Read more: aktuelles.uni-frankfurt.de/english/a-vi...

🌟 PhD positions at IMPRS-CBP! Applications open from Jan 23 – Mar 11. Fully funded PhDs in cellular biophysics at @mpibp.bsky.social , @goetheuni.bsky.social l and @unimainz.bsky.social . 👉 imprs-cbp.mpg.de #phd #biophysics #imprs_cbp

🧪 Forschende der Goethe-Uni haben das Enzym Fettsäuresynthase neu programmiert, um nachhaltige Fettsäuren ohne #Palmöl zu produzieren. Durch gezielte Veränderungen können nun kürzere Kettenlängen hergestellt werden. 🔗 Mehr: aktuelles.uni-frankfurt.de/forschung/de... @scale-cluster-ffm.bsky.social

🧪 Researchers at Goethe University have reprogrammed the enzyme fatty acid synthase to produce sustainable fatty acids without #palm#oil. Through targeted modifications, shorter chain lengths can now be produced. 🔗 More: aktuelles.uni-frankfurt.de/english/from... @scale-cluster-ffm.bsky.social

🚀 Giersch International Conference & SCALE Kick-Off on Digital Twins is coming up! 🗓️ March 2–5, 2026 | 📍 Frankfurt Main Experts in digital twins & structural cell biology come together to discuss, challenges & future directions in biology.

⏰Call for Applications - Join Our Team and Help Shape Our Cluster @goetheuni.bsky.social and the Cluster of Excellence SCALE - Subcellular Architecture of Life are seeking 3 highly motivated scientists to join a vibrant and innovative research community on Campus Riedberg. Share with your network!

Vault particles, a 40-year cell biology mystery, associate with membranes at the nuclear envelope and ER—revealing a new functional axis for these conserved complexes @kgeissler.bsky.social @yuningwang.bsky.social @jpkreysing.bsky.social @Becklab.bsky.social: www.biorxiv.org/content/10.6...

The last chapter from my postdoc days is finally online! We solve structures of the ER membrane O-mannosyltransferase Pmt4 and uncover a functionally important cytosolic binding site for the Dol-P-Man substrate lipid - allosteric regulation or a long sought after Dol-P-Man flippase?? 🔄 rdcu.be/eUJfb

Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6... Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet

How liquid-like is the nuclear pore barrier?🍝𖣐 Our new preprint shows that FG-NUPs exhibit nanosecond-scale, liquid-like mobility in living cells. 💧⚡O-GlcNAcylation and an importin-β gradient keep the FG network liquid-like, reconciling nuclear pore complex models.

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 8mo ago

O-GlcNAcylation and an importin-β radial gradient keep the FG barrier liquid in live-cell nuclear pores https://www.biorxiv.org/content/10.64898/2025.12.09.693204v1

Before you decorate the tree, come decorate your RNA next Thursday, 4 pm, 18.12.2025 Our last RNA event before the holidays. Also:Glühwein&snacks Registration: rmu-rna-salon.idloom.events/2-rmu-rna-sa... Please share @mixmue.bsky.social @cpi-exstra.bsky.social @scale-cluster-ffm.bsky.social

It’s out 🥳🥳. Amazing new insights into Paraspeckles by SMART 3D STED imaging. Paraspeckles can be polar and fuse and have an interesting loop that contacts the nucleoplasm. Kudos to @heilemannlab.bsky.social, Sjoerd Stallinga and Bernd Rieger.

Heilemann Lab@heilemannlab.bsky.social · 8mo ago

We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social 🙏 (1/3) www.nature.com/articles/s41...

One of our founding directors Anthony Hyman @hymanlab.bsky.social will become @embl.org Director General: www.mpi-cbg.de/news-outreac...

Anthony Hyman to become next EMBL Director General

Founding Director of MPI-CBG will lead Europe's life sciences laboratory

mpi-cbg.de

EMBL@embl.org · 8mo ago

Anthony A. Hyman will become EMBL’s next Director General. He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999. www.embl.org/news/people-...

Exceptional work by Enya (TU Delft) and Laurell (Frankfurt) 💪 and a great team 👍 & great support by our Exc Cluster @scale-cluster-ffm.bsky.social @goetheuni.bsky.social & we thank our Editor and the Reviewers for their valuable input @natcomms.nature.com #FluorescenceFriday #smartmicroscopy #RNA

We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social 🙏 (1/3) www.nature.com/articles/s41...

🚨🔬A great opportunity to work with high-end microscopy in an exciting scientific environment. Please re-post 🙏 @goetheuni.bsky.social @scale-cluster-ffm.bsky.social 👇🏻

Yvonne Stahl@yvonnestahl.bsky.social · 9mo ago

A great opportunity to join our newly established imaging centre in Frankfurt as engineer/technician. If you love light microscopy, please apply! Please share!

A great opportunity to join our newly established imaging centre in Frankfurt as engineer/technician. If you love light microscopy, please apply! Please share!

www.biorxiv.org/content/10.1...

Nuclear-import receptors remodel the dilute phase to suppress phase transitions of RNA-binding proteins with prion-like domains.

RNA-binding proteins (RBPs) with prion-like domains, including FUS, hnRNPA1, and hnRNPA2, assemble into functional, metastable condensates that organize ribostasis, but can also transition into self-t...

biorxiv.org

💥"RMU-EXCITE": Die Allianz der Rhein-Main-Universitäten (RMU) @goetheuni.bsky.social, @unimainz.bsky.social und @tuda.bsky.social hat ihren gemeinsamen Antrag als #Exzellenzverbund (Förderlinie Exzellenzuniversitäten) eingereicht! Pressemitteilung: www.rhein-main-universitaeten.de/news/rhein-m...